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ENDOGENOUS PIGMENTATION
ENDOGENOUS MELANOCYTIC PIGMENTATION
FARAKATH KHAN.MGuided byDr. Tatu Joy
MELANIN
CLASSIFICATION
FOCAL DIFFUSEMELANOSIS ASSOCIATED WITH SYSTEMIC OR GENETIC DISEASE
IDIOPATHIC PIGMENTATION
ORAL MUCOSA
ORAL MUCOSA
The normal color represents the combined effect of a number of factors:
The concentration and state of dilation of capillaries in the underlying connective tissue, The thickness of the epithelium, The degree of keratinization, And the amount of melanin pigment in the epithelium.
ENDOGENOUS PIGMENTATION
Hemoglobin, hemosiderin, melanin represent the most common endogenous source of mucosal color change.
HEMOGLOBINHAEMOGLOBIN & IRON ASSOCIATED PIGMENTATIONEcchymosisPurpura / PetechiaeHemochromatosis
melanin TYROSINE - DOPAMELANOCYTES(BASAL LAYER)MELANOSOMESMELANINEUMELANINPHEOMELANINTYROSINASE
CLEAR CELLS
MELANIN
MELANIN
MELANIN
MELANOCYTES
MELANIN
MELANIN INCONTINENCEMelanin is seen free or within melanophages in sub epithelial connective tissue.
CLASSIFICATION
FOCAL MELANOCYTIC PIGMENTATION
DIFFUSE PIGMENTATION FRECKLE/EPHELIS ORAL MELANOTIC MACULE ORAL MELANOACANTHOMA MELANOCYTIC NEVUS MALIGNANT MELANOMAPHYSIOLOGIC PIGMENTATIONDRUG-INDUCED MELANOSISPOST INFLAMMATORY PIGMENTATIONMELASMA(CHLOASMA)
MELANOSIS ASSOCIATED WITH SYSTEMIC OR GENETIC DISEASE
HYPOADRENOCORTICISM (ADDISONS DISEASE)CUSHINGS SYNDROMEHYPERTHYROIDISMPRIMARY BILIARY CIRRHOSISVITAMIN B 12 DEFICIENCYPEUTZ JEGHERS SYNDROMECAF AU LAIT PIGMENTATIONHIV/AIDS ASSOCIATED MELANOSIS
IDOPATHIC PIGMENTATIONLAUGIER-HUNZIKER PIGMENTATION
FRECKLE
FRECKLEAsymptomatic, small (1-3 mm), well circumscribed, tan or brown color macule.Sun exposed facial and perioral skinLight skinned, red or light blond haired individualsETIOLOGYDevelopmental in originPolymorphism in MCIR gene.Ch 4q32-q34.( Increase melanin production without concomitant increase in no of melanocytes)
ORAL/LABIAL MELANOTIC MACULE
ORAL/LABIAL MELANOTIC MACULE
Benign pigmented lesion that has no dermal counterpart.Most common oral lesion - melanocytic originEtiology trauma?Females - lower lip gingiva.