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Incretins Gastrointestinal hormones that enhance food-induced insulin secretion

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Most important incretinGLP-1

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GLP-1Secreted by the L cells of the intestine

Predominantly in the ileum and colon Secrete proglucagon from which GLP-1 is derived

Stimulus Ingestion of food

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GIPGlucose-dependent insulinotropic

polypeptideReleased into the bloodstream from K

cellsDuodenum and proximal jejunum

StimulusFood

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K cells and L cells

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Actions of GLP Slows gastric emptying Release insulinImproves hepatic insulin resistanceIncrease beta cell mass

Stimulate the production of new beta cells from stem cells in the pancreatic duct

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