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Rose-Hip Vital™with Galactolipid (GOPO®)
The future of Arthritis pain reliefThe future of Arthritis pain reliefThe future of Arthritis pain reliefThe future of Arthritis pain relief
An overview
Rose-Hip Vital™
Keeping you jumping for joy!
Rose-Hip VitalTM is a clinically documented
product, produced by Hyben Vital, Denmark,
marketed by Rose-Hip VitalTMAustralia (Pty) Ltd,
which may help alleviate some of the
symptoms related to osteoarthritis (OA) and
rheumatoid arthritis (RA).
Rose-Hip Vital™ – The Story
• Prof Kaj Winther, MD. DMsci. and Prof Arsalan Kharazmi, University Hospital, Copenhagen, were contacted
• First in vitro studies - the results were impressive
• Rose-Hip VitalTM had anti-inflammatory effect
• Several clinical studies of Rose-Hip VitalTM on human beings
• Dansk Droge added pharmaceutical production
and marketing expertise to Rose-Hip VitalTM.
Rosehip powder is the subject of numerous clinical trials, abstracts and research papers
including:
THETHETHETHE SCIENCE BEHIND ROSE-HIP VITAL™
ABOUT ROSEABOUT ROSEABOUT ROSEABOUT ROSE----HIP VITALHIP VITALHIP VITALHIP VITAL™™™™ with with with with
GALACTOLIPID (GOPOGALACTOLIPID (GOPOGALACTOLIPID (GOPOGALACTOLIPID (GOPO®®®®))))
• Manufactured in Denmark by Hyben-Vital
• Sourced from 100% pure and natural rosehip – a natural anti-inflammatory
• Unique compound in Rose-Hip Vital™ is Galactolipid (GOPO®) (glycoside of mono and diglycerol) which is isolated from the active compound Rosa Canina L, which acts as a natural anti-inflammatory
• When dried at a certain temperature Galactolipid (GOPO®) is released, which helps to reduce inflammation by discouraging large numbers of white blood cells from accumulating in the joint
• Powerful antioxidant – Vitamin C absorbed more effectively than synthetic version
• Backed by over 30 clinical and scientific studies focussing on Osteoarthritis and Rheumatoid Arthritis
• Rose-Hip Vital™ is the only product available in Australia which tests for the patented
compound Galactolipid (GOPO®)
GALACTOLIPID (GOPOGALACTOLIPID (GOPOGALACTOLIPID (GOPOGALACTOLIPID (GOPO®) ) ) ) –––– How it worksHow it worksHow it worksHow it works
• Some white blood cells in the body contain granules which enable them to
‘clean’ an inflamed Osteoarthritic joint by destroying the bacteria in it.
• Too many of these white blood cells can actually wear down the tissue
cartilage. In large numbers they can also produce chemical enzymes and
toxic free-radicals, which cause even more tissue damage.
• The accumulation of white blood cells combined with the release of
chemical substances causes pain and inflammation in the joint i.e.
Arthritis.
• The more inflamed the joint becomes, the more the white blood cells are
attracted to it, so the process is self-maintaining.
• The active compound Galactolipid (GOPO®®®®) works by discouraging large
numbers of white blood cells from accumulating in the joint, therefore
breaking the vicious cycle and alleviating and reducing joint damage.
INGREDIENT PROFILE– Rose-Hip Vital™ with Galactolipid (GOPO®)
• 100% pure and natural rosehip
• Contains high level of active compound Galactolipid (GOPO®) using special
drying patented process
• Source of natural Vitamin C – absorbed more effectively than synthetic Vitamin C
• Free of yeast, gluten, wheat, dairy and lactose
• Contains no GM ingredients
• Non-allergen
• Does not contain shellfish
• Powder form suitable for vegetarians
• Shown to be well tolerated
• No gut irritation as found in common pharmaceutical drugs
GCP STUDIES
• 94 patients with OA in knee/hip
• 112 patients with OA in various joints
• 100 patients with OA in knee/hip (Norwegian)
DANISH STUDY
94 patients with Osteoarthritis in the hips or/and knees
by Kaj Winther, MD. DMsci
Department of Clinical Biochemistry, Copenhagen County Hospital Gentofte, Denmark
Published August 2005 in”Scandinavian Journal of Rheumatology”
AIM
• To test if a herbal remedy made from the hips of a subtype Rosa canina (trade name Rose-Hip Vital™)
might reduce symptoms of osteoarthritis and consumption of rescue medication in patients suffering from osteoarthritis of the hip or knee.
• To test the tolerability of the product during a 3 month treatment period.
REDUCTION IN WOMAC PAIN SCORE ON THE YES/NO BASIS IN
PATIENTS AFTER 3 WEEKS PLACEBO OR 3 WEEKS Rose-Hip VitalTM
% R
espo
nders
to t
reatm
ent
More than 8 out of 10 responded with a reduction in Pain
Score while on Rose-Hip Vital™. *P<0.0039 vs. placebo
Rose-Hip VitalTM
Placebo
82% 49%
P< 0.05 (statistical significance)
PATIENTS EVALUATION OF DISEASE SEVERITY (PGAD) AFTER 3
MONTHS ROSE-HIP VITAL TREATMENT AND AFTER 3 MONTHS ON PLACEBO
A significant reduction in PGAD was observed during Rose-Hip VitalTM
treatment. *(p<0.001 within the Rose-Hip VitalTM group and p<0.031 vs. Placebo)
*
14.1 ±±±± 28.1 7.8 ±±±± 28.8
Delt
a
D
elt
aR
ed
ucti
on
In
cre
ase
Placebo
Pati
en
ts e
valu
ati
on
of
the d
iseas
e
Rose-Hip VitalTM
P< 0.05 (statistical significance)
• 112 patients with Osteoarthritis in the various joints
• K. Winther, MD. DMsci, Department of Clinical Biochemistry, Copenhagen County Hospital Gentofte, DK
• A.Kharazmi, Professor, Department of Clinical Microbiology, University Hospital, Copenhagen, DK
E. Rein, Institute for Clinical Research
Published in July 2004 in
”Phytomedicine”
DANISH STUDY
Flow chart
PLACEBO PLACEBOGroup B
Group A3 months 3 months
Rose-Hip VitalTM
+
Rose-Hip VitalTM
This study showed the same
positive result when measuring pain and stiffness as the study on
94 patients with OA in hip/knee.
NORWEGAN STUDY
• 100 patients with Osteoarthritis in the hips or/and knees
• by Odd Warholm, MD. Department of Orthopaedic
Surgery, Vestfold Central Hospital, Tonsberg, Norway
• Published, January 2003 in
• ”Current Therapeutic Research”
Rose-Hip VitalTM
group
Placebo group
4 months treatment
4 months treatment
Method:
• 100 patients, all with an X-ray verified diagnosis of OA of the hip or knee, in a randomised, placebo- controlled, double-blind study. The Rose-Hip VitalTM group was given 5g of capsules daily for 4 months and the placebo group was given an identical amount of capsules.
• All patients were on a waiting list for either hip or knee surgery or on a list for final evaluation for surgery.
% R
es
po
nd
ers
to
tre
atm
en
t
2 out of 3 responded with a reduction in Pain Score
while on Rose-Hip VitalTM. P<0.035 for Rose-Hip VitalTM vs. placebo
65% 44%
Rose-Hip VitalTM
Placebo
P< 0.05 (statistical significance)
JOINT PAIN RELIEF
PASSIVE HIP JOINT MOVEMENTS
0
5
10
15
20
25
30
35
40
imp
rov
em
en
t %
Flexion External
rotation
Internal
rotation
Rose-Hip Vital TM
placebo
P = 0.003
P = 0.006
P < 0.001
P< 0.05 (statistical significance)
Consumption of NSAID after 4 months of treatment
-20
-15
-10
-5
0
5
10
Procent %P < 0.016
Rose-Hip Vital TM
14,6%
8,3%
Placebo
Incre
ased
Decre
ased 8,3%
Rose-Hip VitalTM Studies
• The GCP-studies show that Rose-Hip VitalTM reduces symptoms of OA due to:
• reduction of joint pain
• improvement of mobility in joints
• improvement in ADL (Active Daily Living)
• better mood and sleep quality
• reduction of consumption of NSAID - Paracetemol, Tramedoland Codein
• no side effects
Osteoarthritis and Cartilage
Review:
Does the hip powder of Rosa canina (rosehip) reduce pain in osteoarthritispatients? - A meta-analysis of randomized controlled trials
•R. Christensen M.Sc.t, E. M. Bartels Ph.D., D.Sc.tt, R. D. Altman M.D.,
Professor, A. Astrup Ph.D., M.D., Professoril and H. Bliddal M.D., Ph.D.t*
•The Parker Institute, Musculoskeletal Statistics Unit, Frederiksberg Hospital,
Denmark Copenhagen University Library, Denmark
•David Geffen School of Medicine, University of California, Los Angeles, CA
90024, USA
•Department of Human Nutrition, Faculty of Life Sciences, University of
Copenhagen, Denmark
2008
THE ACTIVE COMPOUND - GOPO®
• Anti-inflammatory agent
• Anti-oxidant agent
Galactolipid (2S)-1,2-di-O-[(9Z,12Z,15Z)-Octadeca-9,12,15-trienoyl]-3---ββββ-D-galactopyranosyl glycerol
O
CH2
CH
H2C
OH
OH
HO
CH2OH
O
1
O
O
O
CH3
CH3
O
• Anti-inflammatory agent
• Anti-oxidant agent
Galactolipid (2S)-1,2-di-O-[(9Z,12Z,15Z)-Octadeca-9,12,15-trienoyl]-3---ββββ-D-galactopyranosyl glycerol
GOPO® is the registered name for the compound isolated from the rose-hip subtype Rosa canina used in Rose-Hip VitalTM
GOPO® is a glycoside of mono- and diglycerol (GMDG)
GOPO® was identified by using a bioassay-guided fractionation.
THE ACTIVE COMPOUND - GOPO®
• Usage Patent
• GOPO®
• Manufacturing Process
INTERNATIONAL PATENTS
“The Impact of Rosehip on Pain and Stiffness in Patients Suffering from
Rheumatoid Arthritis”
Multicentre study – University Hospital of Berlin &
University Hospital of Copenhagen
STUDY DESIGN• Randomized controlled trial
• Double-blind
• Prospective 6 months treatment, 5 gr Rose-Hip Vital™ or placebo
• To investigate if a standardised powder (Rose-Hip VitalTM), made from husks and seeds of Rose-hip (Rosa canina), can reduce pain and stiffness in patients suffering from rheumatoid arthritis inaddition to usual care
STUDY AIM
PARTICIPANTS:•Inclusion:
•Men and Women, > 18 years, with rheumatoid arthritis
•Diagnosis according to revised 1987 American Rheumatic Ass. Criteria
Exclusion:
• Lupus erythematosus
• Allergy to plant products
• Pregnancy
• Kidney or liver disease
• Drug abuse
• Psychiatric disease
ENDPOINTS•Primary Outcome:
Difference 6 months to baseline
• HAQ
–Secondary Outcomes:
Difference 6 months to baseline
• DAS28
• Physician´́́́s Global Scale
• RAQoL and SF-12
• Pain medication
• Sore joints
Results - Characteristics of Participants
Treatment group (N=44)
Placebo (N=45)
Age (years) (mean±SD) 57.1 ± 10.6 56.1 ± 12.0
Female sex (%) 86 93
Disease duration (years) (mean±SD) 12.7 ± 9.2 13.0 ± 9.9
BMI (kg/m2) (mean±SD) 25.7 ± 4.3 25.2 ± 4.6
Education > 10 years (%) 36 51
Full-time or part-time employment (%)
36 39
Living alone (%) 30 23
Smokers (%) 23 11
-0.2
-0.15
-0.1
-0.05
0
0.05
0.1
0.15
0.2
0 3 6Months
HA
Q d
iffe
ren
ce
Active
Placebo
Results – HAQ Disease Index
p<0.032
Results – HAQ Patient`s Global Scale
-10
-8
-6
-4
-2
0
2
4
0 3 6
Months
HA
Q d
iffe
ren
ce
Active
Placebo
p=0.078
Results – Physician`s Global Scale
-20
-15
-10
-5
0
5
0 3 6
Months
Glo
ba
l s
ca
le d
iffe
ren
ce
Active
Placebo
p=0.012p=0.012
RESULTS: QUALITY OF LIFE
• SF-12 physical significantly improved in favour of active treatment (p=0.013)
• RAQoL significantly improved as the result of active treatment (p=0.043)
• SF-12 mental score remained unchanged
• Pain medication was identical in the two groups and did not differ during the course of the study
• The number of sore joints declined by 45% (p<0.040) in pp patients as a result of active treatment.
CONCLUSION
• Patients with RA benefited from additional treatment with standardized Rose-hip powder (Rose-Hip VitalTM)
• Per protocol analysis confirms these results
• Large, randomised trials are needed to confirm these promising results
•The present data indicates that Rose-Hip VitalTM, a standardized Rose-hip
powder manufactured by Hyben Vital, Denmark, improves joint flexibility and
reduces pain in patients with OA and RA.
TGA Approved Claims for Rose-Hip Vital™
Rose-Hip Vital™ may help:
• Temporarily relieve the pain of Arthritis, Osteoarthritis & Rheumatism
• Relieve inflammation and joint swelling
• Increase joint mobility
• Improve sleep when affected by joint discomfort
• Improve Osteoarthritis symptoms in the hands
• Improve the symptoms of lower back pain
POWDER
250
CAPSULES
DOSAGE for Rose-Hip Vital™
POWDER
DOSAGE: 2.5g powder (1 tspn),
twice per day for three weeks
MAINTENANCE: 2.5g (1 tspn) once
a day
CAPSULES
DOSAGE: 5 Capsules (2.5g) twice a
day for three weeks
MAINTENANCE DOSAGE: 5 Capsules
(2.5g) once a day
ARTHRITIS IN AUSTRALIAARTHRITIS IN AUSTRALIAARTHRITIS IN AUSTRALIAARTHRITIS IN AUSTRALIA• 3.8 million Australians suffer from OA; 400 000 suffer from RA.
• Australian Institute of Health & Welfare Report indicates 40% of sufferers use
Complimentary Therapies and Doctor referrals increasing.
• Consumers and Health Professionals looking for new innovations, with integrity,
backed by science, with demonstrated results.
• Trends indicate that there is significant support for Complimentary Therapies which
are backed by credible scientific studies.
INFLAMMATION AT WORKINFLAMMATION AT WORKINFLAMMATION AT WORKINFLAMMATION AT WORK
ABOUT ROSEABOUT ROSEABOUT ROSEABOUT ROSE----HIP VITALHIP VITALHIP VITALHIP VITAL™™™™ with with with with
GALACTOLIPID (GOPOGALACTOLIPID (GOPOGALACTOLIPID (GOPOGALACTOLIPID (GOPO®®®®))))
• Manufactured in Denmark by Hyben-Vital
• Sourced from 100% pure and natural rosehip
• Unique compound in Rose-Hip Vital™ is Galactolipid (GOPO®) (glycoside of mono and diglycerol) which is isolated from the active compound Rosa Canina L, which acts as a natural anti-inflammatory
• When dried at a certain temperature Galactolipid (GOPO®) is released, which helps to reduce inflammation by discouraging large numbers of white blood cells from accumulating in the joint
• Powerful antioxidant – Vitamin C absorbed more effectively than synthetic version due to high concentration
• Backed by over 30 clinical and scientific studies focussing on Osteoarthritis and Rheumatoid Arthritis
• Rose-Hip Vital™ is the only product available in Australia which tests for Galactolipid (GOPO®)
GALACTOLIPID (GOPOGALACTOLIPID (GOPOGALACTOLIPID (GOPOGALACTOLIPID (GOPO®) ) ) ) –––– How it worksHow it worksHow it worksHow it works
• Some white blood cells in the body contain granules which enable them to
‘clean’ an inflamed Osteoarthritic joint by destroying the bacteria in it.
• Too many of these white blood cells can actually wear down the tissue
cartilage. In large numbers they can also produce chemical enzymes and
toxic free-radicals, which cause even more tissue damage.
• The accumulation of white blood cells combined with the release of
chemical substances causes pain and inflammation in the joint i.e.
Arthritis.
• The more inflamed the joint becomes, the more the white blood cells are
attracted to it, so the process is self-maintaining.
• The active compound Galactolipid (GOPO®®®®) works by discouraging large
numbers of white blood cells from accumulating in the joint, therefore
breaking the vicious cycle and alleviating and reducing joint damage.
INGREDIENT PROFILE– Rose-Hip Vital™ with Galactolipid (GOPO®)
• 100% pure natural rosehip
• Contains high level of active compound Galactolipid (GOPO®)
using special patented process
• Source of natural Vitamin C – absorbed more effectively than
synthetic Vitamin C
• Free of yeast, gluten, wheat, dairy and lactose
• Contains no GM ingredients
• Does not contain shellfish
• Suitable and safe for most people
• No gut irritation as found in common pharmaceutical drugs
RECENT MEDIA COVERAGEEveryone’s getting excited about Rose-Hip Vital™ with GOPO®
CHANNEL TEN NEWS MARCH 2010
RECENT MEDIA COVERAGEEveryone’s getting excited about Rose-Hip Vital™ with GOPO®
ADVISORY HOTLINE
1800 851 888www.rosehipvital.com.au
AUST L 91041
2010 © Rose-Hip Vital Australia Pty LtdIf symptoms persists consult your healthcare practitioner.
Always read the Label. Use only as directed.
