Magnetic Resonance Imaging of the Rhesus Monkey Brain

• Roland Tammer• Sabine Hofer• Klaus-Dietmar Merboldt• Jens Frahm

ISBN: 978-3-525-40424-9 Website: http://www.v-r.de/en/items/978-3-525-

40424-9

All images are low resolution samples.

Magnetic Resonance Imaging of the Rhesus Monkey Brain

Magnetic resonance imaging (MRI) of the central nervous system plays an increasingly important role in the neurosciences involving humans and animals. Nonhuman primates are of special relevance because of their immunological, physiological, and behavioral similarities to humans. Therefore, the lack of detailed anatomical MRI data of the rhesus monkey brain was a strong motivation for this work. It provides the first comprehensive in vivo MRI atlas of the living macaque brain at the highest technical quality currently available.

Three-dimensional coverage of the brain in horizontal, coronal, and sagittal sections at unprecedented 0.5 mm isotropic spatial resolution is at the core of the atlas with an indication of anatomical structures. Multiple contrasts are supplied compatible with human MRI.

Advanced techniques such as magnetic resonance angiography and diffusion tensor imaging are exploited for a visualization of the intracranial vasculature and the virtual reconstruction of nerve fiber tracts, respectively.

“Readability” for the non-expert is ensured by a simple introduction into the principles and applications of MRI. Detailed descriptions cover all aspects of animal handling, experimental procedures, and image presentation in a stereotaxic coordinate system.

The atlas is expected to serve as a reference source for easy identification of anatomical structures in the rhesus monkey brain. It is a “must” on the desktop of primatologists and neuroscientists in a broad range of disciplines.

Table of Content

7 Preface9 Introduction11 Technical Aspects11 Magnetic Resonance Imaging12 Image Contrast14 Experimental Details15 Animals16 Image Presentation19 Anatomical MRI20 Horizontal Sections108 Coronal Sections181 Sagittal Sections208 Surface Reconstructions220 Intracranial Vasculature220 Magnetic Resonance Angiography221 Experimental Details222 Intracranial Arteries226 Nerve Fiber Tracts226 Diffusion Tensor Imaging228 Fiber Tractography229 Experimental Details232 Major Nerve Fibers244 Anatomical Variability249 Abbreviations250 References252 Index262 Authors

Jens Frahm Sabine Hofer

Klaus-Dietmar Merboldt

Jens Frahm

Roland Tammer

Roland Tammer, Ph.D., is Scientific assistant at Biomedizinische NMR Forschungs GmbH and DFG Center for Molecular Physiology of the Brain, Göttingen.

Vita1996 Doctoral degree in veterinary

medicine, Justus-Liebig-Universität, Giessen, Germany; 1994 Small animal veterinary surgeon; 2000 Scientific assistant, Deutsches Primatenzentrum GmbH, Göttingen, Germany.

Main FocusMagnetic resonance imaging studies

of laboratory animals.

Sabine Hofer

Sabine Hofer, Ph.D., is Scientific assistant at Biomedizinische NMR Forschungs GmbH and Bernstein Center for Computational Neuroscience, Göttingen, Germany.

Main FocusStructural and functional aspects of

the primate central nervous system with the use of functional magnetic resonance imaging, diffusion tensor imaging, and fiber tractography; comparative neuroanatomy of human and nonhuman primates.

Klaus-Dietmar Merboldt

Klaus-Dietmar Merboldt, Ph.D., is senior scientist at Biomedizinische NMR Forschungs GmbH, Göttingen, Germany.

Vita1984 Doctoral degree in physical

chemistry, Georg-August-Universität, Göttingen, Germany; 1985 Scientific assistant, Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany.

Main FocusAdvanced methods for functional

magnetic resonance imaging of human brain activation and diffusion tensor imaging of nerve fibers.

Jens Frahm

Jens Frahm, Ph.D., is director of Biomedizinische NMR Forschungs GmbH (non-profit), Göttingen, Germany and Professor for physical chemistry, Georg-August-Universität, Göttingen.

Vita1977 Doctoral degree in physical

chemistry, Georg-August-Universität, Göttingen, Germany; 1982 Head of Biomedical NMR research group, Max-Planck-Institut für biophysikalische Chemie Göttingen, Germany.

Main FocusDevelopment and application of magnetic

resonance imaging techniques for noninvasive studies of animals and humans with a special emphasis on the neurosciences.

• 263 Pages with many coloured illustrations

• ca. 30,5 cm x 35,5 cm (12 inch x 14 inch)

• ISBN 978-3-525-40424-9 • Webpage at Vandenhoeck &

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