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Thursday, January 19, 2012
SUPERFICIAL MYCOSES
Thursday, January 19, 2012
WHAT ARE SUPERFICIAL MYCOSES?
Superficial mycoses are cosmetic fungal infections of the skin or shaft
No living tissue is invaded
No cellular response from the host
No pathological changes elicited
These infections are often so innocuous that patients are often unaware of their condition.
Thursday, January 19, 2012
TINEA VERSICOLOR (Pityriasis versicolor)
Malassezia furfur: commonly known as “an-an”
Direct microscopic examination of alkali stain (KOH or PAS) treated with skin scrapings: “spaghetti and meatballs”
CONFIRMATION: cultures are not routinely done
ORGANISMS: lipophilic = requires fatty acid-supplemented http://missinglink.ucsf.edu
Thursday, January 19, 2012
TINEA VERSICOLOR (Pityriasis versicolor)
Lesions occur most frequently on the upper torso, arms, and abdomen as discrete hyper – or hypopigmented macular lesions.
They scale very easily, giving the affected area a dry, or chalky appearance.
Sometimes, lesions appeared to be elevated and folliculitis may occur if hair follicles were involved.
http://dermimages.med.jhmi.edu
Thursday, January 19, 2012
TREATMENT
1% selenium sulfide applied every other day for 15 minutes and then washed off
Thursday, January 19, 2012
TINEA NIGRA(Exophiala werneckii)
usually asymptomatic and consist of well demarcated macular lesions (discolored spots on the skin that are not raised above the surface) that enlarge by peripheral extension
brown to black lesions = often seen at the sole of the foot or at the palmar surface of the hand (other body areas may also be affected)
Thursday, January 19, 2012
TINEA NIGRA(Exophiala werneckii)
Diagnosis: darkly pigmented yeast like cells and hyphal fragments in microscopic examination of KOH tested scrapings taken from affected area
confirmatory test is made by culture
Thursday, January 19, 2012
TREATMENTundecyclenic acid
keratolytic agent
Whitfield’s ointment (daily)
Tincture of iodine, 2% salicylic acid or 3% sulfur
Thursday, January 19, 2012
WHITE PIEDRA(Trichosporon beigelii)
soft, white to light brown nodules
form on axillary, pubic, beard and scalp hair
relapse common
Thursday, January 19, 2012
WHITE PIEDRA(Trichosporon beigelii)
hyaline septate hyphae that fragment into oval or rectangular arthroconida
blastospores can also occur at one or more points on the arthrospores
Thursday, January 19, 2012
TREATMENT & DIAGNOSIS
DIAGNOSIS
direct microscopic exam of hairs
culture: asexual phase of the fungus
TREATMENT
shaving or cutting the infected hair
Topical fungicides: bichloride of mercury (1:200)
Benzoic and salicylic acid combinations
3% sulfur ointments
Thursday, January 19, 2012
BLACK PIEDRA(Piedraia hortae)
hard black nodules formed around the scalp hair (carbonaceous; can house an asci)
thick-walled closely septate hyphe, with chlamydoconidia
growth is dimorphic – hyphae arthroconidia, and blastoconidia.
Thursday, January 19, 2012
DIAGNOSIS & TREATMENT
DIAGNOSIS:
direct microscopic examination of affected hair
culture: Saborauds dextrose agar
TREATMENT
therapy: shaving and cutting the infected hair
topical fungicides, bichloride of mercury
Benzoic acid/salicylic acid combinations
Thursday, January 19, 2012
BLACK VERSUS WHITE
CHARACTERISTIC BLACK PIEDRA WHITE PIEDRA
Etiology Piedraia hortae Trichosporon beigelii
Nodules
Over and around the hair shaft , hard, difficult to detach from the hair
On the surface of the hair shaft, softer, easy to separate from hair
Direct ExaminationsTightly packed dichotomous branched hyphae
Arthrospores and blastopores can be seen
Presence of asci Positive Negative
Thursday, January 19, 2012
CUTANEOUS MYCOSES
Thursday, January 19, 2012
CUTANEOUS MYCOSES : DERMATOPHYTESsuperficial fungal infections of the skin, hair and nails
may stimulate immune response
no living tissues are involved = generally restricted to the keratinized layers of the integument and its appendages
NOTE: a variety of pathological changes may occur in the host because of the presence of infectious agent and its metabolic product
Thursday, January 19, 2012
CLASSIFICATION OF DERMATOPHYTES
Thursday, January 19, 2012
REPRESENTATIVE DERMATOPHYTES
Thursday, January 19, 2012
CLINICAL FEATURES OF DERMATOPHYTE INFECTIONS
SKIN DISEASE LOCATION OF LESIONS CLINICAL APPEARANCE
FUNGI MOST FREQUENTLY RESPONSIBLE
TINEA CORPORIS(ringworm) Non-hairy smooth skin
clinical patches with advancing red,
vesiculated border and central scaling =
pruritic
Microsporum canis, Trichophyton
mentagrophytes
TINEA PEDIS (athlete’s foot)
interdigital spaces on feet of persons wearing
shoes
acute: itching, red vesicular
chronic: itching, scaling, fissures
T. rubrumT. mentagrophytesEpidermophyton
floccosum
TINEA CRURIS (jock itch) groin
erythematousnscaling lesion in intertriginous
areas = pruritic
T. rubrumT. mentagrophytes
E. floccosum
Thursday, January 19, 2012
CLINICAL FEATURES OF DERMATOPHYTE INFECTIONS
SKIN DISEASE LOCATION OF LESIONS CLINICAL APPEARANCE FUNGI MOST FREQUENTLY RESPONSIBLE
TINEA CAPITIS
scalp hair
ENDOTHRIX: fungus inside hair shaft
EXOTHRIX: fungus on surface of hair
circular bald patches with short hair stubs or broken hair within hair follicles = Mircosporum-infected hair fluoresce
M. canisT. tonsurans
TINEA BARBAE beard hair edematous, erythematous lesion
T. rubrumT. mentagrophytes
TINEA UNGUIUM (onychomycosis) nail
nails thickened or crumbling distally, discolored = usally
associated with Tinea pedis
T. rubrumT. mentagrophytes
E. floccosum
Thursday, January 19, 2012
TINEA CAPITIS (ringworm of the scalp)
Thursday, January 19, 2012
TINEA BARBAE
Thursday, January 19, 2012
TINEA CORPORIS(ringworm)
Thursday, January 19, 2012
TINEA CRURIS (jock itch)
Thursday, January 19, 2012
TINEA PEDIS (athlete’s foot))
Thursday, January 19, 2012
TINEA MANUUM
Thursday, January 19, 2012
TINEA UNGUIUM (onychomycosis)
Thursday, January 19, 2012
Microsporum audoinii
Tinea capitis = intercalary chlamydoconidium
Thursday, January 19, 2012
Microsporum canis
Tinea capitis, corporis and barbae = pyriform shaped conidia
Thursday, January 19, 2012
Microsporum cookei
saprophytic = may be found in animal hairs (dogs and rodents)
Thursday, January 19, 2012
Microsporum ferrugineum
Tinea capitis, corporis = bamboo-shaped hyphae
Thursday, January 19, 2012
Microsporum gypseum
Tinea capitis, corporis, favosa = ellipsoidal; 4-6 cells in macroconidia
Thursday, January 19, 2012
Microsporum gallinae
white comb lesion in chicken = blunt tip; cylindrofusiform-shaped
Thursday, January 19, 2012
Microsporum nanum
Tinea capitis, corporis = ringworm of pigs
Thursday, January 19, 2012
Epidermophyton floccosum
Tinea cruris, pedis, unguium = rarely invades hair
Thursday, January 19, 2012
Microsporum equinum
Tinea in horses = large chain of spores
Thursday, January 19, 2012
Microsporum fulvum
Tinea capitis = bullet-shaped septa
Thursday, January 19, 2012
Trichophyton mentagrophytes
all types of tinea = spiral hyphae “en grappe”
Thursday, January 19, 2012
Trichophyton rubrum
all types of tinea = “en thyrse”
Thursday, January 19, 2012
Trichophyton veruccosum
Tinea corporis, barbae = ringworm in cattle (culture requires inositol)
Thursday, January 19, 2012
Trichophyton tonsurans
Tinea capitis, corporis - originates from aborigines
Thursday, January 19, 2012
Trichophyton schoenleinii
Tinea capitis, favosa, corporisfavus = scutula (permanent hair loss)
Thursday, January 19, 2012
Trichophyton violaceum
Tinea capitis, favosa, corporis = black dot (deep violet in culture)
Thursday, January 19, 2012
Trichophyton concentricum
Tinea imbricata = resembles antler tip
Thursday, January 19, 2012
ECOLOGICAL NICHE OF CUTANEOUS MYCOSES
Thursday, January 19, 2012
COMPARING HAIR INFECTIONS
Thursday, January 19, 2012