EGF

0 Human EGF is a 6045-Da protein with 53 amino acid

residues and three intramolecular disulfide bonds.

0 EGF acts by binding with

high affinity to EGFR on the

cell surface and stimulating

the intrinsic protein-tyrosine

kinase activity of the receptor.

0 Accelerate epidermal regeneration

of partial and full thickness skin wounds.

Background

But, the clinical use of rhEGF

in case of patients have generated some controversy in advantage.

Purposes

0 In this study,

0 Twelve patients had partial thickness wounds because of

burn and skin graft donor site were treated with rhEGF

0 We investigated the clinical effect of rhEGF on partial

thickness wounds of patients

Materials

0 Periods: Feb’08~Oct’08

0 Patients:

0 Patients that have second degree burn wounds (n=5)

0 Patients that have donor site wounds after skin graft (n=7)

0 Sex: all male

0 Age: 33.5

0 Exclusion: patients that have comorbidities,

such as DM or vascular diseases

Methods

0 Each wound was divided two areas (group A and B)

0 Marking 2 x 2 cm2 sized square shape

0 Treatment twice daily

0 Group A (experimental): foam dressing with rhEGF

0 Group B (control): foam dressing without rhEGF

Analysis

0 The extent of reepithelialized area was recorded by

percentage ratio

0 The statistical analysis was conducted about the

difference of the number of days between two area until

total wound was reepithelialized

Results

Patient Etiology of wound Group A

(days)

Group B

(days)

Difference

(A-B, days)

1 Second-degree burn 10 13 -3

2 Skin graft donor site 11 11 0

3 Skin graft donor site 8 10 -2

4 Second-degree burn 11 9 2

5 Skin graft donor site 8 10 -2

6 Skin graft donor site 9 12 -3

7 Second-degree burn 12 11 1

8 Skin graft donor site 8 9 -1

9 Second-degree burn 10 12 -2

10 Skin graft donor site 9 10 -1

11 Second-degree burn 11 14 -3

12 Skin graft donor site 10 12 -2

Results

0 Healing time

0 Group A: 9.75 days (8-10 days)

0 Group B: 11.08 days (9-14 days)

0 Statistically significant difference between two groups (P < 0.05)

Conclusion

0 The topical application of rhEGF

0 Accelerated the re-epithelialization

0 Healing of partial-thickness wound clinically