SATT Sud Est e-Health booklet

e-HEALTH TECHNOLOGIES Partnering & licensing opportunities in the fields of medical imaging software, medical device & data processing, and telehealth

February 2014

INNOVATE RISK-FREE AND ECONOMICALLY BY EXPLOITING PUBLIC RESEARCH RESULTS OF SOUTH EASTERN FRANCE

www.sattse-technologies.com

e-Health Technologies booklet - Feb. 2014 I page 2

5 MEDICAL IMAGING SOFTWARE10 MEDICAL DEVICE AND DATA PROCESSING13 TELEHEALTH

CONTENTS

Please email all inquiries to [email protected]

LICENSING & START-UP CREATION DEPARTMENT

CONTACT US

R&D MANAGERS, ENTREPRENEURS, ACCELERATE YOUR GROWTH BY EXPLOITING THE RESULTS OF PUBLIC RESEARCH. LEARN ABOUT OUR INNOVATIVE TECHNOLOGIES, PRODUCED BY SOUTH EASTERN FRANCE PUBLIC RESEARCH. THESE TECHNOLOGIES ARE AVAILABLE FOR LICENSING AND/OR R&D PARTNERING (WITH POTENTIAL CO-FINANCING).

page 3

About SATT Sud EstHeadquartered Marseille, FRANCE

HELPING COMPANIES TO BOOST THEIR COMPETITIVENESS THROUGH INNOVATION STEMMING FROM PUBLIC RESEARCH OF SOUTH EASTERN FRANCE

The core business of SATT Sud Est (South East, in English), Accelerator of Technology Transfer, involves ensuring legal (intellectual property), economic (market) and technological (proof of concept) maturation of inventions developed by regional research laboratories.

SATT Sud Est is focused on bridging the technology gap between the development of technologies resulting from public research and their industrial-scale production. Its objective is to transfer innovative technologies belonging to its shareholders over into the socio-economic world via licensing agreements with companies.

SATT Sud Est WAS ONE OF THE FIRST ACCELERATORS OF TECHNOLOGY TRANSFER AMONG THE 14 THAT WERE CREATED UNDER THE FRENCH “INVESTMENTS FOR THE FUTURE” PROGRAM – WWW.SATT.FR

STRENGTHENED BY THE EXCELLENCE in regional research, together with the skills and expertise of its business teams specialized in technology transfer and licensing & start-up creation, SATT is a key player in regional economic development associated with innovation.

Olivier FRÉNEAUXPresident

SATT Sud Est TECHNOLOGY TRANSFER PROCESS INVENTION MATURATION (TECHNOLOGY OR EXPERTISE)

INVENTION DISCLOSURE

LEGAL (INTELLECTUAL PROPERTY)

LICENSES (EXISTING COMPAGNIES, START-UP)

ECONOMIC (MARKET)TECHNOLOGICAL (PROOF OF CONCEPT)

LEARN ABOUT OUR INNOVATIVE TECHNOLOGIES AND KNOW-HOW ONLINE AT WWW.SATTSE-TECHNOLOGIES.COM AND MAKE YOUR OFFER MORE COMPETITIVE WHILE BOOSTING YOUR GROWTH

ICARE IMMUNOFLUORESCENCE FOR COMPUTED ANTINUCLEAR ANTIBODIES

RATIONAL EVALUATION

© copyright 2012 SATT PACA Corse SAS. All rights reserved.

SATT PACA Corse SAS with a capital of €1 million | RCS Marseille 539 768 085 00018 | APE 7219Z | last update Sept. 2013

BENEFITS

SMART SOFTWARE

HELP FOR THE

ACCREDITATION PROCESS

COST EFFECTIVE

TIME-SAVING

HIGH DISCRIMINATING

LEVEL

TRACEABILITY

KEYWORDS

AUTOIMMUNE DISEASE

DIAGNOSTIC

ANTINUCLEAR ANTIBODIES

AUTOMATED READING

STANDARDIZATION

IP

PATENT

EP 13305578.0 (May 2013)

PARTNERSHIPS

LICENSE AND/OR

R&D COLLABORATION (POSSIBLE CO-FUNDING)

CONTACT

Claire NAUSSAC MSc

Health & Life Technologies

Business Development Manager

Cell +33 (0)6 03 17 65 05

[email protected]

www.sattse.com

BACKGROUND • Indirect immunofluorescence (IF) assay on HEp2 cells is the gold standard for

antinuclear antibodies (ANA) determination, essential markers for the diagnostic

of connective tissue diseases. However this method is time-consuming, operator-

dependent, and lacks of reproducibility as well as standardization.

• Automated reading of IF provides solutions to maximize efficiency, reduces

reading-subjectivity, attenuates intra- and inter-laboratory variabilities and

opens the access of standardization.

APPLICATIONS

Accreditation process / Full automation / Autoimmune exploration

KEY BENEFITS vs. STATE OF THE ART

• ICARE is the only system that is compatible with all manufacturer’s slides

• ICARE is validated and shows high performances even for weak positive samples

ABOUT OUR TECHNOLOGY

• This new technology has been developed by a multidisciplinary team biologists in

medical laboratory of immunology, experts in fundamental immunology and

image analysis with both academic and clinical skills.

• Original algorithm based on the acquisition of a double fluorescence signal and

the obtaining of a fluorescence index. The automated reading is a two steps

process:

1. Quantitative screening of positive and negative

samples with high discriminating level

2. Aspect identification

5

CELL ID STATISTICAL ANALYSIS OF HIGH CONTENT CELLULAR

AND TISSULAR IMAGES

BENEFITS

REAL-TIME INTERACTIVE

SEGMENTATION

ACCURATE STATISTICS

POTENT & ACCURATE

CLASSIFICATION

USER-FRIENDLY TUNING

BIG DATA CAPABILITY

IP

PATENT

BACKGROUND

CELL ID is a unique software solution for high content cellular imaging. It enables

accurate statistical analysis on large scale cells or biological tissues databases.

Off-the-shelf HCS platforms and automated microscopes daily capture and store

thousands of pictures. However, downstream, cell classification is mostly done by

human eye and brain (expert biologists) – a time-consuming and poorly

reproducible task.

Developed by experts in classification algorithms in close cooperation with

biologists, CELL ID overcomes such limitations, offering the practitioner an

automated supervised classification. The solution operates in three steps:

APPLICATIONS

Cell and tissue analysis for research or

diagnosis in:

• Anatomopathology

• Toxicology

• Oncology

© copyright 2012 SATT PACA Corse SAS. All rights reserved. © iStockphoto.com


KEYWORDS

SEGMENTATION

QUANTITATIVE

ANALYSIS

STATISTICAL ANALYSIS

MACHINE LEARNING

SUPERVISED

CLASSIFICATION

DEVELOPMENT

STATUS

• C++ Software

• High content cell dataset

• Currently validated by

physicians

KEY BENEFITS vs. EXISTING

Few solutions are available today. On the one hand, one finds basic classifiers

with limited settings and/or providing poorly reliable results. On the other hand,

stands a powerful but highly complex tool.

CELL ID differentiates through:

• Automated/tunable algorithmic parameters

• Real-time segmentation

• Supervised classification with ROC curves

• Included database of statistical features

• User-friendly human interface

1. Interactive

segmentation

2. Statistical

analysis

3. Supervised

classification

class A

class B

PARTNERSHIPS

LICENSE AND/OR


CONTACT

Laurence LACROIX-ORIO Ph.D.

Chemistry & e-Health


Cell +33 (0)7 77 08 59 45

[email protected]

www.sattse.com

6

PARTNERSHIPS

LICENSE AND/OR


VOXELSHIFT MORE RELIABLE CHEMICAL SHIFT IMAGING

BENEFITS

GRID FREE

ADJUSTABLE VOXEL

POSITIONING

TUNABLE VOXEL SIZE

AND SHAPE

ENHANCED

DISCRIMINATIVE

METABOLITE MAPS

IP

PATENT

BACKGROUND

The CRMBM team (Center for Biological and Medical Magnetic Resonance) - part of

CNRS / Aix-Marseille Université - has over 20-year experience in MRI and spectral

MR for medical research and diagnosis purposes.

As for CSI, they have developed a robust solution, already used in several research

centers.

APPLICATIONS

In vivo real time observation of metabolites concentration

Brain, prostate, kidney … cancer diagnosis


SATT PACA Corse SAS with a capital of €1 million | RCS Marseille 539 768 085 00018 | APE 7219Z | last update Dec. 2012

KEYWORDS

MR MAGNETIC

RESONANCE

CSI CHEMICAL SHIFT

IMAGING

SPECTROSCOPY

METABOLITES

MAPPING

REAL-TIME VOXEL

SHIFT

DEVELOPMENT STATUS

VOXELSHIFT significantly increases the

accuracy of voxel, translating into

enhanced diagnosis capabilities for

practitioners.

Their CSIAPO software allows the user to

define the voxel size, shape position

(independently from the grid) and access

in real time to the voxel MR spectrum.

CONTACT




Cell +33 (0)7 77 08 59 45

[email protected]

www.sattse.com

7

KEY BENEFITS vs. STATE OF THE ART Stimulated Raman Scattering (SRS) microscopy is a new technology which allows imaging – without labeling or staining - of specific molecular bonds of chemical species present in cells and tissues. SRS is usually considered as an artifact free technique which is an important feature in its favor.

The charts below (experiment on human tissue) clearly demonstrate that SRS exhibits artifacts in the amide (C=O and N-H bonds) and fingerprint regions. This is a major issue when imaging through scattering medium as tissues.

SRGOLD is an artifact free SRS technique based on off-the-shelf equipment that provides:

Artifact free imaging of molecular bonds of chemical species present in cells and tissues in the whole spectra from the fingerprint to the lipid-protein regions.

Enhancement (x2) of signal intensity.

Enhancement of molecular contrast in scattering medium

SR-GOLD ARTIFACT FREE STIMULATED RAMAN SCATTERING:

STIMULATED RAMAN GAIN OPPOSITE LOSS DETECTION

BENEFITS

IMAGING IN AMIDE

AND FINGERPRINT

REGIONS

EFFICIENT IN

SCATTERING SAMPLES

TWO-FOLD SIGNAL

INCREASE

EASY TO IMPLEMENT

KEYWORDS

SRS

MOLECULAR IMAGING

IN CELLS AND TISSUE

LABEL AND STAIN

FREE MICROSCOPY

IP

PATENT

BACKGROUND

Within the scope of the development of instruments dedicated to the

understanding of molecular interaction in the cell machinery and tissue

organization, the Fresnel Institute, a French academic laboratory, has developed

a Stimulated Raman Scattering instrument with improved sensitivity and contrast

allowing imaging from the fingerprint region to the lipid-protein region without

artifacts inherent to this technology.

SRS spectra (red) on human skin are not artifact free in amide and fingerprint regions

APPLICATIONS

• Label and stain free imaging

of tissues and cells

• Vibrational spectroscopy

• Molecular imaging

Development Status

• First microscope prototype

characterized

• Proof of concept on polystyrene

beads and human tissues


SATT PACA Corse SAS with a capital of €1 million | RCS Marseille 539 768 085 00018 | APE 7219Z | last update Mar. 2013

PARTNERSHIPS

LICENSE AND/OR


CONTACT




Cell +33 (0)7 77 08 59 45

[email protected]

www.sattse.com

8

PARTNERSHIPS

LICENSE AND/OR


SIMILAR IMAGING

ESTIMATING THE SIMILARITY BETWEEN IMAGES OF

DIFFERENT MODALITIES

BENEFITS

PATTERN MATCHING

IMAGE REGISTRATION

IMAGE SEGMENTATION

IMAGE ALIGNMENT

KEYWORDS

IMAGE & COMPUTER

VISION

IMAGE REGISTRATION

REMOTE SENSING

MULTIMODALITY

BACKGROUND

Nowadays, discovering the correspondence relationships among images captured

by various sensors corresponding to different modalities is a major issue.

Similar Imaging can estimate the correct alignments related to collections of

images captured by various sensors corresponding to different modalities (radar,

optical, etc…).

Spatial information by means of 2D clouds of points is extracted from each image

and a matching process is performed taking into account the remote sensing

context.

Considering which parts of the images are strongly related, the matching process

is refined in order to get a more robust and accurate way to perform the global

registration.

KEY BENEFITS vs STATE OF THE ART

• Applies to any pair of modalities without knowledge of these modalities

• Takes into account the specificity of the remote sensing context

• Gives a score that estimates the similarity of 2 regions

• Can detect false alarms during results compiling

• Performs a robust and accurate approach

APPLICATIONS

• Satellite/aerial images analysis

• Remote sensing

• Computer vision for robotics

• Medical imaging

Development status

Basic prototype supporting all

classical image file formats


SATT PACA Corse SAS with a capital of €1 million | RCS Marseille 539 768 085 00018 | APE 7219Z | last update May 2013

Multi-spectral image Radar image

True alarm

False alarm

IP

PATENT

CONTACT


Chemistry & e-Health Business

Development Manager

Cell +33 (0)7 77 08 59 45

[email protected]

www.sattse.com

9

PARTNERSHIPS

LICENSE AND/OR


SLEEP APNEA CONTACTLESS DEVICE DIAGNOSIS/MONITORING WITHOUT INVASIVE NASAL CANNULA

BENEFITS

NON INVASIVE DEVICE

PATIENT FREE TO MOVE

ADAPTABLE AT HOME

ORAL AND NASAL

RESPIRATORY FLOWS

COMPATIBLE WITH STD

DATA ACQUISITION UNITS

IP

PATENT

COPYRIGHT

BACKGROUND

Available methods for the diagnosis of obstructive sleep apnea/hyponea require

multiple sensors to be placed on the patients’ face, particularly an invasive nasal

cannula, therefore disturb the patients’ sleep and alter the diagnosis.

To circumvent these issues, we offer a simple and contactless diagnosis-

monitoring method and device that are based on sensors of both the oral and

nasal respiratory flows and do not hamper the patients moves during sleep.

APPLICATIONS

Diagnosis of obstructive sleep apnea and hypopnea (adults

and children)

KEYWORDS

SLEEP APNEA

SLEEP HYPOPNEA

CONTACTLESS DEVICE

RESPIRATORY MONITORING

• Transportable prototype

• Tested under real-life

conditions

• Available for demos



SATT PACA Corse SAS with a capital of €1 million | RCS Marseille 539 768 085 00018 | APE 7219Z | last update Jan. 2014

As for Practitioners …increased reliability and flexibility

Both nasal and oral respiratory flows detected

No more sensor removal by patients (esp. children)

Simple method

As for Patients …highly improved comfort and better sleep

No more invasive devices on skin face

Ease of use at home

Freedom to move head

sensors

DEVELOPMENT STATUS

CONTACT




Cell +33 (0)7 77 08 59 45

[email protected]

www.sattse.com

10

PARTNERSHIPS

LICENSE AND/OR


PROP SCORE ACCURATE AND RELIABLE ASSESSMENT OF JOINT PROPRIOCEPTIVE

STATUS

BENEFITS

ACCURATE, RELIABLE

AND REPRODUCIBLE

MEASURES

RELIABLE SCORE

INTERPRETATIVE REPORT

IP

PATENT

BACKGROUND

Acting as an actual sixth sense, proprioception is the perception of the position

(statesthesia: postural sensitivity) and movement (kinesthesia: movement

sensitivity) of segments in space without visual information. Proprioceptive

impairment affects functional joint stability, therefore the risk of injury.

APPLICATIONS

• Medical/paramedical: rehabilitation and

prevention programs, pre/post medical

intervention, post-traumatic

• Sport/fitness: optimization of training

KEYWORDS

PROPRIOCEPTION

STATESTHESIA

KINESTHESIA

JOINT

ERGOMETER

REHABILITATION

TRAINING DEVELOPMENT

STATUS

• Demonstrator available

• Qualified by a professional

soccer club that developed

prevention programs and

proprioceptive training

during several seasons

• Normative database available


PROP SCORE is a polyarticulated ergometer

driven by an acquisition and treatment

software, which delivers the proprioceptive

status of a joint (upper or lower limbs).

An algorithm combines statesthesia and

kinesthesia, and delivers the proprioceptive

"score" of the patient.

A report is formalized according to gender,

age, sport practice, medical history of the

patient and following normative or its own

data.


SATT PACA Corse SAS with a capital of €1 million | RCS Marseille 539 768 085 00018 | APE 7219Z | last update Jan. 2014

Computerized measuring bench

PERSONAL DATABASE

NORMATIVE DATABASE

Proprioceptive evaluation of a joint

Customized report

Existing

methods

Proprioceptive assessment is

subjective and non reliable

PROP

SCORE

Easily provides a proprioceptive

SCORE that is:

Objective and interpreted

with regards to a

normative database

Quantified

Reproducible

Reliable

• Health psychology (e.g. seniors fall prevention)

CONTACT




Cell +33 (0)7 77 08 59 45

[email protected]

www.sattse.com

11

PARTNERSHIPS

LICENSE

MAMMOSCAN ONE-SHOT LOCALIZATION OF 3D TARGETS IN PHOTOACOUSTIC/

THERMOACOUSTIC IMAGING

BENEFITS

ONE-SHOT

FAST TARGET

LOCALIZATION

ACCURATE

MEASUREMENT

SIMPLE PROCESSING

BREAST CANCER EARLY

DETECTION

IP

PATENT

BACKGROUND

PhotoAcoustic/ThermoAcoustic computed Tomography (PAT/TAT) is an emerging

technique that promises cancer screening without ionizing radiation.

APPLICATIONS

• Medical imaging, e.g.breast cancer, angiology, dermatology

• Materials characterization, e.g. geology

© copyright 2012 SATT PACA Corse SAS. All rights reserved. © spie.org


KEYWORDS

PHOTOACOUSTIC

THERMOACOUSTIC

TOMOGRAPHY

PAT / TAT

BREAST CANCER

DETECTION

TUMOR LOCALIZATION

TISSUE

CHARACTERIZATION

DEVELOPMENT STATUS

Simulation model validated


MAMMOSCAN definitely improves PAT/TAT through:

• ONE-SHOT localization of targets

• EASIER processing

enabling faster target localization and more

accurate target qualification.

ST: Source-Target distance

TD: Target-Receiver Device distance

Target

Transmitter

Source

Receiver

Device

The tissue dilation induced by pulse

laser illumination generates ultrasound

waves that are detected by

transducers. By using low scattered

microwaves for excitation, PAT/TAT

allows deep tissue imaging (several

cm) with a good optical imaging

resolution (below mm).

However, current approaches require

multiple acquisitions and downstream

complex processing to locate targets,

e.g. a tumors.

MAMMOSCAN overcomes this issue

through a smarter use of marginal

signals, cf hereafter.

CONTACT




Cell +33 (0)7 77 08 59 45

[email protected]

www.sattse.com

12

CLINICAL GUIDELINES AUTOMATIC TOOL FOR MEDICAL GUIDELINES

GENERATION

BENEFITS

FAST AND ACCURATE

DIAGNOSIS AND

PRESCRIPTION SUPPORT

DATA INTERPRETATION

GLIF MODEL

EASY ACCESS

SOFTWARE GENERATION

IP

COPYRIGHT

BACKGROUND

Available Clinical Practice Guidelines (CPG) are not extensively used due to lack

of proper integration into clinical settings, of knowledge-related information

resources, and of decision support at the point of care in a particular clinical

context.

The clinical guidelines software aims to improve the assistance provided by

classical guidelines. This tool is an online service enabling physicians to consult

computerized CPG for easier integration into the healthcare process. Tree

decision tool enables to automatically generate web application.

APPLICATIONS

• Emergency

• Health, medicine, connected health

• Education

KEYWORDS

CLINICAL DECISIONS

HEALTH

MEDICAL ASSISTANCE

ONLINE SERVICE

GRAPHICAL

CONSTRUCTION

TREE DECISION

WEB CONNECTED

DEVELOPMENT STATUS

Model validated with hospital experimentation

Beta version available

KEY BENEFITS vs. STATE OF THE ART

PARTNERSHIPS

LICENSE AND/OR


PresGuid:

example of application

for prescription and

guidelines generation.


SATT PACA Corse SAS with a capital of €1 million | RCS Marseille 539 768 085 00018 | APE 7219Z | last update Feb. 2014

CONTACT




Cell +33 (0)7 77 08 59 45

[email protected]

www.sattse.com

Clinical guidelines software Existing solutions

Graphical tree decision construction Ad hoc solutions

Automatic web application generation

from tree decision Specific applications

Context sensitive access Difficult to develop/maintain

Easy programming Black box applications

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CONTACT USLicensing & Start-Up Creation: [email protected]

To set up your account and learn about our innovative technologies, go to www.sattse-technologies.com

tel +33(0) 4 91 91 91 20fax +33(0) 4 91 31 71 [email protected]

SATT Sud Est Headquarters 8 rue Sainte Barbe13001 MarseilleFRANCE

French Riviera Branch Campus Sophi@Tech Bâtiment FORUM 930 Route des Colles I BP 145 06903 Sophia Antipolis FRANCE

For more informations visit www.sattse.com and follow Twitter @SATTse_

© copyright 2013 SATT PACA Corse SAS. All rights reserved. SATT PACA Corse SAS with a capital of €1 million I RCS Marseille 539 768 085 00018 | APE 7219Z | February 2014Printed in France by a printer certified

Health & Medicine

SATT Sud Est e-Health booklet