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CASE PRESENTATION DEPARTMENT 31

Hypercoagulability presentation

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CASE PRESENTATIONDEPARTMENT 31

Personal History

Female patient M.A. 65 years old, House wife, married with 14 offspring youngest is 35 years old, living in Elsaff ,with no special habits of medical importance.

Complaint

Pain and swelling of left leg

Present History

Condition started 5 days before admission by pain and swelling of left leg of gradual onset and progressive course, the pain was related to calf, not radiating, bursting, increasing by prolonged standing or walking and decreasing by elevation of the affected leg.

The edema was persistent, increasing by standing and decreasing by elevation of the leg.

The condition is not associated with fever, and not preceeded by trauma, surgical operations or intake of any drugs.

The condition is not associated with chest pain, hemoptysis or dyspnea.

The patient suffered from left hypochondrialstitching pain two Months ago and sought medical care, U/S and CT abdomen were and the condition was diagnosed as multiple splenic and renal infarctions.

No history of:

Arthralgias or arthritis

Photosenstivity

Oral ulcers

Excessive hairfall

No history of:

Rapid weight loss

Generalized body swellings

Severe headache, projectile vomiting or blurring of vision.

Chest pain or hemoptysis.

Right hypochondrial pain or jaundice.

Persistent bony pains.

No history of previous strokes, TIAs, myocardial infarctions, intestinal infarctions or limb ischemia.

No history suggestive of other systemic diseases.

The patient is not known to be hypertensive.

Past History

history of previous similar condition.

History of cataract operation done 20 years ago.

Family History

No similar conditions in the family.

Positive consanguinity.( The parents are cousins.)

Obstetric

No history of previous abortions

EXAMINATION

The patient is fully concious, of average mood, and well oriented to time, place and person.

Examination

Vital Signs:B.p.:120/80Pulse:80, Regular, of average pulse volume, equal bilaterally, with no special character. Peripheral pulsations are intact. Arterial wall is not felt.Temp: 37.5R.R.: 20RBS:269

No jaundice

No Pallor

No cyanosis

Carotid pulsations are of average volume and equal bilaterally

No congested neck veins

No thyroid swelling

No cervical lymphadenopathy

Limb examination

Upper limbs:

No clubbing or cyanosis

No flapping tremors or palmar erythema

Lower limbs:

Left lower limb edema, redness and tenderness

Tense calf muscles of the left lower limb

Palpable dorsalis pedis and posterior tibial

Cardiac examination

Inspection:

Apex lies in the 5th space in the MCL

No visible pulsations

Palpation:

No palpable pulsations or thrills

Auscultation:

Normal S1 and S2

No additional heart sounds

No murmurs, rub or gallop

Chest examination

Inspection:

No scars or sinuses or pigmentation

Palpation:

No tenderness

Normal TVF

Percussion:Normal lung resonance

Upper border of the liver in the 5th

MCL

Auscultation:

Normal vesicular breathing

No wheezes or crepitations

No bilateral basal crepitations

Abdominal examination

Inspection: No pigmentation, scratching marks or

sinuses

Palpation:

Superficial palpation:No rigidity, tenderness or rebound

tenderness.No superficial masses.

Deep palpation:

No palpable organomegaly.

Percussion:

No detectable ascites

Auscultation:

Audible intestinal sounds

Neurological examination

Intact cranial nerves.

Normal tone, power and reflexes.

Intact sensation.

Normal coordination.

Joint examination

Normal range of movement of all joints.

No redness or tenderness of any joints.

Lymph node examination

No cervical, axillary or inguinal lymphadenopathy.

Musculoskeletal examination

No sternal tenderness.

INVESTIGATIONS

LABS

ESR

FIRST HOUR :

52

SECOND HOUR: 89

CBC

TLC 7.9RBC’S 3.86Hemoglobin 10.1Haematocrit 30.9M.C.V 79.9 M.C.H 26

M.C.H.C 32.6

RDW 16.5PLATELETS COUNT 129

Mild microcytic hypochromic anemia.

RBCs show anisocytosis.

Mild thrombocytopenia.

Coagulation profile

PT : 23.8

PC : 31.3 %

INR: 1.88

PTT: 38 ( 28-40 sec.)

Chemistry

BIL-T 1.24

BIL-D 0.56

ALAT 33

AST 40

Albumin 3.6

TGs 89

Cholesterol 188

Urea 28

Creatinine 0.9

Calcium 8.7

Phosphorus 3

LDH 369

(135-225)

Na 143

K 3.8

T.Ptn 6.2

Alb 3.3

FBS 157

Urine analysis

Color : yellow

Reaction: Acidic

Sp.gravity : 1015

Proteins : +

Sugar : Nil

Acetone : Nil

Bile pigment : Nil

Pus cells : 8-10

RBCs : 10-15

Crystals : Nil

Casts : Nil

Epithilial cells: Nil

Immune profile

ANA : +ve speckled and nucleolar

C4 : 39.9 ( 10-40)

C3 : 159 (90-180)

Anti-ds DNA : Pending

ANCA : Pending

Lupus anticoagulant : 133

Anticardiolipin : Pending

Anti-B2-glycoprotein 1 IgG AM screen :

56 (Up to 10 )

Protein C : 37 ( 82-110)

Protein S: 61 ( 71-113)

Tumor markers

AFP : 2.5

CA 15-5 : Pending

CA19-9 : Pending

CA125 : Pending

IMAGING

Duplex

Ultrasound

CT Neck

CT chest

CT abdomen