CASE REPORT: SMALL-CELL CARCINOMA OF THE BLADDER *K.C.SKOSANA ,MBCHB; ** T.KEKANA ,MBCHB,Mmed Anat.Pathology.

INTRODUCTION

Primary neuroendocrine carcinomas of the urinary bladder are rare. Small-cell carcinoma of the urinary bladder (SCCUB) accounts for less than 1% of all cancers arising in the urinary bladder.Here, we report a case of a 40-year-old woman who presented with a bladder tumour.In this report, the clinical, histological, and immunohistochemical features of this case are described.

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RESULTS: The histological features and immunohistochemical profile of this tumour are those of a small-cell neuroendocrine carcinoma of the bladder.

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RESULTS

Synaptophysin

Chromogrannin Figure 1.H & E

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Figure 2.H & E Vimentin

Department of Anatomical Pathology, University of Limpopo-MEDUNSA CAMPUS

OBJECTIVE : A 40 year female patient presented with a bladder tumour. A transurethral resection of the tumour was performed and the specimen was sent for histopathology assessment.

METHODS:

GROSS - The specimen consists of four brownish and whitish tissue fragments, the largest measuring 20mm x 10mm x 10mm.MICROSCOPIC FINDINGS - The H & E sections show a bladder mucosa infiltrated by

a malignant tumour arranged in nests and diffuse growth pattern. The tumour cells are pleomorphic, have a round, oval to polygonal shape and a scanty cytoplasm. Muscularis propria and perineural invasion are present.The tumour cells are small to medium in

size. The nuclei are hyperchromatic and some are vesicular with an even fine to coarse

chromatin distribution. There are no prominent nucleoli. No mitoses are present. See figures 1 & 2

IMMUNOHISTOCHEMISTRY: SYNAPTOPHYSIN - POSITIVE CHROMOGRANNIN - POSITIVE CYTOKERATIN - NEGATIVE VIMENTIN - NEGATIVE .

Cytokeratin (34BE12)

CONCLUSION: This is a case of rare small-cell carcinoma of the bladder and the first ever reported in this institution.