Functional nutrition: Briefs and insights

Denton Coleman

www.satoriinstitute.info

Denton Coleman, Satori Institute Founder

• Bachelor of Science in Human Performance

• Certified Exercise Physiologist: ACSM

• Certified Strength and Conditioning Specialist: NSCA

• Certified Orthopedic Exercise Specialist: ACE

• Certified Holistic Fitness Specialist: AHF

• Certified Personal Trainer: ACSM

Overview• Gastrointestinal health

• Food allergies/sensitivities

• Immune health

• Detoxification

“He who does not know food, how can he understand the disease of man?” -Hippocrates

“When diet is wrong, medicine is of no use. When diet is correct, medicine is of no need.” - Ayurvedic proverb

Gastrointestinal health• Food-grade diatomaceous earth can be an excellent go-to for helping

to break down microbial biofilms within the gut (diatomaceous earth can also act as a notable chelation agent) [1] [2] [3]. Combining diatomaceous earth with high-quality bentonite clay is recommended so that after the biofilms have been dismantled, the clay can then bind to and help remove the unwanted material from the colon (as well as other toxins) [4] [5].

• The claim made by Anthony William regarding diatomaceous earth’s affinity for adhering to the intestinal wall and interfering with mineral absorption is not only fallacious but idiotic. Please be careful and discerning in your research of nutritional advice.

Gastrointestinal health• In repairing digestive function, betaine hydrochloride and various

digestive enzymes can be wondrous when used judiciously. Individualizing the protocol to present issues like weakened parietal cells (which produce hydrochloric acid and intrinsic factor) or chief cells (pepsinogen and gastric lipase), a hindered pancreas, abnormal gut motility (things aren’t moving through as they should), and food sensitivities is always advised.

• Like diatomaceous earth, hydrolytic and proteolytic enzymes can be used to deconstruct microbial biofilms, with proteolytic enzymes also being able to aid in the reduction of intestinal inflammation [6] [7] [8] [9]. Though we must remember that continued use of supplemental enzymes can downregulate the body’s own production of enzymes as feedback loops register a plentiful quantity from the exogenous source.

Gastrointestinal health• Eating raw leafy greens before flesh foods can increase the number of

enzymes available to help break down and digest the flesh foods.

• When attempting to repair the digestive tract, many grains, nuts, and seeds may need to be avoided temporarily in order to prevent the interference of phytic acid upon digestive enzyme function.

• However, the soaking of nuts, seeds, and grains (in addition to further techniques of preparation) can reduce phytic acid levels appreciably.

Gastrointestinal health• Bodily dehydration rapidly elevates stress hormone levels,

disrupting digestion and hormone production. A decent target to shoot for is the consumption of half your body weight in ounces of water each day.

• Distilled and non-mineralized water can pull internal water from the body, which is why individuals who start drinking such water usually have to urinate often – the body is trying to remove the “vacuuming” water from its interior.

• Here’s a quality water filter bottle from REI = http://www.rei.com/product/881836/grayl-quest-water-filtration-cup-trail. A good rule of thumb is to drink about 2 cups of water or so about 30 minutes before a meal, and then try to only drink a little bit of water during the meal to wash the food down.

Gastrointestinal health• The utilization of supplements and vitamins that are taken from

sick, unhealthy plants is obviously not recommended as such supplements can operate as concentrated doses of “sick” components of the unhealthy plants. Therefore, organically-sourced supplements are greatly superior.

• As the work of Dr. Royal Lee has shown, nutrients do not exist in isolation within whole food sources – vitamins, minerals, fats, carbohydrates, enzymes, proteins, and co-factors (such as terpenes, alkaloids, and phenols) exist and operate within complexes.

• Thus, taking isolated supplements can force the body to gather the missing components of the natural complex from its interior so that the isolated nutrient from the supplement may be effectively utilized. This process can lead to a chasing of nutrient deficiencies – where one deficiency is addressed while another is created in its place.

Gastrointestinal health• Celtic sea salt and Himalayan pink salt can be helpful in addressing

adrenal fatigue as these forms of salt can promote remineralization of the body, for adrenal stress increases the rate at which the adrenal glands “burn through” vitamins and minerals.

Gastrointestinal health• A huge portion of the body’s immune system exists as the gut-

associated lymphoid tissue (GALT), the largest collection of lymphoid tissue in the body [10]. The GALT must be on guard constantly to alert the rest of the immune system to encounters with pathogenic or problematic matter in the gut, and this tissue plays a pivotal role in maintaining the integrity of the intestinal wall, modulating intestinal inflammation, and protecting against microbial infection [11].

• Note that beneficial bacteria play a big part in helping immune cells that have migrated to the GALT (after having been born in the bone marrow) to mature properly [12].

Gastrointestinal health• Some beneficial gut bacteria are capable of modulating the

manufacture of neurotransmitters like gamma-amino butyric acid (GABA) and serotonin, as well as the protein brain-derived neurotrophic factor (BDNF) [13] [14].

• Focusing on BDNF, this protein is involved in the protection of existing neurons and the growth of new neurons, in addition to the enhancement of cognitive function and recall [15] [16] [17].

• On the flip side, low levels of BDNF have been associated with such conditions as Parkinson’s disease, Alzheimer’s disease, depression, and schizophrenia.

Gastrointestinal health• Neurotoxins that enter the brain and damage nerve cells can easily

decrease the amount of available neurotransmitters which can lead to strong food cravings (largely by lowering serotonin levels as serotonin acts as an appetite suppressant).

Gastrointestinal health• Insomnia or trouble sleeping can be tied to dysbiosis in the gut as

some intestinal bacteria are involved in the release of cytokines like tumor necrosis factor and interleukin-1 that help to induce deep sleep [18] [19].

• These cytokines are normally released in concert with our circadian rhythm and cortisol fluctuations, but gut dysbiosis can interfere with their release and make it more difficult to gain restorative sleep.

Gastrointestinal health• Two of the major bacterial phyla comprising the human microbiota are

the Firmicutes and Bacteroidetes, and together these two divisions of bacteria make up the greatest part of the gut’s microbial population [20]. Because of their capacity to increase fatty acid absorption and energy extraction from ingested foodstuff, as well as alter genetic expression in favorance of weight gain, the Firmicutes are seen as being more proinflammatory and obesogenic in general [21] [22] [23].

• Note that multiple inflammatory messengers can interfere with fat loss by convincing adipose cells to hold on to their housed triglycerides, rather than allowing them to be released and oxidized.

• Fortunately, by simply increasing your intake of dietary fiber and polyphenol-containing foods, you can improve your ratio of Bacteroidetesto Firmicutes [24] [25]. Some good sources of polyphenols include: apples, grapes, blueberries, elderberries, pecans, cloves, and peppermint. Lastly, good ol’ fashioned exercise has also been shown to improve the Bacteroidetes/Firmicutes ratio [26].

Gastrointestinal health• An important point to make that many fail to understand, is that

intestinal exposure to gliadin (a class of proteins within the gluten family) conjures an increase in intestinal permeability in every human, not just those with Celiac Disease or Non-Celiac Gluten Sensitivity [27].

• This is why some have gone so far as to say that, to an extent, everyone is gluten sensitive. Furthermore, the above fact immediately invalidates the claims made by multiple imbeciles in the medical arena that Non-Celiac Gluten Sensitivity doesn’t exist.

• I also want to mention here that anti-gliadin antibodies (antibodies created in response to gliadin exposure) are capable of cross-reacting or binding with neural proteins (specifically, synapsin Ia and synapsin Ib), possibly affecting neurotransmitter release, liver epithelial cell function, and pancreatic beta cell function [28] [29] [30].

Gastrointestinal health• Something worth mentioning here is that the ingestion of wheat

germ agglutinin (WGA), a lectin that can be found in wheat, rye, barley, and rice, may directly damage the health of joint and arterial tissues via WGA’s affinity for N-acetylglucosamine and N-acetylneuraminic acid (both of which are used in the construction of glycocalyces) [31].

• In those who consume wheat, barley, rye, or rice, the use of glucosamine supplements for joint pain essentially redirects the binding of WGA away from bodily N-acetylglucosamine and toward the supplemented form of glucosamine [32]. The better option for allaying joint pain then, would be to simply stop ingesting WGA.

Gastrointestinal health• Excessive stimulation of CB1 receptors (one of the endocannabinoid

system receptors) in fat cells can decrease the production of the hormone adiponectin, lower fatty acid oxidation, and dampen insulin sensitivity (promoting weight gain and the development of Type 2 diabetes) [33].

• Overactivity of the endocannabinoid system can result from inflammation of the intestines and adipose tissue [34] [35].

Gastrointestinal health• Because of the direct neural connections between the enteric nervous

system and the gallbladder and pancreas, inflammation, dysbiosis, or other errancy within the ENS may negatively impact the function or activity of these two organs (such as the release of bile or digestive enzymes) [36] [37].

Gastrointestinal health

• Probiotic implantation via a rectal suppository may help to fortify the colonic mucosa, reduce colonic inflammation, change the expression of immune-related genes, and of course alter the microbial population of the large intestine [38]. A probiotic supplement that contains multiple Bifidobacterium strains would be ideal for use in a probiotic suppository [39].

• Rectal suppositories can be made with coconut oil and a suppository mold or round ice cube tray. Simply fill a section of the mold or ice cube tray about halfway with coconut oil, open and add the contents of a probiotic capsule (you might add the contents of more than one capsule depending on the supplement you’re using) to the section you’ve partly filled, and then fill the remainder of the section with more coconut oil. If you’d like to make more than one suppository, you can fill more than one section of the tray or mold employing the same procedure. Finally, place the tray in the freezer until frozen and then the suppository will be ready for its adventure.

• It would be best to insert the rectal suppository right before going to bed so the oil and probiotic can be held for plenty of time (you might notice a little leakage in the morning).

Food allergies/sensitivities• When you experience an allergic response to a food, often your heart

rate will increase by about 10-20 beats, showing that the immune system has been activated.

Food allergies/sensitivities• Rotation dieting affords the body (the GI tract and immune system

in particular) a break from being exposed to and having to deal with identical or similar profiles of nutrients, antinutrients, and toxins from ingesting the same or related foods too frequently.

• Sticking to a four-day rotation plan should provide enough time for consumed foods to be cleared from the body before they are eaten again, and this avoidance can be very helpful (even necessary) for preventing the formation of hypersensitivity or allergy to commonly consumed foods.

Food allergies/sensitivities

• Continual exposure to foods that an individual is reacting abnormally or excessively to, can cause the appearance of acute symptoms to transition into chronic symptoms (or the absence of symptoms), as the body attempts to adapt itself to the consistent exposure [40]. For instance, problematic responses to ingested food may mimic such conditions as appendicitis, gallbladder diseases, and bowel or intestinal obstruction [41].

• The displaying of signs or symptoms (and the rapidity of such displaying) as a result of exposure to environmental toxins or foods to which the individual is currently hypersensitive or allergic to, can be highly variable and may fluctuate both in manner and degree [42].

• Also, we have to look at abnormal or allergic responses to food within the larger context of aggregate challenges and stressors (e.g., heavy metals, electromagnetic radiation, nutrient deficiencies, pancreatic insufficiency, microbial infection, etc.) to the body, chiefly the immune system.

• For instance, a simple lack of methyl donors or poor methylation capacity can facilitate excessive immune reactions to allergens or antigens presented to the body (as well as obstruct the “outgrowing” of such reactions).

Food allergies/sensitivities• Using the term addiction somewhat loosely, Dr. Theron Randolph

has explained the main two phases of food addiction thus: “(1) an immediate improvement of chronic symptoms of illness, such as tiredness, headache, fatigue, or aches and pains, when the food is eaten and then (2) a delayed hangover unless the addicting food or drink is taken on schedule. Each individual establishes his own addiction routine, his own pattern of ever-decreasing periods between food “fixes.” By taking his addicting food, the addict keeps himself in a relatively “high” state and postpones feelings of letdown, hangover, or pain that follow withdrawal of the addicting food” [43].

Food allergies/sensitivities• Illustrated a bit differently, a food addict’s response to their baneful

food may begin from a notable “low,” progress to a significant “high” after consumption, fall to a deep “low,” and then return to the notable “low” which has become the individual’s norm.

• Remember that the individual may have no idea that the food they are continually seeking is what is dragging them along their roller coaster of distress. Many folks will not associate their symptoms with their favorite foods or the foods they eat very frequently.

Food allergies/sensitivities

• Rotating foods that are of the same or similar genetic lines or within the same “food families” helps to avoid cross-reactivity to foods related to those an individual is reacting problematically to. For instance, if you eat a tomato for lunch on Monday, it would be best to wait until at least Wednesday before you have eggplant (both tomato and eggplant are part of the nightshade family).

• Generally, spacing identical foods by about four days is ideal, while related foods can usually be eaten with less time in-between (like the above example). However, if one is reacting strongly to a particular food, they may need to avoid all members of that food’s family for a time. Exactly how long is tough to say as many factors can keep the immune system on high alert or in a mild state of confusion, but a few months of avoidance is common. After that period, the offending food may be reintroduced, and the individual’s tolerance can be assessed.

• Lastly, be careful with supplements, especially vitamin and mineral supplements that have not been sourced from organic, whole foods, as not only may you be exposing yourself to unnecessary preservatives and chemical pollutants, but also additives that are sourced from foods to which you may be allergically reacting.

Food allergies/sensitivities• Making sure that your digestive capacity is at least adequate, and

ensuring that you chew your food thoroughly can help prevent against the formation of food sensitivities and allergies by precluding the gut’s immune cells from reacting abnormally to ingested food.

• Allergic reactions may also be driven by excessive histamine production via intestinal bacteria as a result of protein putrefaction.

Food allergies/sensitivities• Lists of food families can be found through various websites as well

as from the medical textbook Clinical Ecology: https://www.amazon.com/Clinical-Ecology-Lawrence-D-Dickey/dp/0398034095/ref=la_B001HPWSJI_1_1?s=books&ie=UTF8&qid=1487993107&sr=1-1.

Immune health• The genetic modification of common crops like wheat, corn, and soy

has provided the Standard American Diet with not only abnormal and confusing genetic information, but also high concentrations of difficult-to-digest and problematic proteins, such as those found in the gluten family [44] [45].

• The entry of foreign or problematic proteins into the bloodstream can easily open the door to the development of a host of ill-health conditions, including autoimmune diseases by way of molecular mimicry or the deposition of immune complexes (a.k.a. antigen-antibody complexes) within tissues [46].

• The use of various proteolytic enzymes, taken in-between meals, can be of aid in clearing the blood of circulating immune complexes [47].

Immune health• Estrogen dominance from whatever means (such as significant

exposure to xenoestrogens in food), can increase one’s risk of autoimmunity by driving a shift toward Th2 dominance in which their lymphocytes (white blood cells) basically produce too many antibodies [48].

Immune health• Many different toxins can invite autoimmune attacks by altering

one’s DNA, RNA, or cellular proteins in a way that coaxes the immune system into mistaking their own tissue as foreign.

Immune health• Blood sugar instability and incompetence in easily clearing glucose

from the bloodstream is detrimental for innumerable reasons, one being the incitement of glycation – the binding of sugar to a protein or lipid – yielding “advanced glycation end products” (AGEs).

• AGEs are normally produced within the body, but their accelerated creation may promote oxidative stress, vascular inflammation, mitochondrial dysfunction, diabetic complications like retinopathy and neuropathy, kidney damage, and degeneration of brain tissue [49] [50] [51] [52] [53] [54].

Detoxification• When hormone receptors become damaged due to toxins or free

radicals, supplemental hormones can create further problems by feeding artificial information into endocrine feedback loops and accumulating to toxic and stressful concentrations.

Detoxification• Mercury in dental amalgam fillings can not only directly attack

nerve tissue once it leaches into the bloodstream, but can also give rise to problems along the pathway of the meridian associated with the filled tooth. For example, persistent shoulder pain, angina, or migraines can manifest from mercury’s interference with a particular meridian [55].

• Also, note that “hidden” mercury stores in the body can sometimes make it very difficult to completely clear up an overgrowth of Candida, so antifungal programs may need to take heavy metal toxicity into account.

Detoxification• In general, the mobilization and excretion of mercury from the body

may be hampered by a deficiency in zinc and selenium, depleted reserves of glutathione, and a lack of exercise [56] [57] [58].

• Production of glutathione by the liver and kidneys can be enhanced via supplementation of N-acetylcysteine, alpha-lipoic acid, or L-cysteine, as well as through the consumption of onions, garlic, or cruciferous vegetables (like kale, broccoli, cauliflower, Brussels sprouts, arugula, and bok choy) [59].

Detoxification

• Various chelating agents can be used to help pull heavy metals out of the body (from both intracellular and extracellular spaces) [60]. Commonly employed agents include DMSA (dimercaptosuccinic acid), DMPS (2,3-dimercapto-1-propanesulfonic acid), and EDTA (ethylenediaminetetraacetic acid). DMSA, DMPS, and EDTA can be administered orally, intravenously, or via a rectal suppository.

• A physician may also choose to combine chelating agents, possibly adding N-acetylcysteine or alpha-lipoic acid to a DMSA protocol, or using antioxidants like vitamin C and vitamin E to support the removal of heavy metals [61]. Some caution and prudence definitely need to be exercised in the use of agents like DMSA, DMPS, and EDTA however, as chelation protocols can result in the stripping of needed minerals (zinc, manganese, copper, and molybdenum, for example) and a simple transporting of heavy metals to a different location in the body without being excreted.

• Therefore, some kind of liver bolstering and/or some kind of cleansing or revitalization of the GI tract is typically suggested before medical chelation is attempted.

Detoxification• According to calculations performed by Hattis et al., interindividual

variability in detoxification capacity may be as high as 85- to 500-fold [62]. This is one reason why toxification can drive the appearance of so many different signs and symptoms, even in folks regularly exposed to the same plethora of toxicants.

Detoxification• Far-infrared sauna therapy can be greatly beneficial for mobilizing

toxins residing in subcutaneous fat tissue, while subjecting the body to much lower temperatures (and therefore stress) [63]. Far-infrared radiation may also improve lymphatic flow and inactivate some pathogenic microbes, in addition to having been shown to protect against oxidative stress [64] [65].

• Lastly, infrared radiation in general possesses potency in separating electrical charges in structured water, thus providing cells with additional energy (which may aid cellular detoxification by sparing ATP generation) [66].

Questions?

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