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RELATIONSHIP BETWEEN ERECTILE FUNCTION AND METABOLIC SYNDROME IN A COHORT OF MEN WITH LOW
TESTOSTERONE LEVELS.
Eduardo García-Cruz* ***, Marta Piqueras*. Óscar Cardeñosa**, Pilar Luque*, Antonio Alcaraz**Hospital Clínic de Barcelona
**BAYER España*** Red Española de Investigación en Salud del Hombre
Conflict of interest: this initiative was conducted with a grant for investigation from BAYER España. García-Cruz had received funding for investigation from Lilly, Pfizer, Bayer, Auxilium and Janssen and had formed part of advisory comittees for Bayer, Lilly, Janssen, Italpharmaco and Menarini.
TESTOSTERONE DEFICIENCYSYNDROME
METABOLIC SYNDROME
ERECTILE DYSFUNCTION
OBJECTIVE:to determine the relationship between erectile function and Metabolic Syndrome (MS) in a cohort of men with low testosterone (T) levels.
METHODS:a multi-centre, cross-sectional study recruited 1094 consecutive men older than 45 years old with low T levels (<12nmol/L).
MS was defined as 3 or more of the following factors: abdominal obesity ≥ 94cm, triglycerides ≥150 mg/dl, Hypertension ≥130/85 mmHg, HDL-cholesterol <40mg/dL or Fasting Glucose ≥100 mg/dl.
IIEF questionnaire was used to assess erectile function.
Multivariate analysis was carried out to determine the variables related to ED and MS. P<0,05 was considered statistically significant.
Normal Erection
Mild ED Mild to moderate
ED
Moderate ED
Severe ED0
5
10
15
20
25
30
35
0%
5%
10%
15%
20%
25%
30%
35%
40%
2.10%
8.40%
20.50%
33.50%
27.40%
8.00%
No. of MetS factors
Mean testosterone levels (95%CI) and IIEF scores according to the number of MetS components (p for linear trend p=0,006).
Met Sy No Met Sy6.2
6.3
6.4
6.5
6.6
6.7
6.8
6.9
Testosterone levels regarding Met Sy (yes/no);P<0,02.
0 (n=18) 1 (n=87) 2 (n=204) 3 (n=339) 4 (n=282) 5 (n=81)0
2
4
6
8
10
12
14
16
12.8314.18
12.7611.39
10.489.81
No. of MetS factors
Mea
n IIE
F sc
ore
No ED (n=24)
Mild ED (n=143)
Mild-to-moderate ED (n=323)
Moderate ED (n=302)
Severe ED (n=219)
0 0.5 1 1.5 2 2.5 3 3.5 4
2.54
2.48
2.94
3.09
3.41
Mean No. of MetS factors
TESTOSTERONE DEFICIENCYSYNDROME
METABOLIC SYNDROME
ERECTILE DYSFUNCTION
CONCLUSION: in a cohort of men with low T levels, erectile function and MS were related in a bidirectional manner: IIEF worsened as the number of MS raised and MS factors raised as IIEF worsened.
RELATIONSHIP BETWEEN ERECTILE FUNCTION AND METABOLIC SYNDROME IN A COHORT OF MEN WITH LOW
TESTOSTERONE LEVELS.
Eduardo García-Cruz* ***, Óscar Cardeñosa**, Pilar Luque*, Antonio Alcaraz**Hospital Clínic de Barcelona
**BAYER España*** Red Española de Investigación en Salud del Hombre
Conflict of interest: this initiative was conducted with a grant for investigation from BAYER España. García-Cruz had received funding for investigation from Lilly, Pfizer, Bayer, Auxilium and Janssen and had formed part of advisory comittees for Bayer, Lilly, Janssen, Italpharmaco and Menarini.
