TrastuzumabHerceptin

Presented by:

Fatima Batool (04)

Noor-ul-Huda (27)

Trastuzumab

US brand name: Herceptin

FDA approved : Yes

• A recombinant humanized

monoclonal antibody

• against human epidermal

growth receptor 2 protein

(HER2)

Use

• Approved to be used alone or with

other drugs to treat:

• Adenocarcinoma of stomach or gastro

esophageal junction.

• used for HER2 positive(HER2+) disease that

has metastasized (spread to other parts of the

body) in patients who have not already been

treated for metastatic cancer.

• Breast cancer that is HER2+.

• HER2 overexpressed by many adenocarcinomas,

particularly breast adenocarcinomas

• Overexpression of the HER2 protein, amplification

of the HER2 gene, or both, occur in approximately

15-25% of breast cancers

• associated with aggressive behaviour in the

tumour

• for women with breast cancer who have

an overexpression of HER2

• herceptin might be useful as adjuvant

therapy (before/after/in combination) with

established other chemotherapeutic

agents

• (eg anthracyclines and taxanes), surgery

and radiation treatment.

• has survival benefit when given with

chemotherapy to patients

• with early, operable, and metastatic breast

cancer that has HER2 overexpression or

amplification

Mode of action

• After binding to HER2 on the tumor cell

surface, trastuzumab induces an antibody-

dependent cell-mediated cytotoxicity

against tumor cells that overexpress HER2

Trastuzumab mediates ADCCOnce bound to the Fc domain of trastuzumab, the NK cells release substances…

that perforate the tumour cell membrane and promote cell death

Epidemiological studies assessing

Herceptin effectiveness

Fig 3: Journal of the New Zealand Medical

Association, 02-June-2006, Vol 119 No 1235

Side effects

• diarrhea

• constipation

• heartburn

• loss of appetite

• back, bone, joint, or muscle pain

• difficulty falling asleep or staying asleep

• numbness, burning, or tingling in the arms,

hands, feet, or legs

• changes in the appearance of nails

Serious side effects

• Cardiac failure

• sore throat, fever, chills, difficulty

urinating, pain when urinating, and

other signs of infection

• nosebleeds and other unusual

bruising or bleeding

• excessive tiredness

• pale skin