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The Importance of Method: Lots of Phylogenetic
Signal, Lots of ProblemsLiliana M. Dávalos, Paúl M. Velazco, Eliécer E. Gutiérrez
0.8 unitsknowlesi
vivax
falciparumreichenowi
gallinaceumbergheichabaudiyoelii
Base composition provides signalDávalos & Perkins 2008 Genomics
• NJ log-det distances• Bayesian mixture or cat• ML model by site• ML recode 3rd pos to RY• ML recode RY to binary
• ML codon model• ML protein model
Phylogenetic methods
Dávalos, Cirranello et al. 2012 Biol Rev
Which method performs best?
monophyly ~ αclade + βphylogenetic method
phylogenetic method is observed across clades (i.e., each clade has 8 observations of monophyly)
Which clade characteristics affect inference?
αclade ~ μall clades + βvariable+ εclade + ∑
variable is observed by clade (i.e., clade size, base composition heterogeneity, saturation)
Yohe et al. 2015 Biol Lett
• Don’t ignore heterogeneous base composition• Always test before
inferring• Even within
families• Not all methods
equal, choose appropriately
Conclusions
Photo by B. Patterson