Module D - CNR, ELETTRA, ESRF, ILL, ISIS: the Access Procedure and Organization Matters

CNR, ELETTRA, ESRF, ILL, ISIS: the Access Procedure and Organization Matters

European Synchrotron Radiation Facility

Access to the ESRF for the International Scientific Community

[& industry]

Categories of Proposals and Users

Public peer-reviewed Proposals

(free of charge, must publish results)

Collaborating Research

Group (CRG) Proposals

CRG Office

User Office

BDU Office

Proprietary Research Proposals



Access 4 calls per year March 1st - Aug 31th ESRF users May 1st – Nov 1st Italian users

Contact: Francesco d'Acapito [email protected]

http://www.esrf.eu/UsersAndScience/Experiments/CRG/BM08/

The Italian CRG: GILDA beamline @ ESRF

l  Italian funded project: priority to national researchers l  X-ray absorption and diffraction

l  Energy range 6-90 keV






CRG Office

User Office

BDO Office


ESRF Finance Service, 20 December 2012 : ESRF Access – Joanne McCarthy

ESRF User Community The ESRF public research programme covers 11 scientific areas : Ø  Chemistry-related Studies Ø  Electronic & Magnetic Properties Ø  Crystals & Ordered Systems, Structures Ø  Disordered Systems & Liquids Ø  Applied Materials & Engineering Ø  Environment & Cultural Heritage Matters Ø  Macromolecular Crystallography Ø  Medicine Ø  Methods & Instrumentation Ø  Soft Condensed Matter & Biological Materials Ø  Surfaces & Interfaces

PROPOSAL REVIEW STRUCTURE

CH - Chemistry

ES - Earth Sciences

EV - Environment

HC - Hard Condensed Matter Proposals are numbered

HG - Cultural Heritage using these 2-letter codes

LS - Life Sciences e.g. CH-123, MA-1032

MA - Applied Materials

MD - Medicine

ME - Engineering

MI - Methods and Instrumentation

MX - Structural Biology

SC - Soft Condensed Matter

Chemistry11% [10% ]

Elec t. & Magn. Properties

15% [14% ]

Crystals & Ordered Structures

10% [10% ]

Disordered Systems4% [5% ]

Applied Ma terials, Enginee ring11% [10% ]

Environment & Culture7% [7% ]

Ma cromolecula r C rystallography

13% [14% ]

Medicine4% [4% ]

Meth & Instrum3% [2% ]

Soft C ond. Ma tter10% [9%] )

Surfa ces & Interface s9% [11%]

O ther: Tra ining, fea sibility tests,

proprie tary research4% [4%]

Shifts delivered for Experiments, 2010: total 15 214

Percenta ges for 2009

in pa re ntheses.

Public Interest in the ESRF

1892 1907 20132047 2035 2035

1905

828 888 903 929 974

778 719

1510 1539 15591731

1559

1344

0

200

400

600

800

1000

1200

1400

1600

1800

2000

2200

2400

2006 2007 2008 2009 2010 2011 2012

Year s

Proposa ls submitted and al located beamtime, 2006 -2012

Pro posals submittedPro posals allocated b eamtime

Ex perimental Sess ions

REVIEWED PROPOSALS STANDARD Research Proposals LONG TERM PROJECT Proposals Structural Biology BAG Proposals Structural Biology Rolling Proposals

Applying for Public Beamtime

Each proposal will have a Main Proposer and co-proposers Main Proposer is the unique contact point for the ESRF

- complete and submit the proposal - receives all correspondence - registers all users for the experiment

Standard ESRF Proposals •  Proposals for beamtime are submitted electronically, via the Web, for two deadlines each year:

1st March - for beamtime between August and February the following year; 1st September - for beamtime between March and July.

•  For the most part, proposers submit a single request for each separate set of measurements they wish to carry out. This standard proposal is valid for 6 months. •  Proposers select a

Ø  Scientific Category and Beamline(s) •  Proposal consists of

Ø  Electronic form (proposers, beamline, beam/equipment requirements, sample data...) Ø  Experimental Methods Template (2 page free text pdf document with fixed sub-sections)


Long Term Project (LTP) Proposals •  1- to 3-year beamtime allocation for projects requiring heavier investment of resources over long time period.

•  One annual deadline for LTP submission on 15th January (evaluation in April BTAP).

•  The Main Proposer should be affiliated to a scientific institution of an ESRF Member or Associate country

•  Criteria for acceptance : Ø  scientific excellence

Ø  commitment of contribution of financial, technical and/or human resources during the implementation of the LTP

Ø  identifiable benefit to the ESRF User community (e.g. new technique, new instrument, new possibilities for the beamline)

Ø  public beam time availability on the beamline requested.


Structural Biology Beamlines (MX and Bio-SAXS)

BAG Proposals Ø  Proposers within (mainly) geographic areas have been grouped into Block Allocation Groups (BAGs).

Ø  BAG status awarded for 2 years and applications submitted once per year.

Ø  Beamtime is awarded automatically for the interim 6 months.

Ø  The BAG must report on its activities

Ø  after the first year with a Progress Report

Ø  after the second year with a Full 2 Year Report

Ø  both are Web-based

Ø  Beamtime distributed across suite of 7 ESRF and 3 CRG beamlines.

Ø The allocated beamtime is managed by the BAG Responsible.

Ø  Currently 49 of these Block Allocation Groups in operation (>300 laboratories).


Structural Biology Beamlines (MX and Bio-SAXS)

Rolling Proposals Ø  Crystals obtained = beamtime required within weeks !!

Ø  For non-BAG scientists or groups - designed to ensure rapid access to ESRF MX beamlines and encourage use by smaller groups

Ø  Proposals may be made at ANY time – no deadline

Ø  Proposals reviewed electronically by Beam Time Allocation Panel within 2-3 weeks of reception at ESRF

Ø  Beam-time scheduled within 6-8 weeks if application is successful


Proposal Submission

Technical Feasibility by BL Resp. Grading by Review Cttee members

Review Committee Meetings

Per BL, rank all proposals in order of grade. Done by ASFRI program with flexibility of bottom 20%

Juste Retour and Pro Rata Calculations

DoR Approval / Changes

Recommendations to BL scientists / Changes

Accepted Proposals to BL Scientists

Decision (shifts & comments) to Proposers

Assessment by Safety Group

Proposal Review Process

Proposal Review Three kinds of review take place:

Ø  Scientific Peer Review - made by Review Committees representing each of the 11 scientific areas - 8 appropriate specialists appointed by ESRF Management - the Scientific Advisory Committee has a representative in each Committee - meet in Grenoble in April and October each year to discuss and rank proposals

Ø  Technical feasibility (TF) assessments - made by the Scientist in charge of each beamline - advice on number of shifts required for each experiment

Ø  Check for compatibility with Safety requirements - made by Experimental Safety Officers (sample, equipment required…) - sample safety sheets for biological samples, proposal forms for others

Safety and TF assessments made in parallel with scientific review, details available for Review Committee meetings


Finalising Decisions ESRF Management finalises decisions based on

Ø  Recommendations from the Review Committees

Ø  Final technical feasibility checks by the Beamline Scientists

Ø  Fine tuning for return on contributions by ESRF participating member countries - projects for experiments originating in countries which are not members of the ESRF are accepted provided they are highly ranked by the Review Committees

The User Office then informs the applicants of the decisions.


Kurchatov Institute, 14 July 2011 : ESRF Access – Joanne McCarthy

Scheduling Experiments

Ø  Template of beam modes drawn up by User Office (Machine, Safety and Beamline Scientists) – used by scientists for scheduling

Ø  Beamline Scientist receives lists of accepted experiments from User Office

Ø Assigns a local contact scientist to each experiment

Ø Contacts successful groups to draw up beamline schedule

Ø Completes and submits electronic schedule

Ø User Office issues invitations for experiments

Once the beamline schedule has been finalised, the User Office sends an Invitation email to the proposers. Main Proposers registers all users for the experiment by completing the “A Form”. Each user registered must

Ø  have completed the Safety Training (valid one year) Ø  complete and validate a User & Safety Declaration form (valid for specific experiment only)

Experiment Registration

A Form

Site Entrance Request

Storage ring access rights

Canteen card

Guesthouse / hotel

Reimburse-ment

Safety Approval

Form

Samples & Environmen

t

User Support Travel & Subsistence ESRF contributes to the expenses of 3 academic scientists (4 for LTPs and BAGs) affiliated with laboratories in contributing party countries, per experiment. Travel arrangements may be requested and pre-paid through the ESRF Travel Office Reimbursement of travel expenses will be made on the basis of the second class train fare, or the appropriate PEX air fare. Preference must be shown for the most economical means of transport.

Guesthouse Guesthouse on site (opened in 1995) for visitors, primarily Users. Number of ESRF Beds: 153 (The new wing is shared with ILL, which has 40 beds). Cost per night to ESRF: 12.76 €, breakfast included (31.81 € for non-reimbursed Users) Canteen A canteen, also constructed on site, serves meals during the day, and at night and weekends when the ESRF machine is in operation. Typical cost of a meal for Users ~7-8€.

At the ESRF….

Reports & Publications

Use of PUBLIC ESRF beamtime = OBLIGATION to PUBLISH and REPORT on beamtime used

Reporting

Ø  Users allocated beamtime are requested to provide a 2-page Experimental Report after each experiment

Ø  forwarded to Review Committees who monitor effective use of beamtime.

Ø  required as support for new requests for beam-time

After the Experiment

Ø  There is also a Web-based User Evaluation Questionnaire to evaluate the success of their experiment, any failures and reasons for failures, the quality of beamline components, and support from the beamline and administrative staff.

Publications Ø  Users are required to PUBLISH all successful results obtained from the use of ESRF public beamtime

Ø  Users must give proper credit to ESRF staff members and proper mention to ESRF facilities, the beamline in particular, which were essential for the results described in any ensuing publication

After the Experiment

Ø  Proposal review committee members pay special attention to publication record….groups not publishing are unlikely to be given further beamtime

Ø  Users are required to inform ESRF of publications resulting from measurements made at ESRF by deposition in the ILL/ESRF Library database

Ø  may be entered or consulted via the online ILL/ESRF Library database

Ø  may be entered using a simple Web form (reminder email every 6 months)

Ø  may only be cited on new proposals for beam-time if they exist in the library database

The ESRF User Portal / SMIS Tools What is the ESRF User Portal?

The ESRF User Portal gives direct access to all administrative tools for ESRF users from a unique Web site.

It also provides the majority of administrative tools required by inhouse staff for the management of proposals and experiments, and by committee members for proposal review.

All information is presented in a user friendly environment.

A User/Manager must register on the User Portal before having access to any tools, including proposal submission. After logging in with their own personal identification (user name/password), Users with particular responsibilities have privileged access to other tools according to their role.

For User : From proposal submission through experiment to deposition of experiment report For administrative staff : From proposal submission to User reimbursement






CRG Office

User Office

BDO Office


ESRF Finance Service, 20 December 2012 : ESRF Access – Joanne McCarthy

Some of our Partners

25 6 July 2010

Airbus landing gear: piston rod

•  TM HIGH-STRENGTH STEEL

•  8mm WALL THICKNESS

•  STRAIN MEASURED AT THE INNER SURFACE OF THE CYLINDER

26 6 July 2010

Airbus landing gear: piston rod

“The development of high performance catalysts requires catalyst design at the

atomic level”

3D imaging of complex materials: Grain of cement

28 Artioli et al., Int. J. Mat. Res. 2012.

High-throughput protein crystallography…

Sample mounter/dismounter

Information exchange

Access to BL Control PCs (NX Server/Client)

Control GUI

1.  Peer review access

§  Free beam time, but publish results 2.  Paid R&D services for industry

§  Confidential, all IP for the client §  Buy beam time or use mail-in services §  Contract R&D

3.  Funded staff for joint R&D programmes §  PhDs and post-docs

4. Expert partner in National and European projects 5. Training for industry

Connecting industry to our facilities

Collaborating with Industry

l  Example on catalysis R&D ü  SaintGobain funded 18 month post-doctoral position ü  Proprietary R&D for SaintGobain using the post-doc embedded full-time

at the ESRF and beam time provided by ESRF ü  Joint R&D programme for publishable work between SaintGobain and

ESRF ü  Post-doc trained in synchrotron techniques by ESRF experts

31

Example: Characterisation Programme for Micro- and Nano-Electronics IRT Nanoélec

31st Jan 2013 Genova, CNR Roadshow

The Biocrystal Bacility offers to the CNR scientific network access to production and interpretation of crystals of biological macromolecules. The aim is to increase the community of Italian users of European facilities and Initiatives such as the European Synchrothron Radiation Facility (ESRF). We pursue a collaboration with ESRF, also through joint training at the doctoral and post-doctoral level at the ESRF facilities. The Facility has been established at the Institute of Molecular Biology and Pathology of CNR, in collaboration with the Dept. of Biochemistry of the “Sapienza” University of Rome.

Crystallization

Structure solution and refinement

X-ray diffraction

www.biocrystafacility.it [email protected] CNR 90th Anniversary, ROADSHOW 2013

31st Jan 2013 Genova, CNR Roadshow

Protein structure analysis Crystallization

Structure solution and refinement

X-ray diffraction

At the Biocrystal Facility: •  Setting the biomedical or

biotechnological project: defining objectives and critical points.

•  Consulting in the production and purification of proteins.

•  Robot crystallization screening and optimization with in-house equipment and supporting application to European initiatives.

•  Synchrotron data collection. •  Assistance and training, for the

determination and analysis of the three-dimensional structure of proteins and their functional complexes.

www.biocrystafacility.it [email protected] CNR 90th Anniversary, ROADSHOW 2013

Thank You for your attention!

CNR-‐ISIS 2013 CNR 90th Anniversary, ROADSHOW 2013

Access Procedures to Neutrons (and Muons) at ISIS

CNR 90th Anniversary, ROADSHOW 2013

CNR-‐ISIS 2013

Big facilities for small science Harwell Science & Innovation Campus

Diamond – XRays

ISIS – Neutrons and Muons

Central LASER Facility

Research Complex

ISIS is a ‘super microscope’ to look at materials at the atomic scale

TS1 TS2


CNR-‐ISIS 2013

Hard

Soft multidisciplinary condensed matter science

1960

1970

1990

1980

Expanding the Frontiers

Berkeley 37-inch cyclotron

350 mCi Ra-Be source

Chadwick

1930 1970 1980 1990 2000 2010 2020

105

1010

1015

1020

1

ISIS

SNS

Sorgenti Pulsate

ZINP-P

ZINP-P/ KENS WNR

IPNS

ILL

X-10

CP-2

Reattori

HFBR

HFIR NRU MTR NRX

CP-1

1940 1950 1960

Effe

ctiv

e th

erm

al n

eutr

on fl

ux n

/cm

2 -s

(Updated from Neutron Scattering, K. Skold and D. L. Price, eds., Academic Press, 1986)

CNR-‐ISIS 2013

Rutherford Appleton Laboratory

!   A"racts ~1200 users per year !   Delivers over 700 different

experiments every year. !   ~400 publica?ons per year.

!   Interdisciplinary Research Centre

!   Physics !   Chemistry !   Materials science !   Earth sciences !   Engineering !   Pharmaceu?cal science !   Biomolecular science !   Cultural heritage


How to apply for ISIS beamMme

•  Two calls for proposals each year – deadlines are 16 April and 16 October

•  Use the ISIS online proposal system (see ISIS website)

•  Requires a 2-‐page self-‐contained science case

•  Proposals are peer-‐reviewed by science experts at the ISIS Facility Access Panel mee?ngs in June and December

•  Successful proposals are then scheduled – normally a few months aUer the panel mee?ngs



•  PROPOSAL ROUNDS -‐ biannual

•  RAPID ACCESS – for urgent studies. Submit a proposal any ?me – rapid peer review

•  EXPRESS ACCESS – for small amounts of beam?me (to test a sample, for a RT crystal structure, etc) – available on some beamlines – submit a proposal any ?me – experiment run when possible, user does not need to come

•  INDUSTRIAL ACCESS – through our collabora?ve R&D scheme (or industry can pay directly for access)


Industrial CollaboraMve R&D Scheme

FY Days Allocated Companies

11/12 53 9 12/13 48 (to date) 7

FY11/12 FY11/12

• Started 2011; lower risk route for industry • Provides a lower-‐risk way in for industry • Industry can decide aUer the experiment if results should remain confiden?al (in which case they pay commercial rate) • Scheme ensures ISIS is informed of benefits to industrial partner


working with ISIS….

Industrial CollaboraMve R&D Scheme


•  Talk to ISIS scien?sts before submi`ng a proposal

•  All ISIS experiments are assigned a ‘local contact’ – in-‐house ISIS scien?st who is expert on the instrument

•  You don’t need to have used neutrons or muons before to use ISIS!


ISIS User Office helps with prac?cali?es of visits such as accommoda?on.


ISIS Academic User Base

Year R’nds Visits Unique Visitors

No. Applicants

2006 2 1405 873 2007 1 937 611 2008 2 2185 1112 2455 2009 2 2002 1000 2490 2010 1 1519 801 2523 2011 2 2300 1174 2709

Visits Academic Student Total UK 949 741 1690 Int. Partner 189 60 249 Int. (Other) 249 112 361 Total 1387 913 2300

Unique Vis’trs Academic Student Total UK 350 341 691 Int. Partner 176 52 228 Int. (Other) 174 81 255 Total 700 474 1174

• Over 2000 user visits per year, by over 1000 individual researchers


ISIS – PublicaMons

• High impact journals: list defined by ILL Europhysics Journal E, Europhysics Le"s., Chemistry of Materials, JACS, Langmuir, Macromolecules, Nature family, Phys Rev family, Science

Year No. pubs. reported to

date

No. in high impact journals

2009 417 118 (28%) 2010 394 134 (34%) 2011 406 131 (32%)


Use of IS

IS

Italian figures at March 2012: v Typically ~700 experiments are carried out at ISIS each year; v up to 2000 user visits per year, 400 – 500 publications per year; v Use of 25 + 1 neutron instruments (includes INES) + 3 muon spectrometers Apart from INES, all other instruments are completely in the public domain, no CRGs


15


Italy 3.5%


�  France, Germany, UK (1973) �  Scientific Partners

-  Spain 1987 -  Switzerland 1988 -  Austria 1990 -  Russia 1996 -  Italy 1997 -  Czech Rep 1999 -  Sweden,Hungary 2005 -  Belgium, Poland 2006 -  Slovakia, Denm’k 2009 -  India 2011

�  Now cover 96% of EU

Budget ILL: 82 M€ ( 2009 )

Associates69%

Scientific members

24%

Carry forward

3%

Own income

4%

Italy 3.5%


�  500 staff (3% Italian) �  4500 users �  1400 Proposals* �  2000 User visits* �  800 Experiments* �  200 reactor days* �  27 (+10) instruments (+CRGs) �  600 Refereed papers*

* In 2011

French 64%

German10%

British11%

Other member countries

5%

Italiani3%

Others5%

ILL staff


�  500 staff �  4500 users (It 300, 130 labs) �  1400 Proposals* �  2000 User visits* �  800 Experiments* �  200 reactor days* (It 5-6 %) �  27 (+10) instruments (+CRGs) �  600 Refereed papers*

* In 2011


�  500 staff �  4500 users (It 300, 130 labs) �  1400 Proposals* �  2000 User visits* �  800 Experiments* �  200 reactor days* (It 5-6 %) �  27 (+10) instruments (+CRGs) �  600 Refereed papers*

* In 2011


Use of IL

L


% Requested % Allocated

�  500 staff �  4500 users �  1400 Proposals* �  2000 User visits* �  800 Experiments* �  200 reactor days* �  27 (+10) instruments (+CRGs – 2 Italian) �  600 Refereed papers*

* In 2011


�  Crucial region of slowish dynamics mainly applied to biological macromolecules but also polymers, glasses and superconductors

�  CRGA shared 50:50 with ILL; co-funding CNR and UJF (France) -  e.g. measurements of protein dynamics to study the relationship stiffness ,

temperature and biological function -  Protect myoglobin against drought with a trehalose sheath, preventing

denaturation through increased rigidity

Zaccai and Cordone CNR 90th Anniversary, ROADSHOW 2013

�  Unique probe of a low-Q (large amplitude) dynamics over a wide energy range (≈1-100 meV)


�  Low-energy dynamics in disordered materials (liquids, glasses and metals) �  Study of aqueous solutions – particularly in biology (enzymes, membranes) �  Transport properties of artificial polymers, membranes, nanostructures �  Magnetic materials: separate phonons and magnons as Q → 0

Orecchini et al – collective dynamics of water molecules in the hydration shell of the enzyme responsible for breaking the RNA CNR 90th Anniversary, ROADSHOW 2013

�  500 staff �  4500 users �  1400 Proposals* �  2000 User visits* �  800 Experiments* �  200 reactor days* �  27 (+10) instruments �  600 Refereed papers*

* In 2011

Energy (8%) Environment (3%)

Computer and Information Technology

(8%) Materials and

nanotechnology (29%)

Health (18%)

Fundamental Science (35%)


Publications Policy Acknowledgement in any publication should award the support received by CNR. Examples for ILL and ISIS are the following: v  This work was supported within the CNR-ILL Agreement

795.1 concerning collaboration in scientific research at the ILL. The financial support of the Consiglio Nazionale delle Ricerche in this research is hereby acknowledged.

v  This work was supported within the CNR-STFC Agreement no. 06-20018 concerning collaboration in scientific research at the spallation neutron source ISIS. The financial support of the Consiglio Nazionale delle Ricerche in this research is hereby acknowledged

Access to neutron facilities


CNR 90th Anniversary, ROADSHOW 2013 www.ill.eu/news-events/press-room/ill-in-the-media/

NEUTRONS FOR SCIENCE…NEUTRONS FOR SOCIETY

Courtesy by Sean Langridge, ISIS

First beam from Nimrod

Congratulations from Cockcroft and

Chadwick

CNR-‐ISIS 2013

31

PRISMA project 1985-1987 built by CNR-ISM Institute (Frascati, Rome)

PRISMA, first instrument built within the first CNR-SERC (Science and Engineering Research Council) Agreement concerning collaboration in the exploitation and development of ISIS, originally signed in 1985.

When all started

A B

rief Story


CNR-‐ISIS 2013

When and Where the Neutron Story for CNR started from

32

Luigi Rossi Bernardi, CNR President, inaugurates PRISMA Instrument at ISIS, November 4th , 1988.

A B

rief Story


CNR-‐ISIS 2013

Neutron and muons: let us help you to view the materials

world in a unique way

www.isis.s\c.ac.uk

www.ill.eu


CNR-‐ISIS 2013

CNR, ESRF, ILL, ISIS: Training

v Neutrons & Synchrotron Radiation for Science, http://hercules-school.eu

HERCULES School

v Neutron Training Course, 5th – 14th March 2013 http://www.isis.stfc.ac.uk/learning/neutron-training-course/

Neutron Schools

v Le Giornate Didattiche, 22 June - 2 July 2013 http://sisn.it

v School of Neutron Scattering Francesco Paolo Ricci, spring-summer 2014, www.sonsfpricci.org,

v Oxford School on Neutron Scattering, 2 - 13 Sept. 2013, http://www.oxfordneutronschool.org

v International Neutron Scattering Instrumentation School (INSIS) http://neutrons.ornl.gov/conf/insis2012/