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7 – 8 March 2013, London, United KingdoM
ectriMSFocused Workshop
2013
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ECTRIMS Committees
Executive Committee
B. Hemmer Munich, DE C. Lubetzki Paris, FR D. Miller London, UK Workshop Chair & ECTRIMS Secretary X. Montalban Barcelona, ES ECTRIMS Vice President T. Olsson Stockholm, SE P. Soelberg Sørensen Copenhagen, DK ECTRIMS Treasurer M. Trojano Bari, IT ECTRIMS President
Focused Workshop Organizers
F. Fazekas Graz, AT D. Miller London, UK Workshop Chair & ECTRIMS Secretary X. Montalban Barcelona, ES ECTRIMS Vice President S. Reingold Salisbury, US Workshop Advisor
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Welcome to London
Welcome to the ECTRIMS Focused Workshop
“Pregnancy and Hormonal Factors in MS”
London, 7-8 March 2013
Dear Participants
A warm welcome to you all, as participants in the first ever ECTRIMS focused workshop. The
workshop is one of several new initiatives being undertaken by ECTRIMS this year, in line with our
mission “To facilitate communication, create synergies, and promote and enhance research and
learning among professionals for the ultimate benefit of people affected by MS.”
Pregnancy in MS is of course a topic of major and increasing clinical importance, especially with an
expanding range and complexity of disease modifying treatments being used to treat patients who
may also wish to have children. There is also increasing understanding of the relationship of
hormonal factors to the course of MS. It is therefore timely to hold this workshop, which brings
together international experts in the field. The workshop proceedings will provide the basis of a
state-of-art review to be submitted for publication in an appropriate journal.
We hope that you will enjoy the scientific meeting - and being in a fascinating part of London. The
meeting venue is in the National Hospital for Neurology and Neurosurgery, Queen Square, where
there has been a 150-year-long interest in neurology and neuroscience. The workshop dinner on
Thursday evening will be held a short walk away at the Foundling Museum, whose historical origins
seem rather apt for our workshop theme.
David Miller Xavier Montalban Franz Fazekas
Workshop Chair Workshop Organizer Workshop Organizer
Stephen Reingold Maria Trojano
Workshop Advisor ECTRIMS President
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Workshop Programme
Thursday, 7 March 2013
08.30-09.40 Session 1: Meeting overview and experimental background
Chair: M. Trojano (Bari, IT)
08.30-08.35 Welcome and meeting logistics D. Miller (London, UK)
08.35-08.55 Historical background and meeting aims Overview of the understanding and management of pregnancy and hormonal factors in MS
X. Montalban (Barcelona, SP)
08.55-09.25 Hormonal factors in experimental models of MS and related disorders What do we know, what has the contribution of EAE been to the understanding of MS?
H. Offner (Portland, US)
09.25-09.40 Discussion
09.40-10.10 Coffee Break
10.10-12.05 Session 2: Preparing for Pregnancy with MS
Chair: X. Montalban (Barcelona, ES)
10.10-10.40 Risk counseling for parents with MS How to guide parents about risks of pregnancy to the mother with MS, complications of MS for child-rearing, and risk of MS in off-spring
D. Sadovnick (Vancouver, CA)
10.40-10.55 Discussion
10.55-11.15 Fertility treatments and risk of MS relapses What we know about contemporary fertility treatment and impact on MS disease course in women
K. Hellwig (Bochum, DE)
11.15-11.30 Discussion
11.30-11.50 Effect of disease modifying therapies (DMTs) on fertility of women and men with MS, effect of DMTs on foetal viability Does prior therapy with DMTs affect the development and viability of a foetus?
M. Clanet (Toulouse, FR)
11.50-12.05 Discussion
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13.00-14.55
Session 3: Impact of Pregnancy on MS Disease Course
Chair: T. Olsson (Stockholm, SE)
13.00-13.30 Short-term (relapse risk) and long-term (progression of disability) impact of pregnancy in MS Current data on change in disease relapse characteristics during pregnancy and post-partum; do single (or multiple) pregnancies have an impact on long-term outcomes?
C. Confavreux (Lyon, FR)
13.30-13.45 Discussion
13.45-14.05 MRI during pregnancy and post-partum Are changes in MS disease course during pregnancy and post-partum reflected in pathology detected by MRI?
F. Fazekas (Graz, AT)
14.05-14.20 Discussion
14.20-14.40 Pregnancy and NMO-spectrum disorders Pregnancy outcomes in NMO-spectrum disorders and whether it differs from MS
M. Leite (Oxford, UK)
14.40-14.55 Discussion
14.55-15.25 Coffee Break
15.25-17.55 Session 4: Treatment During Pregnancy
Chair: F. Fazekas (Graz, AT)
15.25-15.45 When and how to treat an MS relapse during pregnancy Best current relapse management strategies Data from clinical practice and clinical trials
P. Soelberg Sørensen (Copenhagen, DK)
15.45-16.00 Discussion
16.00-16.30 Older disease modifying treatment during pregnancy Outcomes f rom clinical trials and in clinical practice; how to manage
M. Sandberg-Wollheim (Lund, SE)
16.30-16.45 Discussion
12.05-13.00
Lunch Break
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16.45-17.05
Newer disease modifying treatments during pregnancy Outcomes from clinical trials and in clinical practice; how to manage
R. Gold (Bochum, DE)
17.05-17.20
Discussion
17.20-17.40
Symptomatic management during pregnancy Data from clinical trials and practice
M. Hutchinson (Dublin, IR)
17.40-17.55
Discussion
19.00 - 22.00
Workshop Dinner at the Foundling Museum
Friday, 8 March 2013
08.30-09.30 Session 5: Panel Discussion
Facilitator: S. Reingold (Salisbury, US)
What can we recommend as the best ways to manage MS during pregnancy, for both the health of the mother and of the foetus/new-born? What is data driven, what is speculation? What is needed to provide missing data?
Panel Members E. Havrdova (Prague, CZ) L. Kappos (Basel, CH) A. Miller (New York, US) S. Tennebaum (Buenos Aires, AR) E. Waubant (San Francisco, US)
09.30-10.50 Session 6: Delivery and Beyond
Chair: C. Lubetzki (Paris, FR)
09.30-10.00 Obstetric management for women with MS Case studies and best practices
D. Williams (London, UK)
10.00-10.15 Discussion
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10.15-10.35
Delivery and neonatal outcomes Problems associated with delivery for women with MS; considerations for neonatal health and management
H. Tremlett (Vancouver, CA)
10.35-10.50
Discussion
10.50-11.20
Coffee Break
11.20 – 12.30
Session 6 (continued) Chair: C. Lubetzki (Paris, FR)
11.20-11.40 Breast feeding and MS Impact of breast feeding on disease course; impact of MS disease modifying and symptomatic therapies on breast milk
A. Langer-Gould (California, US)
11.40-11.55 Discussion
11.55-12.15 Geographical variations in gender ratio trends over time in MS The utility of international MS registries for gender issues
M. Trojano (Bari, IT)
12.15-12.30 Discussion
12.30-13.30 Lunch Break
13.30-15.45 Session 7: Non-Pregnancy-Related Hormonal Factors and MS Disease Course
Chair: P. Soelberg Sørensen (Copenhagen, DK)
13.30-13.50 Menopause and MS Effect of menopause on MS disease course and therapeutic implications
R. Bove (Boston, US)
13.50-14.05 Discussion
14.05-14.35 Experimental basis, current status and future prospects for repurposing hormones as DMTs for MS Oestriol and testosterone clinical trials in MS
R. Voskuhl (California, US)
14.35-14.40 Discussion
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14.40-15.10
Impact of an add-on oral contraceptive to beta interferon in MS Does oral contraception affect MS?
C. Pozzilli (Rome, IT)
15.10-15.25 Discussion
15.25-15.45 Summing up What have we learned, where are we headed?
D. Miller (London, UK)
15.45 Meeting end
Information for Speakers and Chairs
Holding a presentation The lecture theatre is equipped with a lectern at which you can hold your presentation. A projector and screen are at your disposal to display your Power Point presentation. Please bring your presentation on an USB stick or external hard drive and hand it to the technician in the lecture theatre. Please note that no corrections can be made to presentations in the room. Chairing a session Please note that no chair table will be available on stage. When chairing a session, we kindly ask you to sit in the first row of the theatre and proceed to the lectern on stage when introducing the next speaker. There will be a few places reserved in the first row.
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The Foundling Museum
The official Workshop Dinner will take place at London’s Foundling Museum. The evening will commence with a light aperitif which is followed by a seated dinner in the museum’s Picture Gallery room.
Please find the details of the evening below:
Date: Thursday, 7 March 2013
Time: 19.00 – 22.00h
Address: The Foundling Museum 40 Brunswick Square London WC1N 1AZ
The Foundling Museum tells the story of the Foundling Hospital, Britain's first home for abandoned children. It examines the work of the Foundling Hospital's founder Thomas Coram, various artists and also illustrates how the Foundling Hospital's charity work for children still carries on today. During the evening you will be able to wander around the museum and view the entire collection.
A reservation has been made at the museum for you, if you did not notify the organizers otherwise. Should you not be able to join us, we kindly ask you to inform us. If you wish to bring an accompanying person, please contact the organizer (upon availability only). The Foundling Museum is located within 5 minutes walking distance from the Russell Hotel. Please make your own way to the museum. For details, please see the location map on page 9.
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Location Map
Accommodation Lecture Theatre
Hotel Russell UCL Institute of Neurology Russell Square 33 Queen Square London WC1B 5BE London WC1N 3BG United Kingdom United Kingdom Tel: +44 207 837 6470 Access: use main entrance, walk through the patient room and take the stairs to level -1. Workshop Dinner Administrative Secretariat
The Foundling Museum ECTRIMS Focused Workshop 40 Brunswick Square Congrex Switzerland Ltd London WC1N 1AZ Peter Merian-Strasse 80 United Kingdom 4002 Basel / Switzerland Tel: +41 61 686 7777
E-mail: [email protected]
Hotel Russell
Lecture Theatre
Foundling Museum
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Workshop Participants
Surname Name City Country Email
Amato Maria Pia Florence IT [email protected]
Bove Riley Boston US [email protected]
Butzkueven Helmut Melbourne AUS [email protected]
Chitnis Tanuja Boston US [email protected]
Ciccarelli Olga London UK [email protected]
Clanet Michel Toulouse FR [email protected]
Confavreux Christian Lyon FR [email protected]
d’Hooghe Marie Melsbroek BE [email protected]
Dadalti Fragoso Yara Santos BR [email protected]
Fazekas Franz Graz AT [email protected]
Gold Ralf Bochum DE [email protected]
Havrdova Eva Prague CZ [email protected]
Hellwig Kerstin Bochum DE [email protected]
Hutchinson Michael Dublin IR [email protected]
Kappos Ludwig Basel CH [email protected]
Langer-Gould Annette California US [email protected]
Leite Maria Isobel Oxford UK [email protected]
Lubetzki Catherine Paris FR [email protected]
Mason Debbie Christchurch NZ [email protected]
McCombe Pamela Brisbane AUS [email protected]
Miller David London UK [email protected]
Miller Aaron New York US [email protected]
Montalban Xavier Barcelona ES [email protected]
Offner Halina Portland US [email protected]
Olsson Tomas Stockholm SE [email protected]
Pozzilli Carlo Rome IT [email protected]
Reingold Stephen Salisbury US [email protected]
Sadovnick Dessa Vancouver CA [email protected]
Sandberg-Wollheim Magnhild Lund SE [email protected]
Sellebjerg Finn Copenhagen DK [email protected]
Soelberg Sorensen Per Copenhagen DK [email protected]
Tenembaum Silvia Buenos AiresAR [email protected]
Tintore Mar Barcelona ES [email protected]
Tremlett Helen Vancouver CA [email protected]
Trojano Maria Bari IT [email protected]
Voskuhl Rhonda California US [email protected]
Waubant Emmanuelle San FranciscoUS [email protected]
Williams David London UK [email protected]
