Synaptic Glomerulus Afferent terminals on granular layer Mossy
Fiber Rosette -- afferent fibers except inferior olivary input --
2/3 of medullary center Granular Cell Dendrite -- main afferent
input Golgi Cell Axon -- synapse on granule cell dendrite -- GABA
(inhibitory) - Surrounded by Astrocyte Foot Process Cerebellum
Internal Configurations
Synaptic Glomerulus
Classification by Phylogenetic and Ontogenic Development
Archicerebellum Paleocerebllum Neocerebellum Classification by
Afferent Connection Vestibulocerebellum Spinocerebellum
Pontocerebellum Classification by Efferent Connection Vermis
Paravermal Region Cerebellar Hemisphere Cerebellum
Classifications
Efferent Connections : 1. Superior Cerebellar Peduncle
Cerebellothalamic fiber - from 3 deep nuclei to VPLo, VLc, CL
Cerebellorubral fiber - from nucleus interpositus and dentate
nucleus ascending portion of uncinate fasciculus of Russell 2.
Inferior Cerebellar Peduncle Fastigiovestibular fiber descending
portion of uncinate fasciculus of Russell Cerebellum
Connections
MLF Main Connections of the Vestibulocerebellum lower motor
neuron LMN vestibulospinal tract FASTIGIAL NUCLEUS Vestibular Organ
Floculonodular Lobe Vermis ARCHICEREBELLUM VESTIBULAR NUCLEUS
Main Connections of the Paleocerebellum lower motor neuron
SPINAL CORD rubrospinal tract NUCLEUS INTERPOSITUS Inferior Olivry
Nucleus ANTERIOR LOBE PARAVERMAL ZONE PALEOCEREBELLUM RED NUCLEUS
spinocerebellar tract
CEREBRAL CORTEX DENTATE NUCLEUS Main Connections of the
Neocerebellum lower motor neuron LMN pyramidal tract POSTERIOR LOBE
CEREBELLAR HEMISPHERE THALAMUS NEOCEREBELLUM Pontine Nucleus
upper motor neuron UMN BASAL GANGLIA Pyramidal Tract and
Associated Circuits lower motor neuron UMN pyramidal tract
Cerebellum
Reticular Formation CEREBELLUM Cerebellum and Automatic Motor
Control Lower Motor Neuron (LMN) Motor Cortex Red Nucleus
Vestibular Nucleus Proprioceptors
Corticonuclear Connections A zone ---------- fastigial nucleus
medial vestibular nucleus B zone ---------- lateral vestibular
nucleus C 1 , C 3 zone --- emboliform nucleus C 2 ----------------
globose nucleus D 1 ---------------- parvocellular portion of
dentate nucleus D 2 ---------------- magnocellular portion of
dentate nucleus Cerebellum Connections
Olivocerebellar Connections Caudal portion of medial and dorsal
accessory olivary nucleus ----------------- vermis of cerebellar
cortex (A and B) fastigial nucleus vestibular nucleus Rostral
portion of medial and dorsal accessory olivary nucleus
----------------- paravermal region (C 1 , C 2 , C 3 ) nucleus
interpositus Principal Inferior Olivary Nucleus -----------------
cerebellar hemisphere (D 1 , D 2 ) dentate nucleus Cerebellum
Connections
medial and dorsal accessory olivary nucleus caudal portion
rostral portion Principal Inferior Olivary Nucleus
Cerebellum Function Maintenance of Equilibrium - balance,
posture, eye movement Coordination of half-automatic movement of
walking and posture maintenace - posture, gait Adjustment of Muscle
Tone Motor Leaning Motor Skills Cognitive Function
Balance
Motor Skill Pablo Casals
Cerebellum Clinical Syndromes Ataxia : incoordination of
movement - decomposition of movement - dysmetria, past-pointing -
dysdiadochokinesia - rebound phenomenon of Holmes - gait ataxia,
truncal ataxia, titubation Intention Tremor Hypotonia, Nystagmus
Archicerebellar Lesion : medulloblastoma Paleocerebellar Lesion :
gait disturbance Neocerebellar Lesion : hypotonia, ataxia,
tremor
Posture Gait Ataxia Tremor
Cerebellar Ataxia Ataxic gait and position: Left cerebellar
tumor a. Sways to the right in standing position b. Steady on the
right leg c. Unsteady on the left leg d. ataxic gait a b c d
Cerebellar tumors on vermis - Truncal Ataxia - Frequent Falling
The child in this picture: - would not try to stand unsupported -
would not let go of the bed rail if she was stood on the floor.
Cerebellar Medulloblastoma