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Effect of Navayasa Rasayana Leha and MedhyaRasayana tablet in the management of Ekkakushta (psoriasis). Clinical study. By: Dr.Rajimunnisa begum.sk P.g scholar ,Dept.of k.c: Guide : Dr.S.Ramalingeswar rao.M.D (Ayu) 16-Dec-14 1 k.C dept

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Effect of Navayasa Rasayana Leha and MedhyaRasayana

tablet in the management of Ekkakushta (psoriasis).Clinical study.

By: Dr.Rajimunnisa begum.sk

P.g scholar ,Dept.of k.c:

Guide : Dr.S.Ramalingeswar rao.M.D (Ayu)

16-Dec-14 1k.C dept

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INTRODUCTION

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EPIDEMIOLOGY

PREVALENCE

MORTALITY &

MORBIDITY

GENDER&AGE

INTERNATIONAL

RANKING

INTERNATIONAL

DISTRIBUTION

c

Causative factors

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CONT………..

What might be the comparison ?

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OBJECTIVES &

CLINICAL PLAN

OBJECTIVES

OF THE STUDY

TO ASSESSES

THE

EFFICACY OF

1.NAVAYASA

RASAYANALEHA

2.MEDHYARASAY

ANA TABLET

CLINICAL

PLAN

3 PATIENTS

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DURATION-3MONTHS

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PARAMETERS

SUBJECTIVE

• Matsyashakala

• Aswedha

• Ruksha

• Kandu

• Daha

• Mandala

• Bahalatva

• Srava

• Unnati

OBJECTIVE

• Diagnosis was supported by

the following clinical tests.

• 1. Candle grease sign

• 2. Auspitz sign

• 3. Koebne phenomena

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CLINICAL PLAN

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•Diagnosis was supported by the

followingclinical tests.

•1. Candle grease sign

•2. Auspitz sign

•3. Koebner phenomen

DIAGNOSTIVC

CRITERIA

• 1. Age- 13-70 years

• 2. Cardinal symptoms of Ekkakushta.

chronicity less than 5yrs

• 3. Positive Signs of Psoriasis like

Auspitz sign, Candle grease sign etc.

INCLUSIVE

CRITERIA

• PATIENTS WITH MAJOR

SYSTEMIC ILLNESS

EXCLUSIVE

CRITERIA

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DISEASE REVIEW

NIDANA,SAMPRAPTHI

PURVARUPA ,RUPA

CHIKITSA

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pathophysiology

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k.C dept 9

• The initiation and maintenance of lesions requires

activated T Lymphocytes

• Drugs suppressing T-cell activity contribute to the

improvement of psoriasis t of psoriasis activity contribute to the improvement of psoriasis

16-Dec-14

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HISTOPATHOLOGY

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Types of Psoriasis

1-Psoriasis Vulgaris(Plaque-type)

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2-Guttate Psoriasis

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2-Guttate Psoriasis

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3-Inverse Psoriasis

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4-Psoriatic erythroderma

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5-Pustular Psoriasis

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6-Sebopsoriasis

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7- Napkin psoriasis

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NAIL CHANGES IN

PSORIASIS

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DRUGREVIEW

• Navayasa Rasayana (5gms bid)

• Leha is taken from the reference found in Chakradatta It has the following ingredients in increasing proportions - Dhatri, Aksha,

Haritaki, Vidanga, Chitraka,

Shuddha Bhallataka, Bakuchi, Loha

• Bhasma, Bhrungraj and Tila Taila

(Q.S). The fine powder of the drugs is to be licked with Tila Taila at the time of drug administration.

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CONT……………

Medhya Rasayana tablet ( 500mg 1 bid)

• Stress is the most crucial factor in onset

and progression of the disease

• Hence, Medhya Rasayana tablet is

Anubhuta Yoga (non-classical

formulation).

• It contains the following drugs in

increasing proportions-

• Vacha, Haritaki, Jatamansi, Jyotishmati,

Yashtimadhu, Shuddha Bhallataka,

Guduchi, Brahmi and Shankhpushphi.

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Probable mode of action of

drugs in N.R leha

• Actions

• Immunomodulatory

• Antioxidant

• Adaptogenic

• Wound Healing

• Anti-inflammatory

• Anti-arthritic

• Antistress

• Drugs

• Amalaki, Haritaki, Bakuchi

• Amalaki, Haritaki,

Bhallataka

• Amalaki, Haritaki

• Haritaki,Amalaki

Bhallataka, Bakuchi,

Bhrungraj

• Bhallataka

• Bhallataka

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Pharmacologically proven

actions of drugs of M.T

Actions

• Sedative

• CNS depressant

• Anti-inflammatory

• Immunomodulatory

Antioxidant

• Antistress

• Adaptogenic

• Nootropic

• Drugs

• Sedative Vacha, Jyotishmati,

Shankpushpi

• Vacha, Jatamansi

• Jyotishmati, Yashtimadhu,

• Guduchi, Bhallataka

Yashtimadhu, Guduchi, Haritaki

Yashtimadhu, Brahmi, Haritaki

Yashtimadhu, Guduchi

Yashtimadhu, Guduchi, Haritaki

• Yashtimadhu, Guduchi, Brahmi,

Shankhpushpi

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RESULTS

GRADING

Matsya shakalalopam .asweda .daha, Ruksha other signs

PRESENT--------2

MPROVED--------1

ABSENT---------0

Mandala

NORMAL SKIN –0

FAINT OR NEAR TO NORMAL—1

Blanching + redness-2

No blanching + redness—3

Red color + subcutaneous---4

Kandu

No itching-------0

Mild itching------------1

Severe itching----------2

Very severe itching----3

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Statistical analysis of results

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SYMPTOMS & SIGNS B.T SCORE A.T SCORE

Matsya shakala 06 4

Mandala 12 8

Rukshas 06 2

Kandu 12 8

Daha 05 3

Asweda 04 2

Srava 8 4

Bahalatwa 7 3

Auspitz sign 6 3

Candle grease sign 5 3

Koebne phenomena 5 2

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Results No. of Patients Percentage

Good/complete

relief

2 75%

Moderate relief 1 25%

Poor/No relief 0 0

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Before & After

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Before & After

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DISCUSSION

• Navayasa rasayanaleha has provided better relief

• in symptom of Matsyashakala,

Asvedanam,

• Rukshata, Koebner phenomenon and

Kandu

• On the other hand comparatively better improvement in Mandala,

• candle grease sign and Daha.

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CONCLUSION

Stress may lead to early onset of disease (maximum patients-21-30 years) and early recurrence.

Virrudhaashana is one of the predominant Nidana which is also described by Acharya Charaka as cause of

Ninditavyadhies

one among which is Kushtaroga.

Maximum patients were depressed/ anxious- which clearly shows the psychosomatic nature of the disease.

Family history was positive in some of the patients, suggesting a genetic cause of the disease.

In the present study, it may be inferred that people of Vata-Kapha Prakruti may be more susceptible to Psoriasis. k.C dept

34

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References

• VaraBehl PN, Agarval A and Shrivastava Govinda:Practice of Dermatology.

• Cha Chi 7:21,39

• Su.Chi 9: 43,68

• Chakradatta :Kusta roga prakarana

• A.s 21:9

• A.h 19:31,32

• Etc...........

• 1999)

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