Classification of Fluroquinolones

1st generation

nalidixic acid

2nd generation

Ciprofloxacin,Enoxacin,Ofloxacin,Lomefloxacin, Norfloxacin,

3rd generation

Levofloxacin,Gatifloxacin,gemi

floxacin,grepafloxacin, Sparfloxacin,

4th generation

Trovafloxacin,Moxifloxacin

Mechanism of actionBactericidal against susceptible organism.It interferes with bacterial DNA synthesis by inhibiting 2 important bacterial enzymes.Topoisomerase II: Topoisomerase (II ) DNA gyrase is responsible for relaxing supercoiled DNA during normal transcription.Topoisomerase IV:

Topoisomerase IV interferes with separation of chromosomal DNA During cell division

Dosage schedule of LefoxinType of infection Dosed every

24 HoursDuration (days)

Nosocomial pneumonia 500mg 7-14

Community Acquired pneumonia 500mg 7-14

Acute bacterial sinusitis 500mg 10-14

Acute bacterial exacerbation of chronic bronchitis

500 mg 7

Complicated skin an skin structure infection (SSSI)

500mg 7-10

Uncomplicated SSSI 500mg 7-10

Chronic bacterial prostatitis 500mg 28

Complicated Urinary tract Infection or acute Pyelonephritis

250mg 10

Uncomplicated Urinary tract Infection

250mg 3

Dosage schedule of LefoxinAge Comparator Drug dosage

Dosage

Six months to younger than five

years

22.5 mg per Kg amoxicillin/calvulanic acid (Augmentin) oral

suspension twice daily9maximal

dosage 875 mg per day

10 mg per Kg oral

suspension twice daily (maximal

dosage per day)

Am Fam physician (2008) Mar 15;77(6):838-842

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