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247 patients from 2004 to 2012 Prostate cancer Brachytherapy low-dose Nucletron 125I seeds Spot Pro SPC, SeedSelectron delivery system SPSS statistical analysis
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Learning curve impact from 8 years of experience in low-dose
brachytherapy for prostate cancer
Servicio de Radiofísica y PRInstituto Oncológico
Juan-Senabre XJ, Pérez M, Sánchez AL, López-Tarjuelo J, Santos-Serra A, Conde AJ, Beltran J, Ferrer C.
Purpose
Purpose
Dr. Mateo Pérez, urologist
I believe is feasible to analyzechart data patients to find out
learning curve results
Go ahead
What’s the learning curve?
Tm = T1 m(log2 L)
T1: time 1st PPBTm: time mth PPBL = learning rate
Go ahead
Is it applicable for this study?
PP
B t
ime
exec
uti
on
#PPB
D90
, V10
0
#PPB
Patients & methodsKruskall-Wallis test
144 Gy PD
(100, 108) Gy PD
Patients & methods
• Toshiba, Hitachi TRUS acquisition• Track-stepper software control• SPOT Pro TPS (Nucletron/Elekta)• 125-I Nucletron seeds (Isotron)• SeedSelectron automatic delivery system• #Med. Phys.: 4• #Rad. Oncol.: 3• #Urol.: 2
Interobserver dispersion?
Results. Time procedure
Results. Time procedure
n = 220, 11% rejectedL = 85.7% learning rate
Results. Nomogram
Results. DVH
Conclusions
Significant statistical results:• Time procedure• D90, V100• RV100
Consistent results:• Nomogram• #seeds, #needles• CN, DHI