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WATER SOLUBLE VITAMINS
Dr Vijay Marakala MBBS.,MD.Assistant professor
BiochemistrySIMS&RC
WATER SOLUBLE VITAMINS
BIOTIN
BIOTIN - CHEMISTRY
Imidazole ring
Thiophene ring Valeric acid
BIOTIN - SOURCES
It is widely distributed in
the foods
Liver, kidney, vegetables and
egg yolk are important
source
Biotin also synthesized by
intestinal bacteria
BIOTIN - RDA
RDA 20=30µg/day
BIOTIN - ABSORPTION
It is absorbed in the small
intestine and reaches liver
and other tissues through
circulation
BIOTIN - FUNCTIONS
Biotin is a coenzyme of carboxylase
reactions
4 enzymes in the body require
biotin
BIOTIN - FUNCTIONS
Acetyl CoA carboxylase
Propionyl CoA carboxylase
Pyruvate carboxylase
β Methyl crotonyl CoA carboxylase
BIOTIN
BIOTIN DEFICIENCY
Biotin deficiency is rare in humans because it is present in most of the common foods.
However experimentally induced biotin deficiency symptoms in man are dermatitis, alopecia, depression, muscular pain and anemia
BIOTIN - ANTAGONISTS
AVIDIN