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Human coronaviruses (CoVs)
•severe acute respiratory syndrome (SARS)-CoV
•SARS-CoV originated from horseshoe bats, but palm civets acted as intermediate host allowing animal-to-human transmission
•Current knowledge indicates that human CoVs emerged from animal ancestors and that various animal CoVs also crossed the species barrier
The high frequency of genetic recombination and mutation make CoVs well capable of adapting to new hosts
I’m stanger!
Number of MERS-CoV cases by country and year
• Between 2012 and 7 July 2015, 1368 laboratory-confirmed cases of human infection with Middle East respiratory syndrome coronavirus have been reported to WHO, including at least 487 deaths
• Overall, 65% of cases where gender has been reported are male and the median age is 50 years
What’s MERS Virus?
• Middle East respiratory syndrome coronavirus (MERS-CoV)
• Genome: (+)ssRNA, ~30kb (20-33kb) •Virion: Enveloped, roughly spherical, 120-160nm, large club like protrusion (spike protein)
Common Symptoms Fever
Fever with chillsFever with rigors Cough
Shortness of breath
Myalgia Fever
Shortness of breathFever with chills
Fever with rigors
Cough
MyalgiaFever
Shortness of breath
Fever with chillsFever with rigors CoughMyalgia
2-14 days
Kidney failure
Pericarditis Dessiminated intiavascular coagulation2-14 days
Kidney failurePericarditisDessiminated intiavascular coagulation
http://www.straitstimes.com/singapore/south-koreas-mers-outbreak-10-things-to-know-about-the-virus