Effect of High-Grade Disease on Colon Cancer Outcomes

04/15/23 10th Annual Academic Surgical Congress, February 3-5 2015, Las Vegas, NV07 - QuickShot: Clinical Research - Oncology

Ramzi Amri, MD1,2 Liliana G Bordeianou, MD, MPH1,2 Patricia Sylla, MD1,2 and David L Berger, MD 1,2

1 Massachusetts General Hospital, Division of General and Gastrointestinal Surgery.2 Harvard Medical School, Department of Surgery.

Disclosures: none

Introduction

• Tumor grade is a cardinal surgical pathological characteristic of any malignancy.

• High-grade disease invariably has a negative impact on the eventual outcomes of the concerned malignancy.

• We aimed to measure the magnitude of its influence as well as its stage-independent effect in colon cancer.

Methods

• Included: • Surgical colon cancer patients at MGH 2004-2011 with known

disease grade (n=961)

• Comparison• Baseline pathology:

• RR of nodal and distant metastasis• Outcomes:

• Risk of recurrence, • Overall and disease-specific mortality

• Statistical analysis• Ordinal: χ2, continuous: Mann Whitney U• Multivariate: logistic regression, AJCC-adjusted

Results

Conclusions

• High-grade disease on baseline colon cancer surgical pathology is associated with a considerably higher rate of nodal and distant metastasis.

• Colon cancer-related mortality doubles for patients with high-grade disease.

• All of these findings were shown to be independent of baseline staging.

High tumor grade is a stage-independent factor greatly influencing colon cancer outcomes and mortality.

Questions?