SCOTT WAGERS, MD

Multi-stakeholder collaborations in the life sciences that deliver.

Helping make your ideas for step changes concrete.

A guidebook for building your confidence and your career as a researcher - steps.

The researchers need pyramid is a structure that can help you to think about how to build your capacity as a researcher. You can read more here: http://www.horizon2020consulting.com/mastering-the-researcher-needs-pyramid/

Step 1: Find an accountability partner(s) and plan regular meetings.

Step 1: Answer the question: What step change do I want to contribute to ?

Step 3: Write the introduction to the hypothetical manuscript where you contribute the most to the step change.

Why is this research important?What did you do?How will it have an impact?

A good introduction answers these three questions succinctly and clearly.

Step 3: Frame your next grant funding proposal.

1. Most drugs are effective in limited number of patients.

2. Knowing which drugs to use for which patients is challenging.

3. Goal to provide more effective interventions tailored to common molecular phenotypes has not been met because of individual variation in response.

© BioSci Consulting www.biosciconsulting.com

1. Deliver novel concepts for disease-mechanism based patient stratification.

2. Integrate multi-dimensional & longitudinal data to harness the power of omics including:• Pharmacogenetics• Systems biomedicine• Network analysis• Computational modelling

3. Focus on complex diseases with high socioeconomic impact

Budget: 4- 6 million

• New models for patient stratification to inform clinical decision making.• Accelerate the translation of biomedical and clinical research results to medical use.• Increased cost-effectiveness of the novel concepts compared established practices.• Increased research and innovation opportunities in particularly small or medium-sized enterprises (SMEs).

http://onlinelibrary.wiley.com/doi/10.1038/msb4100095/full

1. Pre-clinical & clinical studies

2. Regulatory aspect of clinical practice

3. Consideration of commercial opportunities

4. Patient associations

Any type of grant funding application can be framed in a simple way that helps you to plan and create opportunities. This frame has text from a H2020 call topic on patient stratification. Filling this in is a practical guide to your next funding proposal and a strategic guide for building your own capacity.

Step 4: Plan your strategy and tactics on a regular basis.

“Most of us spend too much time on what is urgent and not enough time on what is important.”

― Stephen R. Covey

This planning sheet helps you to focus on your needs as a researcher and proactive capacity building or ‘axe sharpening’

Building confidence is about building knowledge and expertise so that you know what to do and when to do it.