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“Bringing world class innovations to market by bridging discoveries into
commercial products.”
Successful Commercialization – The Cleveland Clinic Story
Thomas SudowDirector of Business Development
How Many Patients Were Touched Today By Innovations from
the Cleveland Clinic ?
• Blood Transfusion• Kidney Dialysis• Angiography• Bi-Pass Surgery
From just these 4 –
MILLIONS !!!
Add up the rest
Well over 5 Million
TODAY
Since 1921A Unique Model of Care
Since 1921A Unique Model of Care
• Four doctors share a vision- Non-profit, physician-led
group practice
- Collaboration across disciplines
- All physicians are salaried
- Patient-centered mission
FRANK E. BUNTS, MD
JOHN PHILLIPS, MD
GEORGE CRILE SR., MD
WILLIAM E. LOWER, MD
• 5.5M Patient Visits
• 43,430 Employee Caregivers
• 27 Institutes providing care in 120 subspecialties
• Locations• Main Campus• 8 Community Hospitals • 16 Family Health Centers in NE Ohio• Facilities in Florida, Nevada, Toronto & Abu
Dhabi
• EMR Leader – My Chart
• Top 4 Hospital by U.S. News & World Report
Cleveland Clinic
Main CampusMain Campus
Cleveland Clinic Lou Ruvo Center for Brain Health
Cleveland Clinic Lou Ruvo Center for Brain Health
7
Cleveland Clinic Abu DhabiCleveland Clinic Abu Dhabi
ClevelandClinic
HHFairview Hospital
Lakewood Hospital
HH
Lutheran Hospital
HH
Ashtabula County Medical Center
HH
Euclid Hospital
HH
Hillcrest Hospital
HH
South PointeHospital
HH
Marymount Hospital
HH
ClevelandClinic
Florida
HHMedinaHospital
HHLorain Family HealthAnd Surgery Center
FHCFHC
Elyria FamilyHealth Center
Westlake FamilyHealth Center
FHCFHC
FHCFHC LakewoodFamily Health
Center
FHCFHC
Strongsville Family Health and Surgery Center
FHCFHC
Brunswick FamilyHealth Center
FHCFHCWooster FamilyHealth Center
FHCFHC
Independence FamilyHealth Center
FHCFHC Solon FamilyHealth Center
FHCFHC
Chagrin Falls FamilyHealth Center
FHCFHC
Beachwood FamilyHealth and Surgery Center
FHCFHC
Willoughby HillsFamily Health Center
FHCFHC
FHCFHC
R.E. JacobsHealth Center
Lou Ruvo Centerfor Brain Health
Las Vegas, Nevada
FHCFHC
ClevelandClinic
Toronto
FHCFHC
S.T.J. Health Center
HC HC
Twinsburg FamilyHealth Center
FHCFHC
6.4M Patients6.4M Patients
Cleveland Clinic Culture
"We are considering not only our duty to the patient of today, but no less our duty to the patient of tomorrow."
Quality. INNOVATION. Teamwork. Service. Integrity. Compassion.
We welcome change, encourage invention and continually seek better, more efficient ways to achieve our goals.
George Crile, Sr., MD Co-Founder Cleveland Clinic
Cleveland Clinic Innovations
We promote innovation and expand treatment of the sick through the deployment of technologies developed by Cleveland Clinic and our Healthcare Innovations Alliance Partners.
Through commercialization, we translate emerging diagnostics, therapies, devices, health IT and business solutions into beneficial medical products through spin-off companies, licenses and equity partnerships.
Promote Innovation via Commercialization
• Bring new innovations into widespread clinical practice
• Protect the intellectual property underlying the innovations
• Optimize the value returned for those innovations
• Grow the regional economy and beyond
Areas of Focus
1. Commercialization / technology transfer
2. Global Healthcare Innovation Alliance
3. Medical Innovation Summit
4. Centers (GCIC & NCAI)
Business Imperatives
• Commercializing/translating innovations that provide better patient care;
• Delivering exceptional inventor satisfaction through teamwork;
• Optimizing financial outcomes.
Innovations Scorecard: 2014Innovations Scorecard: 2014
• 2,600 Patent Applications• 450 Royalty Licenses• 71 Spin-Offs• $799M in Equity Investments• $69M to Inventors• $167M in State & Federal
Grants• 1,200 Jobs Created• World-Wide Recognition
Innovations Key Metrics
*IDFs include Alliance Partners
IDFs
Pate
nts
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 0
5
10
15
20
25
30
35
40
0
50
100
150
200
250
300
350
400
450
500
Agreements Companies Formed Patents Filed Patents Issued IDFs
Agre
em
ents
Com
panie
s
Inventions by Type 2014
Medical Device50%
Health IT23%
Therapeutics & Diagnostics
22%
Delivery Solutions5%
Portfolio Companies: 712000-2003
2004-2005
2006 20072008-2009
2010 2011 2012 2013 2014
ART SARL CleveX Clear Catheter Solutions
ATI Congruent Medical
NaviGate iComet iVHR RenovoBiosciences
Adeo
AxioMed IntElect Tolera CardioNomic OptoQuest Image IQ Custom Arthroplasty
SolutionsFlexLife Health
Shield Biotech
Centerline Medical
CardioMEMS Merlot Revasc Cleveland Heart
Perfusion Solutions
SironRX Custom Ortho
Solutions
Infuseon Jace Medical
VBT
Cleveland BioLabs
CSF Therapeutics
Alios Biopharma
Navis Renovo Neural
YouDocs Beauty
Enspire DBS
Ion-VAC Cancer Genetics
Emanate Wireless
Peritec PrognostiX Juventas Clear Catheter Systems
Buckeye Ocular
Enforcer PluronX i360Medical Cleveland Diagnostics
ValveXchange OrthoMems AngioQuest Cleveland HeartLab
Sivan Panacela* RelateCare
BioSil, USA
VioQuest Explorys Incuron* Rindex Talis
Z-Kat Zin Medical
Intellis I-Lyte IPPC
Ridgeway Simbionix Clear Ventric
Esperion
Therapeutics Non-operatingDeviceDiagnosticsHIT Services
Monetized
Dissolved*CBLI Spin-off
A Comprehensive Approach
Mine for IDEAS with clinically aligned Institute Innovation Managers
Engage clinical and technical inventor peers to evaluate NEED
Assess the commercial VIABILITY and build a business case
Develop within a domain specific incubator for ENHANCEMENT, then market
Manage NEGOTIATIONS to create spin-offs, licenses and equity partnerships
Take idea through TRANSLATION to improve patient care
Cleveland Clinic Innovations Incubators
Medical Device Therapeutic Health IT Delivery
Solutions
Industry & Investor Advisory
Process FlowProcess Flow
Peer Review (PRC)CCI Facilitated, Enterprise Aligned,
Institute Driven
• Inventor Satisfaction
• Greater Awareness of Innovation
• Expanded Involvement
• Improved Commercial Outcomes
• Increased Transparency for Stakeholders
• Access to Clinical, Technical, & Industry Experts
• Enhanced Quality
• Increase Value
Value Proposition & Outcomes
The Global Healthcare Innovations Alliance is a collaborative network of healthcare systems, academic institutions and corporate partners around the world. The Alliance creates opportunities that benefits patients everywhere through scalable technology development and commercialization.
Partnering to Realize Opportunities
The Global Healthcare Innovations Alliance connects members with the world class commercialization services of Cleveland Clinic. bEach partner brings unique capabilities, contributing to a multilateral network.
In addition to innovation management and commercialization, The Alliance aims to identify intersections that can combine efforts in research, clinical investigation and technology development. The value of partnering with the Alliance lies in the unique 360-degree perspective on patient care and innovation, established connections to resources throughout the healthcare and industry community, and a deep and wide-ranging commercialization capabilities and expertise.
Partnering to Realize Opportunities
2015 Medical Innovation Summit2015 Medical Innovation Summit
Innovation Centers at Cleveland Clinic
Translating Research to Development and Commercialization
Complementary Programs
• Heart, Lung, Blood, Sleep• Institution-Based Projects• Establish Proof of Concept• 1 Year Scope of Work• Project Guidance• Milestone Reviews• Grant Funding• $50K - $150K + 1:1 Match• Next Stage: SBIR, GCIC
• Cardiovascular• Company-Based Projects• Early-Stage Development• 1 Year Scope of Work• Project Guidance• Milestone Reviews• Convertible Debt Funding• $300K - $500K + 2:1 Match• Next Stage: VC Financing
Global Cardiovascular Innovation Center
Mission and Scope• Catalyze economic development by
developing, incubating andcommercializing cardiovasculartechnology
• A consortium of university, hospital,industry, and economic developmentpartners within Ohio
• $60M grant from Ohio Third Frontier Project, 2007
• Also managing
• Goals:- Job Creation: 855 at average wage of $69,500- New Venture-Backed and Recruited Companies: 43- Seed and Venture Capital Invested: $207M
GCIC Programs• Commercialization Funding
Provide seed funding and support to new product development
• Product Development Acceleration
Provide product management and business planning support by industry-experienced staff
• Business Attraction
Bring new businesses to Ohio to grow the Cardiovascular cluster
• New Company Incubation
Operate and manage incubator facility for start-up companies
• Preclinical Investigation Capabilities
Operate state-of-art preclinical facility for sponsored research, product development, procedure training
GCIC – a Successful Catalyst and Magnet for New Business in Ohio
• 58 Commercialization Funding Awards Granted.- $18.6M awarded for development of 48 technologies- Supporting 38 companies and 8 institution-based projects
• 22 New Businesses Attracted to and Operating in Ohio.
• GCIC Incubator facility supporting 30 companies.
• 861 Added Ohio Jobs in Companies Funded, Attracted or Incubated by GCIC. Growing steadily as companies mature
• $763 Million in Follow-on Funding, M&A Returns Secured. Growing significantly as companies secure additional later round financing
As of end Q4 2014
Commercialization Success
• Advancing technology into physician’s handsand into service to patients
• Progress of 48 Technologies Funded…
Development
Preclinical Validation
Clinical Trials
Acquisition Transaction or In Market
8
12
12
8
Research4
NIH Center for Accelerated Innovations (NCAI) at Cleveland Clinic
• Mission to improve how basic science advances and discoveries are translated into commercially viable productsthat improve patient care and advance public health.
• One of three inaugural NCAI’s established.
• $10M grant from NHLBI to Cleveland Clinicto establish a multi-institutional consortium of academic, clinical, government, non-profit and private sector organizations within Ohio.
• Targeting technologies to improve diagnosis, treatment, management and prevention of heart, lung, blood and sleep disorders and diseases.
• 7 year program to provide funding and project management forfeasibility studies, regulatory, legal, and business development expertise;and entrepreneurial training and mentorship.
OHIO HEALTHCARE INNOVATION ALLIANCE
Why Ohio…. Why Now?• Compelling Opportunity• Shared Challenges• Natural Relationships• Governor’s Priority• Innovation: Collaboration & Success
OHIO HEALTHCARE INNOVATION ALLIANCE
• Large Scale Assessment of Innovation Capacity on the State level
• Disciplined Process and Propriety Evaluation Instruments the OHIA diagnostics was conducted to:• Determine Level of Collaboration• The Existence of an Innovation Infrastructure • The Identification of a collective promising portfolio• Determine the Potential for a State-Wide Innovation
Alliance that will Distinguish Ohio as an Innovation Leader
Lessons from the Global Innovation Alliance
•Major Advantages of Collaboration•Cross-Pollination•Activate All Forms of Innovation: 5-Points of Star•Access to Resources•Leverage Scale
OHIO HEALTHCARE INNOVATION ALLIANCE
Governor-Nominated Participants
“The future belongs to those who seize the opportunities created by innovation."
Delos M. Cosgrove, MD CEO & PresidentCleveland Clinic
Stay Connected!Stay Connected!
innovations.clevelandclinic.org
