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Ezastatin ( The Art of Combination Therapy)

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Ezastatin combines 10 mg ezetimibe with 40 mg atorvastatin Marked improvement in lipid profile compared to plain Atorvastatin. Reduction in Oxidized LDL, an effect not achieved by up-titration of statin dose. Reduces cholesterol absorption specially in diabetic patients with CAD. Ezastatin with 40 mg atorvastatin concentration to benefit from pleiotropic effects of atorvastatin. Ezastatin reduces CIMT compared to standard and aggressive therapy. Higher safety profile than maximizing atorvastatin dose to 80mg

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Page 1: Ezastatin ( The Art of Combination Therapy)
Page 2: Ezastatin ( The Art of Combination Therapy)

Coronary Artery Disease Risk

Page 3: Ezastatin ( The Art of Combination Therapy)

Coronary Artery Disease Risk

Page 4: Ezastatin ( The Art of Combination Therapy)

Are LDL-C Goals The Same For All Patients With Dyslipideamia?

Page 5: Ezastatin ( The Art of Combination Therapy)

Coronary Artery Disease RiskATP III modification

Page 6: Ezastatin ( The Art of Combination Therapy)

Debate

Can we achieve these goals with Statin mono therapy alone ?

At which Statin concentration ? Is it enough to achieve normal lipid

profile only ? what else ? What about increase exogenous

cholesterol absorption in diabetics?

Page 7: Ezastatin ( The Art of Combination Therapy)

Coronary Artery Disease RiskStatins monotherapy limitations

Page 8: Ezastatin ( The Art of Combination Therapy)

Coronary Artery Disease RiskStatins monotherapy limitations

Page 9: Ezastatin ( The Art of Combination Therapy)

Fill the unmet need in lipid lowering managementEzastatin

atorvastatin + ezetimibe

Page 10: Ezastatin ( The Art of Combination Therapy)

MANAGEMENT OF DIABETIC DYSLIPIDEMIA: RECENT ADVANCES IN COMBINATION THERAPY

Page 11: Ezastatin ( The Art of Combination Therapy)

Fill the unmet need in lipid lowering managementEzastatin

atorvastatin + ezetimibe

Page 12: Ezastatin ( The Art of Combination Therapy)

Fill the unmet need in lipid lowering managementEzastatin

atorvastatin + ezetimibe

Page 13: Ezastatin ( The Art of Combination Therapy)

Fill the unmet need in lipid lowering managementEzastatin

atorvastatin + ezetimibe

Page 14: Ezastatin ( The Art of Combination Therapy)

Fill the unmet need in lipid lowering managementEzastatin

atorvastatin + ezetimibe

Page 15: Ezastatin ( The Art of Combination Therapy)

Fill the unmet need in lipid lowering managementEzastatin

atorvastatin + ezetimibe

Page 16: Ezastatin ( The Art of Combination Therapy)

Fill the unmet need in lipid lowering managementEzastatin

atorvastatin + ezetimibe

Page 17: Ezastatin ( The Art of Combination Therapy)

Fill the unmet need in lipid lowering managementEzastatin

atorvastatin + ezetimibe

Page 18: Ezastatin ( The Art of Combination Therapy)

Fill the unmet need in lipid lowering managementEzastatin

atorvastatin + ezetimibe

Page 19: Ezastatin ( The Art of Combination Therapy)

Fill the unmet need in lipid lowering managementEzastatin

atorvastatin + ezetimibe

Page 20: Ezastatin ( The Art of Combination Therapy)

Fill the unmet need in lipid lowering managementEzastatin

atorvastatin + ezetimibe

Page 21: Ezastatin ( The Art of Combination Therapy)
Page 22: Ezastatin ( The Art of Combination Therapy)

Fill the unmet need in lipid lowering managementEzastatin

atorvastatin + ezetimibe

Page 23: Ezastatin ( The Art of Combination Therapy)

Fill the unmet need in lipid lowering managementEzastatin

atorvastatin + ezetimibe

Page 24: Ezastatin ( The Art of Combination Therapy)

Fill the unmet need in lipid lowering managementEzastatin

atorvastatin + ezetimibe

Page 25: Ezastatin ( The Art of Combination Therapy)

Fill the unmet need in lipid lowering managementEzastatin

atorvastatin + ezetimibe

Page 26: Ezastatin ( The Art of Combination Therapy)

Fill the unmet need in lipid lowering managementEzastatin

atorvastatin + ezetimibe

Page 27: Ezastatin ( The Art of Combination Therapy)

Fill the unmet need in lipid lowering managementEzastatin

atorvastatin + ezetimibe

Page 28: Ezastatin ( The Art of Combination Therapy)

Why Ezastatin

Ezastatin combines 10 mg ezetimibe with 40 mg atorvastatin

Marked improvement in lipid profile compared to plain Atorvastatin.

Reduction in Oxidized LDL, an effect not achieved by up-titration of statin dose.

Reduces cholesterol absorption specially in diabetic patients with CAD.

Ezastatin with 40 mg atorvastatin concentration to benefit from pleiotropic effects of atorvastatin.

Ezastatin reduces CIMT compared to standard and aggressive therapy.

Higher safety profile than maximizing atorvastatin dose to 80mg.

Page 29: Ezastatin ( The Art of Combination Therapy)

Ezastatinatorvastatin + ezetimibe

Fill the unmet need in lipid lowering management

Page 30: Ezastatin ( The Art of Combination Therapy)
Page 31: Ezastatin ( The Art of Combination Therapy)
Page 32: Ezastatin ( The Art of Combination Therapy)

THANK YOU

Thank YOU