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SQUAMOUS CELL CARCINOMA
Typical Practice in Rural African Setup
Dr. Anton VurdaftApril 2015
Squamous Cell Carcinoma of Conjunctiva: Definition
Squamous cell carcinoma is a cancer That means it is a malignant tumor It is non-melanocytic It is epithelial It can be on the surface only (non-invasive) It can be invasive to the eyeball and
adnexa
(1)
Risk Factors for SCC
• Living closer to equator (exposure to sunlight)
• More advanced stages and more common in men
• Human papillomavirus type 16 (HPV 16)• HIV (AIDS)
(9)
Squamous Cell Carcinoma: Localization
Eyelids Conjunctiva Cornea Orbit
(1)
Squamous Cell Carcinoma of the Eyelid
5-10% of all eyelid malignancies (second after basal cell carcinoma in western countries)
(1)
Squamous Cell Carcinoma of the Eyelid
(1)
Squamous Cell Carcinoma of the Eyelid
Actinic keratosis is often a precursor of SCC
Squamous Cell Carcinoma of the Eyelid: Pathology
(1) Surface ulceration
(2) Keratin pearls in large nests of squamous epithelium
(3) Isolated nests of malignant cells invading dermis
Squamous Cell Carcinoma of the Eyelid
(1)
Biopsy and histopathology are required most of the times prior to surgical treatment
Invasion of the dermis is the hallmark for the histopathologic diagnosis of invasive SCC
Orbital invasion may be diagnosed with imaging investigations
Squamous Cell Carcinoma of the Eyelid: Prognosis
Risk of metastatic dissemination is 1-21% Eyelid SCC is potentially fatal and
responsible for considerable morbidity Orbital invasion is a rare complication
that has been reported to occur in 2.5 %
(2)
Non-Invasive SCC of the conjunctiva
(3)
Invasive SCC of the Conjunctiva
Invasive conjunctival SCC (Pathology)
(1) – Carcinoma in situ and displasia(2) – Invasive nests of cancer cells
Squamous Cell Carcinoma of the Conjunctiva
Risk of metastatic dissemination is very low (0,5-3%)
Grading of Epithelial Precancerous and Cancerous Lesions of the
Conjunctiva and Cornea
Squamous cell carcinoma is not the only possible diagnosis for the lesion like this
(4)
Grading of Epithelial Precancerous and Cancerous Lesions of the
Conjunctiva and Cornea
Currently the proper diagnosis for any precancerous or cancerous epithelial lesion of the conjunctiva and cornea
before getting the results of histopathology
is OSSN(Ocular Surface
Squamous Neoplasia) (5)
OSSN Definition
Ocular Surface Squamous Neoplasia is any epithelial precancerous or cancerous lesion of the conjunctiva and cornea. This is the only diagnosis we can make without
histopathology.
(6)
(7)
OSSN
OSSN Grading
OSSN can be graded into: • Dysplasia
• Carcinoma in situ (CIS)• Squamous cell carcinoma (SCC)
(8)
Frequency of OSSN
• 0,3 per million in USA• 19 per million in Australia
• Much more common in countries with bigger HIV prevalence
(10)
Clinical SignsIt is difficult to differentiate
between conjunctival epithelial dysplasia, carcinoma in situ and
squamous cell carcinoma clinically
(11)
AIDS and OSSNHIV (AIDS) epidemics caused increased incidence of OSSN
Check CD4 in each patient with presumed OSSN
(12)
Differential Diagnosis of OSSN
Pingueculas, Pterygia, Squamous Papillomas
(13)
Pterygium and OSSN
(14)
Workup
(15)
Different types of cytology or incisional / excisional biopsy are needed to make proper
diagnosis
Workup
(16)
Check for most frequent metastases: preauricular, submandibular, cervical
lymph nodes, parotid gland, lungs, bones
Treatment of OSSN
(17)
1st: initiation of HAART if appropriate (even invasive SCC may resolve)
2nd: excision with safety margins (4 mm)
3rd: antimetabolites4th: frequent reviews for recurrences
OSSN and Recurrences
(18)
Treatment of SCC
(19)
1st: wide excision if possible2nd: eye amputation
3rd: radiotherapy4th: frequent reviews for
recurrences
Eye Amputations
(20)
• Evisceration• Enucleation•Exenteration
Enucleation
Enucleation
Exenteration
(21)
Exenteration: self-granulating wound
Exenteration: orbital invasive SCC
Exenteration: orbital invasive SCC
Exenteration: conjunctival SCC
Prognosis in Invasive Tumors
Invasion: conjunctival, scleral, corneal. Longstanding cases: invasion into the eye and orbit.Metastases: regional lymph nodes (relatively uncommon.Death from metastatic disease is rare (1-2%)
Take Home Messages
(22)
• Do not forget to check regional lymph nodes in patients with tumors
• Motivate patients with OSSN for early treatment
• Avoid excision without antimetabolites• Review patients post excision frequently• Check for HIV/CD4 in all OSSN patients• Do send for histopathology
Thank you