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Title : Nanoscale human
interventions to enhance bioavailability of Curcumin
in the treatment of Alzheimer's disease
By: Kushali
Jain.D
M.pharma
Introduction Alzheimer’s disease is the commonest
progressive neurodegenerative disorder of elderly population, characterized by memory dysfunction, spatial and temporal disorientation and impairment of judgment clinically.
In Alzheimer’s disease, a peptide referred as amyloid beta aggregates (oligomers), and accumulates in the brain to form deposits called as amyloid plaques.
Curcumin Turmeric (Curcuma longa) is an amazing ingredient with a rich traditional history as a dietary spice and herbal supplement in ancient china and India.
This characteristic yellow colored spice, derived from the rhizome of the plant (C. longa), is a member of Zingiberaceae family and is widely cultivated in India and Southeast Asia.
Benefits of curcumin
Epidemiological studies Various studies and research results indicate a lower incidence and prevalence of AD in India The prevalence of AD among adults aged 70-79 years in India is 4.4 times less than that of adults aged 70-79 years in the United States. Researchers investigated the association between the curry consumption and cognitive level in Asians between 60 and 93 years of age. The study found that those who occasionally ate curry (less than once a month) and often (more than once a month) performed better on a standard test mini mental state examination (MMSE) of cognitive function than those who ate curry never or rarely
Mechanism of Alzheimer's disease and role of Curcumin
Cleavage
STRESS, INJURY
Protective mechanism
α- secretase β- secretase
40 amino acid Cleavage (42-amino acidgroups)
A-β fibril plaques(intracellular)
Cont…..
Curcumin
Evert insidious evolution
It helps macrophages to clear amyloid-β plaques found in AD
Curcumin has shown
1. Anti inflammatory property2. Anti-oxidant property
Oxidative damage
Inflammation
β –Amyloid plaques in Brain
Intracellular aggregates
Synaptic loss,
Neuron dysfunction
Dementia
Uses of Nano technology
Curcumin Vs Nanocurcumin
Free Curcumin
Poorly dispersible in waterReduced Bioavailability
Nanocurcumin
Dispersible in water Sustained drug release
kinetics Improved Bioavailability Improved cellular uptake
Nano robot Drug delivery system
Nanorobotics is emerging field of a nanotechnologyNanorobot skeleton Made up
Carbon and its tool kit ContainMedicine cavity
Consist ofMedicine, Micro camera, payload, Capacitor
As nano robot have special sensor which detect target molecule in Human body
Used in treatment ofVarious disease which include Cancer ,Diabetes,
Alzheimer's etc.
ConclusionBased on the above details this novel Nano Curcumin may have great potential for AD therapy and can be a reference for future studies on formulation of drugs using Nano technology.
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