PHAC/CIHRInfluenzaResearchNetwork

MélanieCourtot,BCCRC,VancouverCA

NCBO/IDOworkshopBal$more▪December9th2010

PCIRNmission

•  Canadianna$onalnetworkofkeyinfluenzavaccineresearchers.

•  Developsandtestsmethodologies/methodsrelatedtotheevalua$onofpandemicinfluenzavaccinesastheypertaintosafety,immunogenicityandeffec$veness,andprogramimplementa$onandevalua$on.

•  hJp://www.pcirn.ca/

PCIRNstructure

•  ThemeI:RapidTrials•  ThemeII:RapidImplementa$on

•  ThemeIII:VaccineCoverage

•  ThemeIV:VaccineSafety

•  ThemeV:VaccineEffec$veness

•  +supportgroups

Morethan90inves$gatorsacross30ins$tu$ons

ITsupportgroup

•  Aim:tostandardizedata(samevariables,samecoding)andtoassuretheuseofstandardvalidateddefini$ons–ifpossiblefromanontologicalresource.

•  Objec$veistoensuredataqualityandconsistencyacrossthenetwork.

Standardiza$on

•  Determinecontrolledvocabulary•  MinimumInforma$on:checklisttoiden$fygap

•  Iden$fyexis$ngontologiestermssuppor$ngthenetwork,andcontributeto/developresourcesasneeded

Ontologies

•  Areasaddressed:Demographics,Labshippingandresultsinforma$on,Vaccinedetails,Exposure,Specificity

•  Exis$ngrelevantresources:IDO(InfluenzaandVaccineOntology),OBI(OntologyforBiomedicalInves$ga$ons),OGMS(OntologyforGeneralMedicalScience)…

Neuraminidasetyping

•  FLU_0000779,“Anassaywhichaimsatdeterminingtheneuraminidasetypeofaninfluenzavirus”

assay(OBI_0000070)and(has_specified_outputsome

('measurementdatum'(IAO_0000409)and('isabout'someneuraminidase(FLU_0000753))))

InfluenzaOntology

•  Influenzaneuraminidase(FLU_0001034)is_aneuraminidase(FLU_0000753)part_ofsomeInfluenzavirion(FLU_0000751)

•  Influenzavirionis_avirion(IDO_0000508)•  Neuraminidaseis_aprotein(PRO_000000001)whichhas_func2onsomecatalyFcacFvity(GO_0003824)

•  Infersis_aenzyme(OBI_0000427)

ViralRNAextrac$on

•  viralRNAextracFon(FLU_0000829)is_aRNAextracFon(OBI_0666666)

•  has_specified_inputsomeViruses(NCBITaxon_10239)

•  has_specified_outputsomeribonucleicacids(ChEBI_33697)

•  [..]sequencingassay(OBI_0600047)[..]GenBanksubmission

VaccineOntology

•  Canadianvaccinesinforma$on– Manufacturer

– Vaccinetype(eginac$vated)– Adjuvant,preserva$ves– Poten$alallergens– Routeofadministra$on– Doseinforma$on– …

Vaxigrip

•  has_partneomycin(ChEBI_44577)and(has_rolesome'vaccineallergenrole'))

•  has_partthimerosalvaccinepreserva$ve–  'vaccineaddi$ve'and(has_rolesome'vaccinepreserva$verole')

– has_partsomethimerosal(ChEBI_9546)

•  IntramuscularinjecFon(OBI_0000934)(throughskeletalmuscleFssue(FMA_14069))

•  […]

VO–VaccineOntology

AdvantagesofusingIDO

•  Lessworkforme•  Commoninfrastructure

•  Collabora$veplalorm

•  Setofresourcesfollowingsimilarguidelinesanddevelopmentprinciples

Thankyou

•  OBI,IAO,OGMSandIDOteams

•  OBOFoundry•  PHAC/CIHRInfluenzaResearchNetwork