1Learnignorance will disappear of itself!
1Clinical Pathology: RBC 1.4: Congenital Hemolytic AnemiaCPC: Term2 Week1 - Haem 1/2.System: Haematology - RBC Disorders.Topic: 1: Anemia Intro 2: IDA, MBA & ACD 3: Acquired HA 4: Congenital HA. 5: Others... foundation of clinical medicine Shashidhar Venkatesh MurthyA/Prof & Head of PathologyCollege of Medicine & Dentistry2Pathogenetic Classification of Anemia:Decreased Production:Nutrient Deficiency. Iron def (IDA) / Megaloblastic (MBA)Hemopoietic cell defect:Anemia of chronic disorders (ACD)Aplastic anemia (AA).Dysplastic anemia. Myelodysplastic SyndromesIncreased loss / destruction:Blood loss anemia Acute / Chronic - bleeding. Hemolytic anemia Congenital / Acquired.Acquired / External injury.Immune AIHA (Warm/Cold) Mechanical, Drugs & ParasitesCongenital / Internal RBC defectDefective Membrane: Hereditary Spherocytosis.Defective Hemoglobin: Sickle & Thalassemia Deficient Enzyme: G6PD deficiency anemia.33Cell MemHb.Enzymes3Hereditary Spherocytosis: Spectrin deficiency*4
Chronic hemolytic anemia (from birth or late)Plenty of spherocytes. (more than in WAHA)Massive splenomegaly.Cholecystitis and cholelithiasisAplastic, megaloblastic or hemolytic crisis(Combs test negative)4Hereditary Spherocytosis:5
Normal spleen size of a fist!
SplenomegalySplenectomy: Therapy for severe HS5
G6PD Deficiency: Oxidative hemolysisG6PD deficiency.Oxidative damage (old RBC)Heinz bodies (globins)Bite & blister cells (dry RBC*)Episodic Hemolysis.Splenomegaly, gall stones..6
6"Thinking should become your capital asset, no matter whatever ups and downs come across in your life.Dr. APJ Abdul Kalam, Former President of India..
Physiologic anemia change from Hb F to Hb A.Hb A 22 - 97%Hb A2 22 - 2.5%Hb F 22 -