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Ibogaine Therapy: Forms and Dose Regimens Howard S. Lotsof, B.F.A., C.M.A. President Dora Weiner Foundation Staten Island, NY http://www.doraweiner.org

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We are motivated with the belief that everyone deserves the opportunity to be free from the chains of addiction and so therefore we make it our goal to make that a possibility for all. Our passion is fueled by our own experience of the miracle that is Ibogaine treatment and through that we are driven to bring this knowledge to all. We have consultants located in Los Angeles and San Diego with our treatment center in Playas, Mexico. We are easily accessible through either phone or email communication, so please don’t hesitate and experience the miracle that is being reborn free of addiction.

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Page 1: Elephant Sunshine

Ibogaine Therapy: Forms and Dose

Regimens

Howard S. Lotsof, B.F.A., C.M.A.President

Dora Weiner FoundationStaten Island, NY

http://www.doraweiner.org

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Forms in Current Use

• Botanical - root bark

• Total alkaloid extract

• purified ibogaine

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Tabernanthe iboga shrub

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Roots contain ibogaine

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Total Alkaloid Extract

Large piece 2cm x 2cm, approx 4 grams

Estimate 15% ibogaineCourtesy Sara Glatt

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Ibogaine HCl

99.4% purity

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All forms have multiple treatment applications1.Chemical use disorders

2.Pain management

3.Psychotherapy

4.Initiatory sessions

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Each form has

1.Different onset

2.Different duration of action

3.And significant diversity across the patient population

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Onset of Effects (min)

020406080

100120140160

HCl Extract

Full EffectOnset

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Period of visuaization (hours)

02468

10121416

HCl Extract

Extended

Visualization

Onset

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Duration of Action (days)

0123456789

10

HCl Extract

Residual

Principal

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Effect on sleep (weeks)

0123456789

10

HCl

Residual

Principal

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Dose and Dose Regimen

1.Single dose

2.Multiple

1.Escalating

2.Deescalating

3.Linear

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All doses are representative. Doses, including single administration doses are determined on a patient by patient basis. The graphs of dose regimens and information that follow should not be used by persons without experience to self-administer or administer to others any dose of ibogaine or total alkaloid extract of Tabernanthe iboga.

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Single dose regimens usually fall between 10mg/kg and 22mg/kg depending on type of therapy offered: opioid dependence, stimulant dependence, psychospiritual, etc. Most doses fall in the 15mg/kg - 20mg/kg dose range to reach full therapeutic effects.

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ibogaine HCl (mg/hour)20mg methadonetotal - 1000mg

350

175 175 175125

050

100150200250300350400

0 h1 h2 h3 h4

HCl

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ibogaine HCl (mg/kg/hour)stimulant therapy

courtesy Eric Taub

2.5

10

32468

10121416

0 h2 h3

HCl

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ibogaine HCl (mg/kg/hour)heroin therapytotal 21.5mg.kg

courtesy Eric Taub

2.5

14

5

2468

10121416

0 1h h12

HCl

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ibogaine HCl (mg/kg/hour)methadone therapy

total 36.5 mg/kgcourtesy Eric Taub

2.5 2.5 2.5 2.5 2.5

12

3 3 3 32468

10121416

013 23 30 34 36 59 68 77 89

100

HCl

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extract (grams/hour)heroin therapytotal 7 grams

courtesy Sara Glatt

3 3

1

0123456

0 12 36 48

Exract

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extract (grams/hour/day)methadone therapy

total 11 gramscourtesy Sara Glatt

3 3

1 1 1 1 1

0123456

0 12 36 d2 d4 d6 d8 d10

Exract

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extract (grams/hour)HCl (mg/hour)

methadone 300mg/daytotal extract 9 grams

total HCl 400mgcourtesy Marc Emery

5.2

3.8

0.1 0.1 0.1 0.10123456

0h72 h96h120h168h192

ExractHCl

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All doses and dose regimens shown or discussed are representative and are not indicated to be provided to any other patient or subject. All doses and dose regimens are made on a patient by patient basis upon knowledge and prior art.