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Review the importance of the strongly growing epigenetic market
Discuss the latest epigenetic breakthroughs in your field of epigenetic studies
Explore new avenues to network and showcase your epigenetic research work and discoveries
Discuss the use of Biomarkers as a tool for achieving optimal detection
Network with your academic and industry colleagues to brainstorm on latest epigenetic application
Review the latest epigenetic tools and technologies available in the market to aid your research
Why Attend?
2nd Annual Epigenetics Discovery Congress Novel Inhibitors & Emerging Targets for Drug Discovery
8th - 9th September 2016, London, UK
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Epigenetics has flourished to become one of the most revolutionary areas of science over the past decade. Also, advances in the understanding of epigenetic processes, have led to a burst in interest in this area as a potential source of new targets for the discovery of medicines.
While the promise of epigenetics is significant, it also presents some interesting challenges like pathways and mechanisms underlying epigenetics, using right screening platforms, bottlenecks in translational and clinical phase, collating epigenetics data with proper analysis and finding the right biomarkers.
At the 2nd Annual Epigenetics Discovery Congress, which will be held on 8-9 September 2016 in London, UK aims to provide a platform for researchers, academics and industry professionals working in epigenetic research to avail an opportunity & explore the potential of epigenetics to contribute towards novel and existing therapeutics, current progress and trends in the inclusion of epigenetics in drug discovery and development.
Along with the advancements in technologies and solutions, the conference will also focus on highlighting some of the emerging trends in terms of drug discovery with respect to evolving targets, inhibitors, biomarkers and clinical success of epigenetics across various diseases.
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Tony at [email protected]
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Gold Sponsors:
Silver Sponsors:
Sponsor/Exhibitors:
Supporting Association:
THE EPIGENETICS SOCIETY
Media Partners:
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Speakers:
Advisory Panel:
Dr. Tamara Maes Chief Scientific Officer, Oryzon, Spain
Dr. Paola B. Arimondo Research Director, CNRS EtaC, France
Dr. Hajji Nabil Lecturer in epigenetics and translational oncology, Imperial College London, UK
Prof. A. GanesanProfessor of Chemical Biology University of East Anglia, Norwich, UK
Dr. Brian LohseAssociate Professor, EpiDiscoverY, Faculty of Health and Medical Sciences, Department of Drug Design and Pharmacology, University of Copenhagen, Denmark
Jenny SouthgateProfessor of Molecular Carcinogenesis Director, Jack Birch Unit, Department of Biology,University of York, UK
Prof. Dr. Gianluca SbardellaAssociate Professor of Medicinal Chemistry, Head of EpigeneticMedChemLabUniversità di Salerno, Italy
Dr. Matthew Suderman Senior Research Associate in Epigenetics and Social ScienceUniversity of Bristol, UK
Prof. Guro Elisabeth LindGroup leader Epigenetics, Department of Molecular Oncology, Institute for cancer research, Oslo University Hospital, Norway
Dr. Manfred KoeglDirector Oncology ResearchBoehringer Ingelheim, Vienna, Austria
Dr. Tobias A. KnochGroup Leader Biophysical Genomics, Cell Biology & GeneticsErasmus MC, Rotterdam, The Netherlands
Dr. Gian Gaetano TartagliaGroup Leader, Gene Function & Evolution, Centre for Genomic Regulation (CRG), Barcelona, Spain
Prof. Irene Maeve Rea MD, BSc (Hons), FRCP, FRCP(Ed), FHEA | Professor Emeritus School of Medicine, Dentistry and Biomedical Science Queens University Belfast | Visiting Professor, NI Centre for Translational Research, Ulster University
Prof. Dr. F.J. (Frank) DekkerAssociate professor, Medicinal Chemistry, University of Groningen, Netherlands
Prof. Stephen J ShuttleworthChief Scientific Officer Karus Therapeutics Ltd, England
Dr. Richard ChesworthSenior Vice President Molecular DiscoveryEpizyme, USA
Prof. Richard MeehanProgramme Leader, Chromosomes and Gene Expression MRC Human Genetics Unit MRC IGMM, University of Edinburgh, UK
Prof. Rosalind M JohnDivision Leader for Pathophysiology and RepairCardiff School of Biosciences, UK
Prof. Dr. Reinhard StögerAssociate Professor in EpigeneticsUniversity of Nottingham, England
Dr. Moshe SzyfGlaxo Smith Kline and James McGill Professor, Department of Pharmacology and Therapeutics, McGill University Medical School, Canada
Prof. Dr. Manon van EngelandDept. of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Netherlands
Dr. Paola B. ArimondoResearch DirectorCNRS EtaC, France
Dr. Tamara MaesChief Scientific Officer Oryzon, Spain
Dr. Daniel VittCSO4SC AG, Germany
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Conference Day One, Thursday, 8th September 201608:00 Registration and Refreshments
08:50 MnM Conferences’ Welcome Address
08:55 Opening remarks by the Chair
Developmental Biology and Environment
09:00 Keynote address: Epigenetic regulation of the tumour micro environment (TME) - immuno oncology meets epigenetics• 4SC-202 is a new clinical stage epigenetic regulator of the TME • Enhanced T-cell infiltration in tumours may offer a unique clinical boost of responses to checkpoint inhibitors • Further approaches of epigenetic immune regulation - beyond HDAC inhibitors Dr. Daniel Vitt, Vorstand, CSO, 4SC AG, Germany
09:25 Epigenetic profiling and environmental challenge• 5mC/5hmC profiling tracks environmental exposure in model systems• Allows identification of potential epigenetic predictors of end point pathologies• Studying the effects of environmental triggers on the epigenome will enable identification of novel biomarkersProf. Richard Meehan, Programme Leader, Chromosomes and Gene Expression, MRC Human Genetics Unit MRC IGMM, University of Edinburgh, UK
09:50 Stability and flux of DNA methylation patterns• Genomic programs regulating energy balance evolved to be buffered or ‘canalised’ against genetic variation• Large genetic regulatory networks can acquire novel epigenetic states in response to environmental challenges• A new metric to quantify and compare epigenetic flexibility and stability across loci, cell types, and developmental stagesProf. Dr. Reinhard Stöger, Associate Professor in Epigenetics, University of Nottingham, England
10:15 Presentation by NuGEN
10:45 Morning Refreshments | Networking | Poster presentation | One to One meetings
11:30 Environmental programming of maternal care and offspring behaviour by an epigenetic mechanism• Prenatal environment and the developing placental epigenome• Placental function and fetal growth• Dual programming of maternal care and offspring behaviour Prof. Rosalind M John, Division Leader for Pathophysiology and Repair, Cardiff School of Biosciences, UK
Translational Epigenetics11:55 Epigenetic regulation of epithelial homeostasis: an emerging story of health and disease
• Urothelium is a transitional epithelium that functions as a self-repairing, urinary barrier within the bladder and associated urinary tract. • I will present experimental evidence that at the cellular level, the homeostasis of human urothelium is regulated epigenetically • I will further consider how local and environmental factors effecting epigenetic deregulation can create an imbalance in tissue
homeostasis, with chronic ulceration versus cancer at the extremes of chronic bladder diseaseProf. Jenny Southgate, Professor of Molecular Carcinogenesis, Director, Jack Birch Unit, Department of Biology, University of York, England
12:20 Presentation by Cell Signalling
12:50 Lunch | Networking | Poster presentation | One to One Meetings
13:50 Presentation by Roche/Kapa Biosystems Ltd.
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Clinical Epigenetics and Biomarkers
14:15 Findings in DNA methylation measured across the life-course in a large well-characterized human cohort• Prenatal biomarkers that remain and disappear• Static and changing biomarkers of phenotype• Genetic influences and causal applicationsDr. Matthew Suderman, Senior Research Associate in Epigenetics and Social Science, University of Bristol, UK
14:40 DNA methylation biomarkers for early and non-invasive detection and monitoring of bladder cancer • Using methylome sequencing (RRBS) to identify high performing DNA methylation biomarkers specific for bladder cancer• Leveraging biomarkers to reduce the economic costs of bladder cancerProf. Guro Elisabeth Lind, Group leader Epigenetics, Department of Molecular Oncology, Institute for cancer research, Oslo University hospital, Norway
15:05 Genetics or Lifestyle: Is Epigenetics the Missing link in the Longevity Phenotype? • Human longevity is a complex trait and increasingly we recognise that both genes and lifestyle interact in the longevity
phenotype.• Family clusters of nonagenarian and centenarian siblings, who show both exceptional age-span and health-span are likely to
have inherited facilitatory gene groups but also have nine decades of life experiences and behaviours which have interacted with their genetic profiles.
• Although much remains to be discovered, this lecture will discuss some of the epigenetic and environmental factors which appear important in good quality longevity and link known epigenetic mechanisms to themes identified by nonagenarians themselves related to their longevity.
Prof. Irene Maeve Rea, Emeritus Professor School of Medicine, Dentistry and Biomedical Science, Ulster University, Ireland
15:30 Afternoon Refreshments | Poster Presentation | Networking | One to One Meetings
16:15 Solution Provider Presentation; contact [email protected]
16:45 DNA methylation markers for management of cancer: pitfalls and perspectives• Discovery of DNA methylation markers• Implementation of methylation markers into clinical practice• Pitfalls and perspectivesProf. Dr. Manon van Engeland, Dept. of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Netherlands
17:10 Decoding the 3D Multi-Loop Aggregate/Rosette Chromatin Architecture, Dynamics, and Functional Epigenetics of Genomes• Novel combination of chromosome interaction capture (T2C) and fluorescence correlation spectroscopy (FCS)• Final architecture and dynamics of genome organization• The tight entanglement of sequence, structure, and functional epigenetics Dr. Tobias A. Knoch, Group Leader Biophysical Genomics, Cell Biology & Genetics, Erasmus MC, Rotterdam, The Netherlands
17:35 Closing Remarks by the Chair
17:45 Networking and Drinks Reception
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Conference Day Two, Friday, 9th September 201608:15 Registration and Refreshments
08:50 MnM Conferences’ Welcome Address
08:55 Opening remarks by the Chair
09:00 Keynote: Drug Discovery and HMTs• Overview of Histone Methyl transferases• Drug discovery of HMTs• Clinical Data of HMTs so farDr. Richard Chesworth, Senior Vice President Research, Epizyme, USA
Epigenetics Inhibitors and Emerging Targets
09:25 KATching lysine acetylations in inflammation• Role of lysine acetylation in inflammation• Development of histone acetyltransferase inhibitors• Selective HDAC inhibitors in inflammationProf. Dr. Frank Dekker, Associate professor, Medicinal Chemistry, University of Groningen, Netherlands
09:50 Targeting DNA methylation in cancer cells with non-nucleoside inhibitors• We have designed novel non-nucleoside inhibitors of DNA methyltransferases able to demethylate and reactive tumor
suppressor genes. • We applied three chemical strategies: High-Throughput Screening of chemical libraries, rational drug design based on
molecular modeling and the pharmacomodulation of known inhibitors. • The cellular consequences of this DNA demethylation are studied in comparison to nucleoside inhibitor decitabine.Dr. Paola B. Arimondo, CNRS, ETaC, France
10:15 Panel discussion Fostering the culture of collaborations between industry and academic researchers to deliver innovation, translation and impact of epigenetics on a global scale
• Nurturing translational research• Initiating drug discovery projects in collaboration with industry• Improving clinical development- Dr. Moshe Szyf, Glaxo Smith Kline and James McGill Professor, Department of Pharmacology and Therapeutics, McGill University Medical School, Canada
- Prof. Jenny Southgate, Professor of Molecular Carcinogenesis, Director, Jack Birch Unit, Department of Biology, University of York, England
-Dr. Richard Chesworth, Senior Vice President Research, Epizyme, USA
10:45 Morning Refreshments – Networking – Poster presentation and One to One meetings
11:30 Solution Provider Presentation; Please contact Steve Hambrook at [email protected]
12:00 Strategies to identify new inhibitor scaffolds for Histone Demethylases and Methylases• Strategies to discover new scaffolds: small molecules and peptides• DNA encoded peptide libraries• Fluorescence Assay development and testing on epigenetic targetsDr. Brian Lohse, Associate Professor, EpiDiscoverY, Faculty of Health and Medical Sciences, Department of Drug Design and Pharmacology, University of Copenhagen, Denmark
12:25 Is two better than one? Multitarget epigenetic inhibitors• Dual HDAC plus kinase inhibitors• Dual HDAC inhibitor plus receptor ligand• Dual epigenetic targetingProf. A. Ganesan, Professor of Chemical Biology, University of East Anglia, Norwich, UK
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12:50 Probing genome readers: the generation of an in vivo active bromodomain inhibitor for BRD9• The BAF complex is a potential target in cancer therapy• Structure based drug design of a selective inhibitor of BRD9• On-target chemical inhibition of Brd9 limits the proliferation of acute myeloid leukemia cellsDr. Manfred Koegl, Director Oncology Research, Boehringer Ingelheim, Vienna, Austria
13:15 Lunch – Networking – Poster presentation and One to One Meetings
14:15 Presentation by Diagenode
Cancer and Neurodevelopment
14:45 Targeting DNA methylation in neuropsychiatric disease; instructions from cancer epigenetics • DNA methylation mediating the impact of early exposures on behavioral phenotypes• Strategies of epigenetic therapeutics in cancer guiding approaches to neuropsychiatry• Epigenetic strategies towards treatment of behavioral disorders: addiction as a modelDr. Moshe Szyf, Glaxo Smith Kline and James McGill Professor, Department of harmacology and Therapeutics, McGill University Medical School, Canada
15:10 Development of LSD1 inhibitors for the treatment of oncological and neurodegenerative disease• Development of ORY-1001 and ORY-2001• Identification of the drugs’ modes of action• Status of ongoing clinical researchDr. Tamara Maes, Chief Scientific Officer, Oryzon, Spain
15:35 Design and Development of a Novel HDAC6-Selective Inhibitor, KA2507, for Hematological Cancer Treatment and Solid Tumor Immunotherapy
• Orally-active, selective small molecule HDAC6 inhibitor• Cancer ImmunotherapyProf. Stephen Shuttleworth, CSO, Karus Therapeutics, UK
16:00 Afternoon Refreshments | Poster Presentation | Networking
16:40 A “library-on-library” screening approach to identify small-molecule ligands of methyl-lysine reader proteins • Methyllysine readers• Chemical probes• Protein arraysProf. Dr. Gianluca Sbardella, Associate Professor of Medicinal Chemistry, Head of EpigeneticMedChemLab, Università di Salerno, Italy
Bioinformatics Development in Epigenetics
17:05 A computational approach for identification of protein-RNA interactions uncovers direct binders of Xist lncRNA• Global Score algorithm to calculate interactions of proteins and lncRNAs at nucleotide and amino acid resolution• Investigating protein binding to the Xist lncRNA, which orchestrates X Chromosome inactivation• Validating calculations by means of enhanced individual nucleotide CLIP method (eCLIP)• Testing method against a number of nucleotide-binding proteinsDr. Gian Gaetano Tartaglia, Group Leader, gene Function & Evolution, Centre for Genomic Regulation (CRG), Barcelona, Spain
17:30 Closing Remarks by the Chair
17:35 End of Conference
