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Realizing the Potential of the Natural Products Industry in Western
North Carolina A collaborative project funded by
Why WNC?
Biodiversity Mild climate Culture of active, healthy
lifestyles Licensed alternative
healthcare providers Agricultural and business
support Natural products
business cluster ◦ Gaia Herbs ◦ King Bio ◦ Golden Needle
Acupuncture Supply ◦ Sanesco ◦ Ancient Sun ◦ Genova Diagnostics
Photo: Nathan Johnson, Gaia Herbs
Project goals
Natural Products business development ◦ Train workforce ◦ Guide new clients through production ◦ Create jobs
Raw materials development ◦ Train farmers, wildharvesters, extension agents ◦ Develop analytical methods for botanical material
evaluation & marketing Regional brand
Online marketplace
Natural Products Project Partners
WNC Naturally workshops
◦ Sustainable harvesting ◦ Voucher specimen
preparation ◦ Market opportunities ◦ Connect to wholesale
buyers ◦ Dietary supplements
cGMP ◦ “Train the trainer”
event for extension agents and teachers
Photos: Alison Dressler, NCSU
Analytical methods for locally native or cultivated plants
Caffeine in Yaupon holly (Ilex vomitoria) Alkaloids berberine & hydrastine in
Goldenseal (Hydrastis canadensis) Triterpene glycosides in black cohosh
(Actaea racemosa) Flavonoids in passionflower (Passiflora
incarnata)
Photo: “Plants to People,” http://www.advantagegreen.org/clusters/natural-products/
Analytical methods for Chinese herbs with local potential
Saponins in Chai hu (Bupleurum
chinensis) Isoflavones in kudzu (Pueraria lobata) Lignans in Wu wei zi (Schisandra) Ligustilide in Dong quai (Angelica
sinensis) Flavones in Huang qin (Scutellaria
baicalensis)
Angelica sinensis
• Dong quai root • Ingredient in many TCM
formulations • z-Ligustilide & ferulic
acid are quality control markers
• Single HPLC-UV method to quantify both compounds in a methanolic extract
Photos: luckyvitamin.com
Medicinal herb comparison
Chinese Ju hua WNC Chrysanthemum
Natural Products Project Year 2
Waiting for Golden
Leaf update on funding status
Implement analytical methods for brand users
Developing USP2021 microbiological capabilities: ◦ Total microbial count ◦ Total yeast & mold ◦ E.coli & Salmonella
(qualitative)