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ETIOLOGY Contact with cat faeces.
Uncooked meat.
Contaminated vegetables & fruits.
Contaminated knives & utensils.
Infected organ transplantation or blood transfusion.
ACQUIRED TOXOPLASMOSIS CONGENITAL TOXOPLASMOSIS
Fever Convulsions
Malaise Chorioretinitis
Lymphadenopathy{submandibular} Intra cerebral calcifications
Muscle & joint pain Mental retardation
Jaundice
Differential Diagnosis Lymphoma
Metastatic cancer
Histoplasmosis
Infectious mononucleosis
Catscratch disease
Histologic features Preserved Lymphnode architecture
Accumulation of Eosinophilic Macraphages
Epitheliod histiocytes
immunoblast
TREATMENT Pyrimethamine + sulfadiazine
For AIDS patients = Atovaquone + clindamycin.
Congenital = Spiramycin.
ETIOLOGY Saprobic organism present in soil , water & organic
debris
Inhalation of spores.
Nosocomial infection.
Clinical features Sinusitis
Aspergilloma
Antrolith
Fever , chest pain , Dyspnoea , coughing blood
Systemic failure -death
HISTOPATHOLOGIC FEATURES Branching , septae hyphae 3 to 4 um diameter.
Necrosis .
Granulamatous inflammatory response.
Large pools eosinophilic inspissated mucin
Interpersed lymphocytes&eosinophils.