Snapshot of investigational anti-Ebola therapiesZEENA NACKERDIEN

Potential anti-Ebola drugs Pre-clinical antivirals References

oral T-705 (Favipiravir) Smither et al, 2014

griffithsin (antiviral lectin) Barton et al, 2014

benzodiazepine derivative (compound 7) Basu et al, 2014S-adenosyl-L-homocysteine hydrolase inhibitor Bray et al, 2000; Huggins et al, 19993-deazaneplanocin A Bray et al, 2002Small molecule inhibitors of ER alpha-glucosidases Chang et al, 2013FGI-103, FGI-104, FGI-106, dUY11, and LJ-001 de Clerq et al, 2013novel broad-spectrum small molecule that could block cathepsin L-mediated cleavage Elshabrawy et al, 2014ribavirin Huggins et al, 1989a set of selective estrogen receptor modulators (SERMs), including clomiphene and toremifene, which act as potent inhibitors of EBOV infection Johansen et al, 2013Retinazone Kesel et al, 2014C795-0925, D011-2120, F694-1532 and G202-0362 Mudhasani et al, 2014BCX4430 Warren et al, 2014

lamivudine (anecdotal)A Liberian doctor is using HIV drugs to treat Ebola victims. The NIH is intrigued.

Investigational Ebola vaccines

Latest updates on Ebola vaccine trials (clinicaltrials.gov)

NCT00072605 , VRC-EBODNA012-00-VP

NCT00374309 ,VRC-EBOADV018-00-VP

NCT00605514 ,VRC-EBODNA023-00-VP|VRC-MARDNA025-00-VP

NCT01353027 ,Placebo|AVI-6002

NCT00997607 ,Ebola vaccine| Marburg vaccine|Placebo injection

NCT02240875 , cAd3-EBO Z at 1 x 10^10 vp|cAd3-EBO Z at 2.5 x 10^10 vp| cAd3-EBO Z at 5 x 10^10 vp

NCT02267109 ,Ebola Chimpanzee Adenovirus Vector Vaccine (cAd3-EBO Z)

NCT02269423 ,BPSC-1001| Placebo

NCT00646152 , Poly-ICLC

NCT02231866 ,VRC-EBOADC069-00-VP

NCT02271347 ,CMX001

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