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The Healing Brain
A Scientific Reader
Robert Ornstein and
Charles Swencionis,
(editors)
Candace Pert
Receptors
Receptors for External Opiates(Exogenous ligand)
morphine
heroinopium
codeine
Endogenous Ligands(internal opiates)Beta-endorphin
http://micro.magnet.fsu.edu/micro/gallery/endorphin/endorph2.jpg
Peptide produced by nerve cells
in the brain
http://pdelagrange.free.fr/povlab/demopic/neurons.jpg
Neuropeptides
Opiate receptors20,000 amino acids
20 amino acids阿片制劑感受器
The Biochemistry of Emotions
Hypothalamus
( 丘腦下部 )
(homeostasis)
Pituitary ( 垂體 )(regulates hormone)
Amygdala ( 杏仁核 )(fear)
Opiate receptors in limbic system
Hypothalamus
丘腦下部40-fold higher with
opiate receptors
Walter B Cannon
Many of the neuropeptides are
hormones produced by the glands
and not by nerve cells, e.g. insulin胰島素
Hormones stores in
one place of the
body and travel to its
receptors in other
parts of the bodyhttp://micro.magnet.fsu.edu/micro/gallery/hormones/hormone.jpg
夷島素Insulin
• Insulin secreted by pancreas
• BUT—insulin also found to be made and stored in the brain
• In amygdala and hypothalamus
Nodal points
• Points that receive a lot of emotional modulation
• We have found that for virtually all the senses for which we know the entry area, the spot is always a nodal point for neuropeptides receptors
Angiotensin
• Mediates thirst• Found in brain and in
kidney
血管緊張素
CCK
• Found in brain, gut and spleen
• Food satiety – makes you not want to eat
• From esophagus to the large intestine – all lined with nerve, neuropeptides opiate receptors
Cells in immune systemMonocytes
The new discovery I want to emphasize here is that every neuropeptide receptor that we have looked for is also on the human monocytes.
These emotion-affecting biochemicals [neuropeptides]actually appear to control the routing and migration of monocytes.
The cells of the immune system not only have receptors for these various neuropeptides, … they also make the neuropeptides themselves.