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1
EPILEPSYPresented by:
Post graduate studentsCourse: MD Phase A (Psychiatry)BSMMU, Dhaka18/8/2013
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Contents
•Introduction•Pathogenesis•Clinical features & Diagnostic approach•Management•Interphase & Summary
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IntroductionDr Towhidul Islam
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Past
•Oldest record SakikKu -babilonian medcal text 1067 B.C
•Aurvedic description as “Apasmara” 400 B.C
•“epilambanein” to be overwhelmed by surprise
•Falling sickness•Demonic possession
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Past
•“its cause lies in the brain”
•1920- Human EEG (Hans Berger)
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Basics
Seizure:
•Any clinical event•Abnormal brain discharge
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Basics
Epilepsy :
• Recurrence• Seizure attack
Pseudo seizure/PNES:
• Resemblance• Psychology• No abnormal brain discharge
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PNES
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Basics SEIZURE PSEUDO
SEIZURE SYNCOPE
• Sudden• Unconscious • Cyanosis• Injury• Sec to mints• Hand on
face• Post ictal
confusion• EEG,CPK,
Prolactin
• Gradual • Conscious • Thrusting• Mins to hr• Eye opening • Pupil-
Normal• Psycho
social• Suggestive
• Light headedness
• Standing• Preventive-
lying • Brief- lost
consciousness
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Current scenario
• 60 million people worldwide
• 85% people-inadequate/not at all
• Specialist care:LIC- 56%, HIC-89%
• AEDs: Govt priority, high cost , PB
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Current scenario
•Age: any age (childhood, old age)
•Prevalence: Single episode - 5%Repeated- 0.5 to 2.5%Our country- 2%Developing country- 5 times higher
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Classification
FOCAL (Partial)
GENERALIZED Unclassified-MAY BE Focal/Generalized/ Unclear
(Complex)With Dyscognitive features
(Simple) Without Dyscognitive features
AbsenceTonic ClonicAtonicMyoclonic
Epileptic spasmsFebrile convulsionInfeantile spasmLennox-Gastaut Sydrome
• Motor • Sensor
y• Versive• Visual
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Cause
•Family history 5 to 10% of all epilepsiesUsually- 10 GTCS, Febrile convulsion, Absence, Juvenile myoclonic epilepsy
•Primary generalized- 75% idiopathic
•Partial & 20 generalized- definite cause75% adult
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CauseNeonates<1 month
Infants < 12 years
Adolescents12-18 years
Young adult 18-35 years
Older >35 years
Perinatal hypoxia and ischemia
ICH
Ca++ , GlucoseBilirubin
Water intoxication
Inborn error of metabolismTrauma
Febrile seizures
CNS infection
Trauma
Developmental disorder
Inborn error of metabolism
Trauma
CNS infection
AVM
Infection
Congenital defect
Tumors
Trauma
CNS infection
Brain tumor
AVM
Drugs and alcohol
Drugs and alcoholTraumaTumor
CVD
Degenerative
CNS infection
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CauseGROUP Names
ALKYLATING AGENTS Busulfan, Chlorambucil
ANTIMALARIALS Chloroquine, mefloquine
ANTIMICROBIAL Beta lactam , Quinolones, Acyclovir, Isoniazid, Ganciclovir
ANESTHETICS, ANALGESICS
Meperidine, Tramadol, Local anaesthetics
DIETARY SUPPLEMENTS
Gingko, Ephedra
IMMUNOMODULATORY DRUGS
Cyclosporine, Tacrolimus, Interferron
PSYCHOTROPICS Antidepressants, Antipsychotics, Lithium
CONTRAST AGENTS Theophylline
SEDATIVE , HYPNOTIC (WITHDRAWL)
BZD, Barbiturates, Alcohol
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What happens inside?Dr Md Saleh Uddin
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Why & How?
•Shift of balance: Excitation & Inhibition(CNS)
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Why & How?
•Endogenous factor
Neuronal propensity to burst
Intrinsic : conductance to ion channel, receptor response, second messenger, translation etc.
Extrinsic : neuro transmitter, receptor, temporal /spatial property
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Why & How?
•Epileptogenesis
Transformation - normal to hyper excitable(structural change)
Lowered seizure thresholdLost inhibitionSprouting of surviving neurons
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Why & How?
•Precipitating factor
Sleep deprivationAlcoholRecreational drug misusePhysical and mental exhaustionFlickering lights Intercurrent infections and metabolic
disturbance
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What & How?
Seizure initiation and propagation
• Initiation: Bursts of action potentialHyper synchronization
• Propagation: Extracellular K+
Presynaptic Ca2+
Cortical connections& Commissural fibers
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Why & How?
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Updates
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Why & How?
Endogenous Factor
Precipitating Factor
Epileptogenic Factor
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Clinical features & Diagnostic approach
Dr Hosnea Ara
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GTCS/Grand mal
•Prodrome•Aura•Tonic phase•Clonic phase•Relaxation•Post ictal phase
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Absence Seizure
•Petit mal •Childhood•Frequency •Stops doing, vacant stares•Hyperventilation •No post ictal symptoms•EEG diagnostic
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Complex partial seizure
•Temporal lobe/psychomotor epilepsy•Never fall•Mood ,memory, perception•Features :
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Atonic seizure
•Brief loss of muscle tone•Heavy fall•Consciousness
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Simple partial
•Motor•Sensory•Versive•Visual
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Diagnostic approach
•History•Clinical exam•Lab enquiry•Differentials
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Diagnostic approach
•HISTORY
Age group Past history of illness Personal historyTriggering factorsEye witness description
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Diagnostic approach
•CLINICAL EXAM
General surveyVital signsCyanosis, JaundiceTongue bite mark
Systemic examNeurological, CVS, HBS, Resp
System
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Diagnostic approach
•LAB INQUIRY
Hematology BiochemistrySerologyCSF, Hormone, ECGImaging
• Late in onset • Partial / 2o
generalized• Refractory to drug• Focal neuro deficit• Status epilepticus• Suspected ICSOL• EEG shows focal
seizure
MRI/CT brain Indication
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Diagnostic approach
•LAB ENQUIRYEEG
Type of epilepsyDrug choice
Advanced lab testSphenoidal intra operative oval and
telemetric EEGAmbulatory EEG, VideotelemetryPET, SPET
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Diagnostic approach
•DIFFERENTIALS
SyncopeTIAMigraineDrop attackPanic attackHypoglycemiaCataplexy/NarcolepsyPseudoseizureCardiac arrhythmiaEpisodic confusion
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ManagementDr Mahjabeen Aftab Solaiman
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Management
•Immediate care•Medical treatment•Pregnancy•Status epilepticus•Surgical treatment
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Management
•Immediate Care:First Aid
MoveSemi proneAirwayDon’t insert
Immediately Patency of airwayO2, IV diazepam, blood
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Management
•Medical treatment
AEDs : Carbamazepine Na valproate PhenytoinPhenobarbitone
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Management
•Indication AEDs:
Single seizure( lesion , EEG, family history)
Unprovoked seizureAdult- > 1Child- > 2
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Management
•AEDs-
Single drug , Low dose, ComplianceSwitching3rd drug prior combinationTwo drugs at a timeResistant to drug- metabolic/structural
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Type First line Second line Third linePartial / Secondary GTCS
Carbamazepine LamotrigineNa ValproateTopiramaateTigabineGabapentin
ClobazamPhenytoinPrimidonePhenobarbitalOxcarbazepineLevetiracetamVigabatrinAcetazoalmide
Primary GTCS Na Valproate LamotrigineTopiramateCarbamazepine
PhenytoinGabapentinPrimidonePhenobarbital TigabineAcetazolamide
Absence Ethosuximide Na Valproate LamotirizineClonazepamAcetazolamide
Myoclonic Na Valproate Clonazepam PiracetamLamotrizinePhenobarbital
44
Management
AEDs withdrawal :
Control 2 to 4 yearsGradually, 6-12 months
Prognosis: Primary generalized
Absence-BestOthers- Recurrence
45
Management
Pregnancy
• AEDs: Enzyme inducerCongenital abnormalities(First
trimester)Number & risk %
• Folic acid supplement• Partial seizure-little risk• Vit K supplement
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Management
•Status epilepticusSeries of seizuresWithout regaining awareness30 minutes
Management: GeneralPharmacological
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Surgical treatment:
• 20-30% patients• Localization (video EEG, MRI, SPET,PET, Cortical
mapping at surgery)• Temporal lobectomy• Hemispherectomy • Corpus callosotomy • VNS
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Interphase & Summary
49
Interphase
50
Interphase
•Psychiatric disorders in epilepsy
50% patient with epilepsy.Ictal, peri-ictal , inter ictal (depression)
•Treatment related psychiatric problemDepression, psychosis etcAEDs (PB, Vigabatrin etc) “Forced normalization”
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Summary
History, Exam, Exclusion D/D
History of Epilepsy
Adequacy
Sub therapeutic
Level
Increase the dose
Therapeutic Level
Max dose, Alternative
drug
Lab features (biochemistry hematology)
Positive Treat the cause
No History of epilepsy
Lab features(Biochemistry, Hematology)
Positive Further work up
Drug
Normal Imaging
Treat cause Drug
Idiopathic Drug
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References• Davidson’s principal & practice of Medicine, 21st edition, elsevier
publisher, 2012• Harrison’s Principales of internal medicine, 18th edition. • Lecture Notes-Prof AKM Anwarullah• Epilepsia, 44(suppl 6): 12-143. 2003, Blackwell publishing Inc,
ILAE• History of epilepsy 1909-2009: The ILAE century• Recognition of psychogenic non epileptic seizure: acurable
neurophobia, S S O Sallivan et al, Journal of Neurosurg Psychiatry, 2013, 84: 228-231
• Why do some brain seize? Molecular ,cellular and network mechanism, Andrew Trevelyan, Jphysiol(editorial)591.4(2013) 751-752
• The treatment gap in epilepsy, A Neliga, J W Sander, Epileptology 1 (2013) 28-30
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“The sadness will last forever”(Vincent van Gogh)
Wheat field with crows (1890)
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Thank You