Why Current Trials Are Not Yielding Results?

Improve Clinical TrialParticipationWith Mobile Apps

Mobile apps are pivotal to patient recruitment and retention in clinical trials. We have done research on changing trends and challenges within clinical trial patient recruitment & retention. Here are a few insights on what sponsors & CROs are missing.

Challenges In Patient Recruitment

60% 72% 28%

Web-BasedSources

Patients Alreadyon CROs

New Visitorson CROs

46% Internet20% PhysicianReferrals

36% Media 21% Mail32% E-mail

TraditionalRecruitment Methods

Inadequate knowledge aboutavailable treatment options

Lack of awareness and access toclinical trials

Lack of effective communicationand cultural differences

Poor understanding of the riskand benefits of clinical trials

Fear and distrust or suspicions ofresearch

As patient recruitment & enrollment tools are critical to the success for any clinical trial, retaining patients in clinical trials is equally challenging. Keeping patients on a protocol from start to finish presents its own set of challenges, and has following focus areas:

Apple’s ResearchKit - ResearchKit is being touted as having immense implications for the future of clinical trials. ResearchKit provides a framework for developers to build apps that help in managing trial process, contribute trial data, ease patient enrollment and conduct studies for clinical research. Clinical trial apps created with ResearchKit are already producing medical insights and discoveries at a pace and scale never seen before.

Lengthy Trials Complex Trial Designs Lack of Motivation

Unexpected Risks

Delayed Reimbursements forStudy Costs to Participating Patients

Adverse Events Poor Communication ofTrial Outcomes

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70

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30%

80%

50%

32%

69% 80% studies fail to meet recruitment timelines

30% of phase III terminations are caused by enrollment difficulties

50% of research sites enroll one or no patients

69% of non-participation is lack of awareness about the trial taking place

32% of the trial budget is patient recruitment cost

100%

Attraction• Provide relevant study material to the participants• Contact participants based on geographical proximity to relevant sites• Share trial details via email, sms, facebook & twitter etc.

Engagement• Study site, give medication reminders & refill alerts with native calendar integration• Travel assistance tips for study site• Use multilingual platform• Inspiration & information tips & messages

Enrollment• Use videos to better explain study enrollment & protocol criteria• Surveys for participants to fill in initial enrollment criteria data• Provide means to easily contact study site from within the app

Retention• Gaming features to engage younger, tech savvy participants• In-app incentives that can be redeemed at desired stages of the study• Chat facility with online support groups• Customizable modules for a personalized experience

ResearchKit focuses on following aspects:

Inform about trial study Screening & Enrollment Collect data fromm-health apps & other devices

Create surveys Data Management& Analysis

Where Do Your Patients Come From?

Impact On Trial Outcomes Due To Trial Process Delays

How Mobile Can Help?

Apple’s Research KitValue Adding Technology To Mobile Apps

• e-Recruiting Using Digital Platforms, Social Media and Mobile Technologies to Improve Clinical Trial Enrollment - inventivhealth.com• CISCRP - clinical trial information seekers• The Pulse on Global Trials By Matthew Howes• Appliedclinicaltrialsonline.com/recruitment-roles• Elizabeth Wilson - Tips for Success - Patient Recruitment in Clinical Trials• Patient Recruitment & Clinical Vendor Fees Top Clinical Trial Cost Drivers - cuttingedgeinfo.com• Apple ResearchKit- www.apple.com/in/researchkit/• Macworld.com - Stanford's ResearchKit app

Source

www.diaspark.com/mobility

Stanford University was able to recruit 11,000 participants for a heart disease study in just 24 hours using Apple’s ResearchKit.