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Pain nourishes courage. You can't be brave if you've only had wonderful things happen
to you. – Mary Tyler Moore
CLINICAL PATHOLOGYThe foundation of clinical medicine.
Shashidhar Venkatesh MurthyA/Prof & Head of Pathology
College of Medicine & Dentistry
BPH2: Urinary Tract Dis: UTI
CPC : Term4 Week3 - BPH 2/6System : Urinary Tract.Topic : 1: Overview 2: UTI 3: BPH 4: Tumours 5: Obstructions Lithiasis 6: Others 7: GLS
3
UTI: Overview Urethritis, Cystitis, Prostatitis, Pyelonephritis 90% by Escherichia coli *, Recurrence (40%), Uropathogenic strains (UPEC). P fimbriae or pili
– bind to urothelium. Colonize colon spread to urinary tract. Staph. Saprophyticus, Proteus, Klebs., Entero.,
Ureaplasma.. - Rare
Clinical: Females*, Anatomy*, sexual, UT abnormality /
Obstructions. Dysuria, Low grade fever, frequency, urgency, Flank pain, high fever, – pyelonephritis. Complications: E coli septicemia* endotoxins
DIC*, Prostatitis, Prostatic abscess.
A friend is someone with whom you dare to be
yourself.– Frank Crane
5
UTI: Diagnosis: E coli Blood: Leukocytosis – neutrophilia Midstream clean catch Urine specimen* Dipstick: Leukocyte esterase & nitritie +ve. Urine: pyuria, neutrophils, bacteria,
Microscopy gram stain: Gram negative Bacilli, Lactose fermenting. Also Entero.. & Klebsiella ferment lactose. Further tests to confirm: E coli urease –ve
(unlike Klebsiella & Proteus +ve)
MacConkey agar* selective, indicator media. 24h, 37°C, Aerobic, Pink colony
(lactose ferment acid pH indicator), Beta-hemolytic on blood agar.
A friend is someone with whom you dare to be yourself.
– Frank Crane