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This presentation is a continuation to Urinary tract infections - Part I shared earlier. UTI - II discusses various forthcoming plants for UTI treatment.
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Forthcoming plants
for
UTI treatment
(UTI – II)
Presented by
Dr. Sudhakar Kokate
Director PPRC, India
Plant categories of UTI treatment
Botanical diuretics
Urinary anti-septic and anti-adhesion herbs
Botanicals with anti-nephrotoxic activity
Plants to relieve from benign prostatic hyperplast
(BPH)
Phyto-derivatives against Prostate cancer
PPRC/INDIA 01
My Attitude
Researchers from different labs globally need to
work closely together, discuss problems frequently
and analyze the results instantly.
Herbal medicine research -
1. should be organized
2. consistent team work is absolutely vital.
PPRC/INDIA 02
Data by WHO % Use of herbal medicines
Africa …. 80
China …. 30 – 50
Europe N. America …. > 50
Germany …. 90
India …. 40 – 70
Global market for
herbal medicines …. > $ 60 bn / yr
….. And growing faster
PPRC/INDIA 03
I.
Phyto Diuretics
PPRC/INDIA 04
Solidago virgaurea L. : European goldenrod
Solidago canadensis : Canadian goldenrod
S. gigantea Aiton : Early goldenrod
PPRC/INDIA 05
These contain saponins and tannins (Weiss 1985)
Multiple compounds contribute to actions
(Okpanyi et. al. 1989)
S. gigantea 60% ethanol extract on animal study
(Leuschher 1995)
S. virgaurea extracts practised to prevent
formation of kidney stones and to help in
removing urinary gravel (Blumenthal et. al. 1998)
PPRC/INDIA 06
Levisticum officinale
PPRC/INDIA 07
Levisticum officinale
Also called Lovage root
Family: Apiaceae
Good diuretic (Weiss 1985)
Major active principle: Terpenoids, Iso-valeric acid,
Angelic acid, Coumarins
Approved by the German Commission E for use in
lower UTI and urinary gravel. (Blumenthal et. al. 1998) PPRC/INDIA 08
Petroselinum crispus
PPRC/INDIA 09
Petroselinum crispus
Also called Parsley
The root / fruit is used as a Diuretic
Folk remedy since the ancient times (Yarnell 2002)
Active principles: Terpenoids, Apicol, Flavanoids,
Apigenin
This herb also shows carminative and calcium
channel – blocking activity in vitro (Neuhaus –
Charlisle et. al. 1993)
PPRC/INDIA 10
Urtica dioica
PPRC/INDIA 11
Urtica dioica
Also called Stinging nettle
Parts – Leaves, Seeds
Used as – Mild diuretic, support for urinary tract
functions, internal anti-inflammatory and roots as
benign prostatic hyperplasia
Aqueous extract have diuretics and natriuretic
effects (Tahri et. al. 2000)
PPRC/INDIA 12
Ononis spinosa
PPRC/INDIA 13
Ononis spinosa
Also called Spiny restharrow
Chemicals: Phenol, Lectin, Triterpenoid, Volatile
oils – Trans anethole, Camphor, Menthol,
Estragole, Borneol
Family: Fabaceae
Roots: Diuretic (Weiss 1985)
PPRC/INDIA 14
Equisetum arvense
PPRC/INDIA 15
Equisetum arvense
Also called Horsetail
Active principle: Silicic acid, Silicates
Astringent effect on the genito-urinary system
(Steenkamp 2003)
PPRC/INDIA 16
Forthcoming
Diuretic plants
PPRC/INDIA 17
Apium graveolens: (celery) fruits
Taraxacum officinale (Dandelion) leaves
Parietaria judaica (Pellitory-of-the-wall)
Galium aparine (Cleavers)
Chimaphila umbellata (Pipsissewa)
Asarum europaeum (Asarabacca)
Carlina vulgaris (Caroline thistle)
PPRC/INDIA 18
Apium graveolens
PPRC/INDIA 19
Taraxacum officinale
PPRC/INDIA 20
Parietaria judaica
PPRC/INDIA 21
Galium aparine
PPRC/INDIA 22
Chimaphila umbellata
PPRC/INDIA 23
Asarum europaeum
PPRC/INDIA 24
Carlina vulgaris
PPRC/INDIA 25
Rosmarinus officinalis (Rosemary)
Centaurium erythraea
Spergularia purpurea
Ananas comosus
Carica papaya
Cyperus rotundus
PPRC/INDIA 26
Rosmarinus officinalis
PPRC/INDIA 27
Centaurium erythraea
PPRC/INDIA 28
Spergularia purpurea
PPRC/INDIA 29
Ananas comosus
PPRC/INDIA 30
Carica papaya
PPRC/INDIA 31
Cyperus rotundus
PPRC/INDIA 32
References
Weiss, 1985
Halouri et. al. 2000
Jounad et. al. 2001
Sripanidkulchai et. al. 2001
PPRC/INDIA 33
Urinary antiseptic
&
anti-adhesion plants
PPRC/INDIA 34
Arctostaphylos uva-ursi
PPRC/INDIA 35
Arctostaphylos uva-ursi
Also called Uva-ursi
Active principle: Glycoside arbutoside – Arbutin
Used for lower urinary tract infections by
Commission E. 1998 (Blumenthal et. al.)
>7 pH …. Urine environment Arbutin converts
hydroquinone (caution – carcinogenic) which
kills bacteria (Yarnell 2002)
PPRC/INDIA 36
Juniperus spp. fruit
PPRC/INDIA 37
Juniperus spp. fruit
Useful in digestive disorders, kidney and bladder
problems
Volatile oil contains > 100 compounds i.e. alpha
and beta pinene, myrecene, limonene, sabinene
and alcohol, terpinene-4-ol (Clark et. al. 1990)
Animal studies shows that extracts increase
urinary volume PPRC/INDIA 38
Juniperus spp. fruit
Additionally terpinen-4-ol acts as diuretic
Excessive doses of Juniper on animals show
kidney irritation (Schilcher and Leuschner 1997)
PPRC/INDIA 39
Echinacea spp.
PPRC/INDIA 40
Echinacea spp.
E. purpurea – immunostimulating property in
UTI (Kligler 2003)
Three sp. Effective – E. purpurea
E. angustifolia
E. pallida
Purple coneflower is native to North America
PPRC/INDIA 41
Hydrastis canadensis
PPRC/INDIA 42
Hydrastis canadensis
Also known as Goldenseal
Active principle in roots: Hydrastine, Berberine
Berberine: no side effects, compared with
antibiotics, it blocks adhesion of bacteria to
epithelial cells (Subbaiah and Amin 1967, Amin et.
al. 1969)
Anti-microbial activities against bacteria, fungi and
protozoa PPRC/INDIA 43
Hydrastis canadensis
Protective effect against several micro-organisms
including:
E. coli
Streptococcal bacteria
Chlamydia and Proteus sp.
Salmonella typi
Entamoeba histolytica
(Lahiri & Dutta 1967, Mahajan et. al. 1982, Sun et. al. 1988 b)
PPRC/INDIA 44
Agathosma betulina
PPRC/INDIA 45
Agathosma betulina
Also known as Buchu
Used against UTI since the ancient times
Native to South Africa
Effective in treating cases of cystitis, nephritis,
catarrh of the bladder, urethritis
Active principle: Monoterpene disophenol
‘buchu’ PPRC/INDIA 46
Agathosma betulina
In-vitro experiments show that flavonoids exhibit
anti-inflammatory effects
Today, a tincture is used in treatment of genital
and UTI such as kidney stones, prostatitis
PPRC/INDIA 47
Zea mays
PPRC/INDIA 48
Zea mays
Also known as Cornsilk
Chemicals: saponins, tannins, alkaloid, hordenine,
sterols, stigmasterol, allantoin, polyphenols, Vitamin
K, B and C
It soothes and relaxes the lining of ureter, bladder
and urethra
Relieving irritation and improving urine excretion
(Steenkamp 2003) PPRC/INDIA 49
Thank You!!
“BE WITH US”