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The Cornea Specialist CompanyYour technology partner in refractive-cataract surgery and vision care

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Reducing Refractive SurprisesTotal Corneal Astigmatism

Patient Outcomes

Topography

Keratometry

Ocular Surface

Surgically Induced

AstigmatismPosterior Corneal Surface

Orientation of Toric Lens

Postoperative Results

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1. Total Corneal Analysis

2. Ocular Surface Diagnostics

3. Iris Registration for Laser Surgical Guidance

4. Integrated Surgical Workflow

5. Data Mining based on Population Characteristics

6. Pro-active Clinical Solutions

Preparing for refractive lens surgeryCassini provides highly valuable pre-op information

Anterior and Posterior Cornea analysis

Including dry eye diagnosis module (WIP)

Wireless integration with Lensar Streamline

Seamless integration with TrueVision, Leica IOL Compass, Cirle Navigation

Cassini Insight data mining and cloud-based solutions (WIP)

e.g., dry-eye OTC agents and pharmaceuticals

Cassini Total Corneal AstigmatismGPS-like information from anterior & posterior corneal surfaces

Multi-colored LED point-to-point ray tracing

2nd Purkinje point-to-point ray tracing technology

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Cassini Cornea MeasurementPatented Multi-color LED Ray Tracing

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Non-contact ocular surface diagnosisVirtual Corneal Staining

Virtual Staining from

Multi-Colored LEDs

Same patient,

4 months after Xiidra

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Cassini: An Integrated Ecosystem Seamless integration between clinic and OR

Pre Op diagnostics &

IOL selection

Post Op Analysis &

SIA ManagementRefractive

Outcomes

Accuracy and

Efficiency

Femtosecond laser

assisted astigmatism

correction

Toric guidance &

verification

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Lensar Streamline Iris registration with CassiniSeamless interaction between clinic and OR

Femtosecond iris registration to

correct for cyclotorsion

Cassini TCA Means Accurate Diagnosis94% ≦ 0.5D Postoperative Manifest Refractive Cyclinder

ORA - Hatch et al

JRS 2015

n = 37

Lenstar + Barrett

n = 50Cassini TCA

n = 50

<0.5D <0.25D <0.5D <0.25D <0.5D <0.25D

94%

84%

78%74%

54%

38%

Retrospective study - Elizabeth Yeu MD Hatch et al JRS 2015

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Premium procedures represent real growthCassini Serves a Significant Part of the Premium Cataract Market

Since the launch in 2013, Cassini has provided corneal diagnosis for

more than 300,000 cataract patients, with 50,000 in Q1 20171

0

10,000

20,000

30,000

40,000

50,000

Q4 Q1'14

Q2 Q3 Q4 Q1'15

Q2 Q3 Q4 Q1'16

Q2 Q3 Q4 Q1'17

Pre operative measurements per quarter

2014 2015 2016

1 Based on installed base multiplied by average number of patients diagnosed based on data collection from sites

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Cassini: a technology partnerMultiple applications from high value cataract surgery to high volume dry eye

diagnosis and contact lens fitting

1. Refractive-cataract surgery

Drive premium procedures and adoption of premium IOL’s

2. Surgical guidance for fs laser and IOL placement

Streamline image-guided and automated surgical procedures

3. Dry Eye Disease and contact lens fitting

Low cost (handheld) application for high-volume markets