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ICU RESEARCH POINTS
2014-20151
SAMIR EL ANSARY
Global Critical Carehttps://www.facebook.com/groups/1451610115129555/#!/groups/145161011512
9555/ Wellcome in our new group ..... Dr.SAMIR EL ANSARY
Propofol may prevent or limit reparative
processes in the early-phase postinjury. The results therefore indicate that anesthetics may
be potentially harmful not only in very young mammalians but also in adult animals following acute
cerebral injuries. The results provide first evidence for an altered
sensitivity for anesthesia-related negative effects on neurogenesis, functional outcome, and survival in
adult rats with brain lesions.
Preliminary Report on Cardiac Dysfunction After Isolated
Traumatic Brain Injury
cardiac dysfunction during the first 2 weeks after isolated traumatic brain injury and its association
with in-hospital mortality.
Cardiac dysfunction was defined as left ventricular ejection fraction less than 50% or presence of regional wall motion abnormality.
Preliminary Report on Cardiac Dysfunction After Isolated
Traumatic Brain Injury
Cardiac dysfunction in the setting of isolated traumatic brain injury occurs and is associated with increased in-hospital mortality. This finding raises the question as to whether
there are uncharted opportunities for a more timely recognition of cardiac dysfunction and subsequent
optimization of the hemodynamic management of these patients.
Association of Low Serum 25-Hydroxyvitamin D Levels and Sepsis in the Critically Ill
25-hydroxyvitamin D deficiency prior to hospital admission is a significant predictor of sepsis in the
critically ill. Additionally, patients with sepsis who are not vitamin D sufficient have an increased risk of
mortality following critical care initiation.
Treatment With Neuromuscular Blocking Agents and the Risk of In-Hospital
Mortality Among Mechanically Ventilated Patients With Severe Sepsis*
Recent trials suggest that treatment with neuromuscular blocking agents may improve survival in patients requiring
mechanical ventilation for acute respiratory distress syndrome. We examined the association between receipt of a
neuromuscular blocking agent and in-hospital mortality among mechanically ventilated patients with severe sepsis.
Treatment With Neuromuscular Blocking Agents and the Risk of In-Hospital
Mortality Among Mechanically Ventilated Patients With Severe Sepsis*
Among mechanically ventilated patients with severe sepsis and respiratory infection, early
treatment with a neuromuscular blocking agent is associated with lower in-hospital mortality.
Effects of Propofol on Patient-Ventilator Synchrony and Interaction During Pressure Support Ventilation and Neurally Adjusted
Ventilatory Assist
With neurally adjusted ventilatory assist, ineffective triggering index fell to 0%, regardless of the depth of
sedation. With both modes, deep sedation caused a significant
increase in PaCO2, which resulted, however, from different breathing patterns and patient-ventilator
interactions.
Effects of Propofol on Patient-Ventilator Synchrony and Interaction During Pressure Support Ventilation and Neurally Adjusted
Ventilatory Assist
In pressure support ventilation, deep propofolsedation increased asynchronies, while light sedation
did not. Propofol reduced the respiratory drive, while
breathing timing was not significantly affected. Gas exchange and breathing pattern were also
influenced by propofol infusion to an extent that varied with the depth of sedation and the mode of
ventilation.
Bundle of Measures for External Cerebral Ventricular Drainage-Associated Ventriculitis
the prevalence and outcome of external cerebral ventricular drainage-associated ventriculitis in
neurocritical patients before and after the implementation of a bundle of external cerebral
ventricular drainage-associated ventriculitis control measures.
Bundle of Measures for External Cerebral Ventricular Drainage-Associated Ventriculitis
The bundle of external cerebral ventricular drainage-associated ventriculitis control measures included
1) reeducation of ICU personnel on issues of infection control related to external cerebral ventricular drainage,2) meticulous intraventricular catheter handling,
3) cerebrospinal fluid sampling only when clinically necessary, and
4) routine replacement of the drainage catheter on the seventh drainage day if the catheter was still necessary.
Bundle of Measures for External Cerebral Ventricular Drainage-Associated Ventriculitis
Measurements: External cerebral ventricular drainage-associated ventriculitis prevalence, external cerebral ventricular drainage-associated ventriculitis
events per 1,000 drainage days (drain-associated infection rate), length of ICU stay, Glasgow Outcome
Scale at 6 months, and risk factors for external cerebral ventricular drainage-associated ventriculitis.
Bundle of Measures for External Cerebral Ventricular Drainage-Associated Ventriculitis
The implementation of a bundle of measures for external cerebral ventricular drainage-associated ventriculitis control
was associated with significantly decreased postintervention prevalence of the
infection.
Providing effective enteral nutrition is important during critical illness.
In health, glucose is absorbed from the small intestine via sodium-dependent glucose transporter-1 and glucose
transporter-2, which may both be regulated by intestinal sweet taste
receptors. The effect of critical illness on glucose absorption and
expression of intestinal sodium-dependent glucose transporter-1, glucose transporter-2, and sweet taste
receptors in humans
The Effects of Critical Illness on Intestinal Glucose Sensing, Transporters, and
Absorption
The Effects of Critical Illness on Intestinal Glucose Sensing, Transporters, and
Absorption
Critical illness is characterized by markedly diminished glucose absorption, associated with
reduced intestinal expression of glucose transporters (sodium-dependent glucose
transporter-1 and glucose transporter-2) and sweet taste receptor transcripts.
Global Critical Carehttps://www.facebook.com/groups/1451610115129555/#!/groups/145161011512
9555/ Wellcome in our new group ..... Dr.SAMIR EL ANSARY
