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Personalized Medicine: using data to tailor individual treatment plans Richard Dale, COO Optum Labs @rdale MassTLC Big Data Summit, June 2013
Richard Dale, COO, Optum Labs for MassTLC Big Data and Personalized Medicine. Copyright © Optum Labs 2013, all rights reserved. 2
Session Structure
Personalized Medicine is not what you think Undefine the term
Brainstorm around the term Expand our horizons
How many dimensions will we need? Construct a market map
Where are we heading? Sketch the trajectory
Personalized Medicine is not what you think
Tell me your definition… Write it down in 20 words or less
Lightning round of definitions
Brian: You’re all different! Crowd: Yes, we are all different! Man: I’m not, I’m the same
Source: “Life of Brian” movie
Richard Dale, COO, Optum Labs for MassTLC Big Data and Personalized Medicine. Copyright © Optum Labs 2013, all rights reserved. 7
Are we treating the disease (which one?) or the patient?
Source: “Prevalence of multiple chronic conditions in the US Medicare population” Schneider, O;Donnell, Dean Health and Quality of Life Outcomes 2009, 7:82
Richard Dale, COO, Optum Labs for MassTLC Big Data and Personalized Medicine. Copyright © Optum Labs 2013, all rights reserved. 8
Delivering Personalized Medicine: Everyone is an N-of-1
An example of a power law graph showing popularity ranking. To the right (yellow) is the long tail; to the left (green) are the few that dominate. In this example, the areas of both regions are equal. Source: “Long tail”, Wikipedia
If Amazon and Netflix can deliver individualized “personalized” recommendations from analysis of thousands of factors, perhaps healthcare should have ambitions to do the same.
Well
Sick
Delivering Personalized Medicine Healthcare
Mapping Personalized Healthcare
Richard Dale, COO, Optum Labs for MassTLC Big Data and Personalized Medicine. Copyright © Optum Labs 2013, all rights reserved. 11
Healthcare based on your N-of-1 with evidence-based screenings & interventions:
Population health
management Disease
pre-cursor discovery
Disease prevention & management
Precise diagnosis
Biomarkers Disease
Characterization
Treatment option
analysis
Drug suitability screening
Disease & treatment
progressions
Natural history of disease
Evidence from clinical and
administrative record
Richard Dale, COO, Optum Labs for MassTLC Big Data and Personalized Medicine. Copyright © Optum Labs 2013, all rights reserved. 12
Dimensions of Personalized Healthcare and Big Data
Up & running In development Where next
Population health management
Disease pre-cursor discovery
Disease prevention & management
Precise diagnosis
Biomarkers
Disease characterization
Treatment option analysis
Drug suitability screening
Disease & treatment progressions
Natural history of disease
Evidence from data record
