www.guidetopharmacology.org

GtoPdb and GtoImmuPdb in the context of

other informatics resources

Chris Southan

NC-IUPHAR and BPS Focused Meeting on the Guide to IMMUNOPHARMACOLOGY, 9-10

April 2016, Edinburgh

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http://www.slideshare.net/cdsouthan/gtopdb-and-gtoimmpdb-in-context

GtoImmuPdb has no direct overlap

• ImmPort focused on the collation of data sets

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ImmunoDB

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• also primarily for data input

Immune Epitope Database 2.0

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Collaborative

opportunities

immgen.org

5

• Currently mouse but will expand to human

The GtoPdb ecosystem is crowded

6

http://www.guidetopharmacology.org/helpPage.jsp#databaseLinks

Direct overlaps (I)

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Direct overlaps (II)

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Overlapping content by protein targets

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Overlapping content by chemistry

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• 1259 GtoPdb CIDs are not in the other three

• We all concur on 1036

Integrated bioactivity databases: also getting crowded

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http://cdsouthan.blogspot.co.uk/2015/11/integrated-bioactivity-databases.html

Integrated databases: specificity issues

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Important sub-ecosystem

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Subset overlaps (I)

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Subset overlaps (II)

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Discussion points

• Maximising GtoImmuPdb expansion

• Sustaining GtoPdb expansion

• Adding/enhancing unique content/quality/divergence

• Advertising/highlighting unique value

• Collaborative opportunities

• Dealing with errors in other resources

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