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Canine Mast Cell Tumours
Mast Cell Tumours
• 16-21% of all cutaneous tumours• Primarily a disease of older dogs • No gender predilection• Several breeds have an increased
incidence
Brodie
• 6 year old, male neutered Labrador
• 8x5cm mass on the right flank
• Clinical exam:– BAR– HR 80 bpm– LNs not enlarged – Abdominal palpation
was comfortable
Diagnosis
• Cytological assessment of FNA• Histopathology– Patnaik Grading System– Kiupel Grading system
Patnik Grading System
Kiupel Grading System
• Differentiates MCTs into either high or low grade based on:– At least 7 mitotic figures in 10 hpfs– At least 3 multinucleated cells in 10 hpfs– At least 3 bizzare nuclei in 10 hpfs – Karyomegaly
Staging
• Haematology• Biochemistry • Abdominal ultrasound• Splenic FNA• Thoracic radiographs
Abdominal Ultrasound
Abdominal Ultrasound
Abdominal Ultrasound
Abdominal Ultrasound
Thoracic Radiographs
Treatment – Low Grade (I and II)
• Surgery with wide margins• Amputation • Cytoreductive surgery and
radiotherapy• Cytoreductive surgery and
chemotherapy
\
Treatment – High Grade (III)
• Wide surgery and chemotherapy +/- radiotherapy
• Chemotherapy options are – Vinblastine and Prednisolone– Lomustine– Tyrosine Kinase inhibitors (Masitinib or
Toceranib)
Management
• Re-evaluate regularly for local reoccurrence or metastases
• Local site and regional lymph node evaluation
• Complete physical exam • Aspiration of any new cutaneous
masses or enlarged lymph nodes
Acknowledgements
• Oncology department• Soft tissue department
References
• Dobson J, Duncan B and Lascelles X (2003) BSAVA Manual of Canine and Feline Oncology Second Edition. BSAVA Withrow and MacEwan Small Animal Clinical Oncology Fifth Edition. Elsevier Saunders
• Bowlt K, Starkey M and Murphy S (2014) Cutaneous Mast Cell Tumours in Canines – diagnosis and staging. Veterinary times 38, 29-30
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