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Dr Patrick Dixon Chairman Global Change Ltd Fellow, Centre for Management Development, London Business School What Future for Biotech ?

Future of Biotech, Innovation in Healthcare - Conference Keynote Speaker

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http://www.globalchange.com Future of health care, from sickness to performance, disease prevention, health promotion and wellbeing, wellness. Impact of ageing, older people, senior citizens - growing health care demands. Health trends in treatment of genetic disease, inherited medical conditions, HIV, Alzheimers, Parkinsons, Diabetes, Rheumatoid Arthritis etc. How patients, clients, over the counter therapy customers, and consumers of health care products will manage their own treatment. Patrick Dixon is a health care keynote speaker at many public health conferences and forums on future of the pharmaceutical industry. Patient choice and public health policy changes with government budget health cuts, health care rationing, post code lotteries. How doctors and nurses will manage patients who often know more about their own medical condition, have made their own diagnosis, have made decisions about their own treatment (patient autonomy). Impact on over the counter pharmaceutical industry, chemists, drug stores, pharmacies and retail sales of health related products. Wellbeing, disease prevention, health promotion, vitamin and health supplements, dietary supplements are all changing consumer behaviour. How computer aided diagnostics will change clinical management of many medical conditions in hospital, clinics and in community care settings. Health care management and allocation of resources will be influenced by community-based diagnostics. Future of the pharmaceutical industry with non-prescription medicines, remedies, therapies, drugs. Prescribing new treatments using new diagnostic tools, and patient clinical care pathways. Health policy development by governments, and health insurance companies. Patient survival and increase in life expectancy with early diagnosis and treatment using equipment bought by consumers for home use. Future of the NHS and national health service, Medicare in America. Funding of health care in future -- people expected to fund their own health needs.

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Page 1: Future of Biotech, Innovation in Healthcare - Conference Keynote Speaker

Dr Patrick Dixon Chairman Global Change LtdFellow, Centre for Management Development, London Business School

What Future for Biotech ?

Page 2: Future of Biotech, Innovation in Healthcare - Conference Keynote Speaker

Patrick Dixon is Chairman of Global Change Ltd, Author of 15 books and has been ranked one of the 20 most influential business thinkers alive today (Thinkers 50)

Future of Biotech, Innovation in Healthcare for Novo Nordisk (2012)

500 videos of keynoteswww.youtube.com/pjvdixon

over 4 million views

www.globalchange.com14 million unique visitors

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Wild  Cards:  Risk  Management

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Web - SMS

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Global Brand Growth

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Indonesia: Islamic radicalisation88% of 200 million

Expect struggle for political power by radical groups in Indonesia, Malaysia

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1 billion children cities

Demographics - Future World and future Novo Nordisk

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Middle Class --> food --> diabetes: 300m India - 100m Africa

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18 million children in Turkey will be adults in next 15 years

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Europe Dying

4 couples needed to produce just one

great-grandchild

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75% of all US and UK wealth owned by those over 65

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1 million voters over 90 years old in Italy by 2026

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Growing global gap - rich and poor 100 own equivalent 25% of GDP in India

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Future Health = emotion

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Future in developed markets is about performance not wellness

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“Yesterday’s drugs were about need: tomorrow’s will be about living faster and staying young”

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People Want to Look Better•51% growth in botox treatment•31% growth laser hair removal•31% growth in cosmetic surgery enquiries•(UK 2007 2008)

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Sexual Performance

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Brain Faster – and better?

may be

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Remote diagnostics and image reporting Your own personal tech may be better than in hospital

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Genetic Prophecy – Are We Ready?

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Read Human Genome in an Hour•Fluidics•Biochemistry•Genetics•Mathematics•Immunology•Robotics

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Innovation in Ageing

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Permanent Hair Colour•Adenovirus • Infected mouse hair cells•Permanent colour change

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Worn out Mitochondria – Energy Boost

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KB-141 Thyroxine Analogue Boosts Metabolism

•$100 billion / year cost to US economy of OBESITY / DIABETES•1 in 3 babies born in New York --> Type 2 Diabetes

•Synthetic form of thryroxine increases metabolic rate•Obese monkeys lost up to 7% of body mass in 7 days•Heart rates were unchanged•Karo Bio made KB-141 - tested by Bristol-Myers Squib

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Treatment which restores and maintains the youthful elasticity of hardened arteries – and

helps wrinkled skin. Global sales?

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Caloric Restricted Mice Live LongerStephen Spindler Biomarker Pharmaceuticals

These animals also develop fewer cancers – but prone to infection / other problems

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Monkeys on diet live longer•After 20 years - 80% alive v 50% on normal calories•Less cancer, diabetes, heart disease, strokes, brain decay

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•Age-onset diabetes Rx for many years •Extends lifespan of non-diabetic mice by 20% if started in late middle age

•Few side effects or toxicity when given to non-diabetic humans

•Rapid growth in self-medicated people hoping to extend healthy living

•Cost 20 cents a day•70% of age-related gene changes in mice are reversed in 2-4 weeks with caloric restriction

•Similar changes are found when using metformin

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Near-perfect repair of heart or brain damage following

coronary / strokeusing adult stem cells

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Your Brain Can Repair

ItselfDaily

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We can transform cells in a laboratory – but far better would be to transform them where they

are in the body, using pharma products

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Diabetes – New Approaches•Direct transformation of liver to healthy pancreatic cells using simple injections every three months…

•Achieved in tadpoles and in human liver culture

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Slow or no ageing is a reality

•Rockfish, Turtles, some Whales

•No signs of getting old

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Impact on Budgets and Health Rations

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Making a Difference - a Better World

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•Share your vision

•Show people why it really matters

•Show people how we will get there

•Give each person an important part to play

•Celebrate each success along the way

Creating a Better FutureLiving the strategy in your own team

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Dr Patrick Dixon Chairman Global Change Ltd

Slides and Videos: globalchange.com

14 million visitors - 4 million videos

Page 62: Future of Biotech, Innovation in Healthcare - Conference Keynote Speaker

Patrick Dixon is Chairman of Global Change Ltd, Author of 15 books and has been ranked one of the 20 most influential business thinkers alive today (Thinkers 50)

Future of Biotech, Innovation in Healthcare for Novo Nordisk (2012)

500 videos of keynoteswww.youtube.com/pjvdixon

over 4 million views

www.globalchange.com14 million unique visitors