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June 2011

INNOVATING

in BIOFUNCTIONALISM

June 2011

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June 2011

About New Migrasin®

Other Products

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June 2011

• In addition to a low histamine diet, DAO can be supplemented by a new dietary food supplement MIGRASIN®.

• The natural enzyme rich protein is encapsulated in an acid-resistant matrix to pass the stomach and activity is released directly in the intestine

• The additional DAO increases histamine-degradation in the intestine within 20 min after intake of the capsules and leads to a significant reduction of symptoms.

NEW THERAPY - Migrasin

About Migrasin

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June 2011

MIGRATEST® is a test kit to measure in vitro the level of DAO enzyme activity in blood.

A low level of DAO hinders the adequate metabolism of histamine. The excessive accumulation of histamine can trigger migraine.

Other Products

Migratest® - Diagnosis

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June 2011

MIGRACALM® is a biofunctional device that applies controlled pressure on the point in the temples where most of the pain is focused, producing a sensation of relief without adverse effects.

Other Products

Migracalm® - Palliative device

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June 2011

1.- Déficit de DAO como posible desencadenante de migraña. Estudio Migradao. Mayo de 2010, Jornada Internacional de Sensibilización sobre la Migraña. Congreso de los Diputados de España1.C. Vidal, Catedrática de Nutrición y Bromatología de la Universidad de Barcelona, 2.F. Titus, Miembro de Honor de la Sociedad Española de Neurología, 3. Asociación Española de Pacientes con Cefalea (AEPAC), 4.- Dpt. Epidemiología del Colegio de Farmacéuticos de Barcelona.2.- Supplementation of enteric coated Diamine Oxidase improves intestinal degradation of food-born biogenic amines in case of histamine intolerance.2010 - March, 6th Annual Conference of the ENA in Vienna. A. Missbichler1, I. Mayer1, C. Pongracz2, F. Gabor3 and P. Komericki 1 Sciotec Diagnostic Technologies, Tulln, Austria. 2 Dept. of Nutritional Sciences, University of Vienna, Austria 3 Dept. of Pharmaceutical echnology & Biopharmaceutics, University of Vienna, Austria 4 Dept. of environmental Dermatology, Medical University of Graz, Austria. 3.- Histamine and histamine intolerance. 2007 - The American Journal of Clinical NutritionLaura Maintz1 and Natalija Novak1, 1 Department of Dermatology and Allergology, University of Bonn, Germany. 4.- Effects of histamine and diamine oxidase activities on pregnancy: a critical review. 2008 - May 22, European Society of Human Reproduction and Embryology.Laura Maintz1, Verena Schwarzer2, Thomas Bieber1, Katrin van der Ven2 and Natalija Novak, 1 Department of Dermatology and Allergology, University of Bonn, Germany., 2 Department of Obstetrics and Gynaecology, University of Bonn, Germany 5.- Evidence for a reduced histamine degradation capacity in a subgroup of patients with atopic eczema. 2005 - November 29, The Journal of Allergy and Clinical ImmunologyLaura Maintz, MDa - Said Benfadala, Jean-Pierre Allam, MDa – Tobias Hagemann, MDa – Rolf Fimmers, PhDb and Natalija Novak, MDa Bonn, Germany. a The Department of Dermatology, University of Bonn. b The Department of Medical Biometry, Informatics and Epidemiology, University of Bonn. 6.- Histamine intolerance: a metabolic disease? 2009 - December 12, Birkhäuser Verlag, Basel/Switzerland 2009H.G. Schwelberger, 1 Molecular Biology Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck, Austria.

Scientific background

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7.- Effectiveness of a prolonged compression of scalp arteries on migraine attacks. June 2006 -Journal of Neurology. Volume 253, number 6 Prof. Carlo Cianchetti & Prof. Jousef Hmaidan. University dpt. Neurosciencies- Cagliari (Italy)8.- Compression of Superficial Temporal Arteries by a Handmade Device: A Simple Way to Block or attenuate Migraine Attacks in Children and Adolescents. June 2009 – Journal Child Neurology, Volume 25, pp 67-70. Prof. Giussepina Ledda. University dpt. Neuroseciencies – Cagriari (Italy)9.- Treatment of migraine attacks by compression of temporal superficial arteries using a device. April 2009 -Journal of Neurology. Medical Science Monitor – New York CR 185-8 Prof. Carlo Cianchetti, Prof. Tiziana Pisano, Prof. Elisabeth Cianchetti & Prof. Giussepina Ledda University dpt. Neurosciencies – Cagliari (Italy)10.-Legal-medical and neurological assessment of its informative distribution as a medical device used to relieve migraines.  May 2008 - Autonomous University of Barcelona-Valle Hebron University Hospital. Ref. 18/08Prof. Manuel Rodriguez Pazos & Prof. Manuel Romacho Romero. Schhol of Medicine. Autonomous University of Barcelona University Hospital Valle Hebrón.

Scientific background (2)

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June 2011

Thank you for your attention