The SPHS Capacity Building Sessions - "Water and Pharmaceuticals" Presentation by SIWI

© SIWI | siwi.org

Water and Pharmaceuticals Reducing Wastewater, Increasing Efficiency Nicolai Schaaf, SIWI

© SIWI | swedishwaterhouse.se

• There is more to Water and Pharmaceuticals than scaling up wastewater treatment.

• ”Value added water” focuses on resource recovery rather than on resource depletion for added treatment.

• Invitation to explore your company’s Water-Energy-Chemicals-Nexus

What do we want?


Water and Development SIWI and Swedish Water House


Cluster group with Swedish Stakeholders

SIWI and Pharmaceuticals

Production

Wastewater

Consumption

Procurement Monitoring


Mere Wastewater treatment?

PEC > PNEC

PEC < PNEC


SIWI and Pharmaceuticals Industry


Raw water sourcing

Inlet water typical value: € 0.1 – 0.6/m3 Typical storage at 20-300C

Cooling of soft-flow machines

Cooling circuit

Water absorbs heat and is at 50-600C Value of hot water: € 2-3/m3

Reverse Osmosis pre-treatment

Value: € 1-2/m3 TDS < 150 ppm Typical storage at 20-300C

Wet-process circuit Pre-process (Ready for Dyeing) Value added:

Chemicals / enzymes + Heat Value if water in process €20/m3 in the case of Wovens €14/m3 in the case of Knits

Discharge

Treatment cost: € 0.4- 1/m3

Dyeing

Value added: Dyes, chemicals and auxiliaries + heat Value of water in dye bath € 70/ m3 in the case of Wovens € 50/m3 in the case of knits

Value of condensate (distilled water) recovered: € 6-8 /m3 80-900C

Boiler storage

Steam generation

Value: € 4-5/m3 TDS < 150 ppm Typical storage at 70-800C

Heating circuit

Value of steam: € 11-15/m3

.

Introducing Value-added Water

Reuse hot water from soft flow cooling water in process

Reuse process water

Reuse caustic wash liquor or recover caustic

Re-vectoring and recovering

high value water at the

Water-Energy-Chemicals-Nexus:

Water as a resource carrier

(priced accordingly)

Develop the economic case for

interventions


• Water usage in cooling towers/utilities represents the single largest water usage group accounting for ~65 percent of the total water usage

• Steam used to carry heat in some processes

Carry/reduce heat

• Process water usage is presently at about 25 percent of the total water usage.

• Factories making active ingredients generate 200 pounds of waste for every pound of active pharmaceutical ingredient produced

Solvent to carry chemicals and

waste

How efficient is YOUR water usage?


• Self assessments

• Individual follow up and packages

• Be prepared for future regulative and market dynamics

Benchmarks as a competitive tool

© SIWI | siwi.org

Thank you for your attention!

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Potable water

• Potable water, or water intended for human consumption, is also used as feed water for the production of purified water and water for injections.

• Potable water may be used to rinse product-contacting surfaces of equipment. The same could be treated to reduce its microbial content.

Purified Water (PW)

• Purified Water in bulk used as an excipient in the preparation of non-sterile products and as a starting material in the preparation of water for injection and pharmaceutical-grade pure steam. It is also used for rinsing purposes (cleaning of containers) and in the preparation of cleaning solutions.

• Purified Water in containers (bulk) that has been filled and stored in conditions designed to assure the required microbiological quality. It must be free from any added substances.

Highly Purified Water (HPW)

• Is used in the preparation of medicinal products where bacterial endotoxins need to be controlled, except where water for injection is required. Current methods for the preparation include double-pass reverse osmosis, reverse osmosis combined with ultrafiltration and distillation.

Water for Injection (WFI)

• Sterilized Water for injection used for dissolving or diluting substances or preparations for parenteral administration.

• Water for injection in bulk used in the manufacture of parenteral and ophtalmic products. It is also used for final rinsing of containers (e.g. primary packaging materials) and manufacture of these products.

Pure Steam (PS)

• Pure steam is evaporated above 100 °C and used for humidification and sterilisation of e.g. porous goods. The level of steam satura-tion or dryness, and the amount of non-condensable gases are to be determined by the Pure Steam application. The condensate must comply with the respective WFI requirements.

What is the value of different form of process water requirements?

Health & Medicine

The SPHS Capacity Building Sessions - "Water and Pharmaceuticals" Presentation by SIWI