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METHODS, MATHEMATICAL MODELS, DATA QUALITY ASSESSMENT AND RESULT INTERPRETATION: SOLUTIONS DEVELOPED IN THE IFEDH FRAMEWORK G. Zauner dwh Simulation Services Vienna , Austria
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METHODS, MATHEMATICAL MODELS, DATA QUALITY ASSESSMENT AND RESULT
INTERPRETATION: SOLUTIONS DEVELOPED IN THE IFEDH FRAMEWORK
G. Zauner
dwh Simulation ServicesVienna , Austria
1. Decisions have to be made in Austria
2. Advanced data structures, HTA methods and new modeling techniques
3. Interdisciplinary project tasks
4. „Good Practice“ guidelines, limited development duration
The IFEDH project
IFEDH – Framework: Basics
IFEDHNetwork
Decision Makers Provider
Ministry
Provinces
Social Security
Pharmaceutical Industry
Medical Technology
Medical Provider
Informations for Generating Evidence Based Decision on Basis of Models for Possible Strategies
CUSTOMER
Services
The IFEDH Network
IFEDH: Services
IFEDH – Framework: Partner
• Modeling experts (theoretical development and practical solutions)
• HTA experts (Main Association of Austrian Health Security Services, Ludwig Boltzmann Institute - Health Technology Assessment)
• Data structure and DQA experts• Statisticians• Web developer and programmer• Centre for Virtual Reality and Visualization
1. State of the Art detection and guideance for practical use in:
I. Modeling
II. HTA Techniques
III. Visualization
IV. Data Sources and Data Quality Assessment
V. Validatation and Verification
2. Modular and hybrid modeling technique development
3. Data source evaluation and HTA-manager tool
4. Proof of concept
IFEDH – Framework: Structure
IFEDH – Framework: Structure
HTA question
Data structures HTA techniques
Modular models
Hybrid models
DQA Visualization
ValidationVerification
ResultInterpretation
IFEDH – Framework: Structure
IFEDH – Framework: Proof of Concept
Disease ModelSocial Interaction Model
Population Model
Economic Model
1. Seasonal influenza epidemicsAgent based model / modular structure
2. Human papillomavirus (HPV) vaccination and cancer treatmentODE model + Markov structure
3. Abdominal aortic aneurysm (AAA) screeningbottum-up modeling, cost module
Feedback to data structure
internal data (HVB, clinical trials, …)
external data
Pool of Methods- AB- SD, ODEs- couplings- …
Hybrid decom-position
modelcom-parison
EvaluationInsigths for data structureexternal evaluation
Feedback to model pool
Problem classdefinition
economicalpoint of view
modeldemand
Feedback to data structure
Including modeling techniques in HTA
An interdiciplinary process for model based HTA is under development
Modeling and Simulation plays a key role in decision making in advanced HTA questions
Modular structures allow faster decision support and guarantee approved model structures/model assumptions
Knowledge combination of different domains is an import basis for successful solution of socio-economic questions in HTA and EBM
Conclusion
Thank you very much!