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Lucine Health Sciences, Inc. | Hormones Matter
Deconstructing Modern Illness
Idiopathic or Iatrogenic?
Lucine Health Sciences, Inc. | Hormones Matter
You did then what you knew how to do,
And when you knew better,
You did better. Maya Angelou
Lucine Health Sciences, Inc. | Hormones Matter
Core PrinciplesoPregnancy is an opportunity to break cycles of bad health oReproduction should be viewed from a much broader and longer
perspective. o Dad’s health matterso At least one year pre-conception – postpartum yearo Transgenerational – can’t undue sins of our parents and grandparents,
but we can protect our children and grandchildreno Everything is connected – a more holistic and systems approach
to health oHealth is complicated, disease is individual, we have a lot to learn
o If the symptoms don’t fit Dx categories, trust your gut and figure out what is wrong
Lucine Health Sciences, Inc. | Hormones Matter
IntroductionWho, what and why?
Lucine Health Sciences, Inc. | Hormones Matter
Who am I? oMom, wife, jock, researcher, writer, women’s health advocate
oBackground in maternal health and hormones
oMore recently, medication adverse reactions, nutrition and mitochondrial damage
Lucine Health Sciences, Inc. | Hormones Matter
What I Do Officially
Lucine Health Sciences, Inc. | Hormones Matter
What I Really Doo150,000+ monthly
views
o1200+ articles and growing
o150 guest contributors/writers
• 18 PhDs, 5 MDs, 2 DPTs
oThousands of comments
Cause trouble.
Lucine Health Sciences, Inc. | Hormones Matter
Listen and Learn
Lucine Health Sciences, Inc. | Hormones Matter
And Try to Untangle
The untanglible.
Lucine Health Sciences, Inc. | Hormones Matter
Lucine Health Sciences, Inc. | Hormones Matter
What I Have LearnedoEnvironment matters
• More than genetics
oHealth and disease are both sudden and slow
• Thresholds and tipping points
oAll about the mitochondria • Mitochondria determine everything
Everything we think we know is wrong.
Lucine Health Sciences, Inc. | Hormones Matter
Let the Deconstruction Begin.Do we know what we think we know?
Lucine Health Sciences, Inc. | Hormones Matter
“There is often something sinister about familiar concepts. The more familiar or ‘natural’ they appear, the less we
wonder what they mean; but because they are widespread and well-known, we tend to act as if we know what we
mean when we use them.” Devisch, I. & Murray, S., 2009. doi:10.1111/j.1365-2753.2009.01232.x
Just because it is familiar
Doesn’t make it right or true.
Lucine Health Sciences, Inc. | Hormones Matter
Framing the conversation
Lucine Health Sciences, Inc. | Hormones Matter
Implications of idiopathyoEverything we don’t understand is idiopathic
• Illness of unknown origin is random – we cannot know the causes
oWe have no responsibility for randomness• Choices/behaviors don’t matter
• No need to study
• Can only treat but never cure or prevent
Lucine Health Sciences, Inc. | Hormones Matter
Cancer is random?
“These results suggest that only a third of the variation in cancer risk among tissues is attributable to environmental factors or inherited predispositions. The majority is due to
‘bad luck,’ that is, random mutations arising during DNA replication in normal, noncancerous stem cells.”
Tomasetti & Vogelstein 2015. Science, Vol. 347, Issue 6217, pp. 78-81DOI: 10.1126/science.1260825
Lucine Health Sciences, Inc. | Hormones Matter
Randomness absolves us of responsibility
Lucine Health Sciences, Inc. | Hormones Matter
Randomness means we can ignore things like this
Lucine Health Sciences, Inc. | Hormones Matter
And this… o Pharmaceutical and
environmental chemicals rearrange MLL Gene via topoisomerase inhibition
• Glyphosate (and other herbicides/pesticides), fluoroquinolone antibiotics, hormonal contraceptives, HRT and other drugs
o Topoisomerases manage nDNA, mtDNA replication and repair.
MLL- related leukemias are not heritable, not found in germlines, but a result of exposure
in utero (infant leukemia) or during later child development (pediatric leukemia).
Lucine Health Sciences, Inc. | Hormones Matter
25-75% of the symptoms reported in outpatient settings are considered
medically unexplained.
How much of medicine is idiopathic?
Source: Smith, R.C. and Dwamena, F.C., 2007. Classification and diagnosis of patients with medically unexplained symptoms. Journal of general internal medicine, 22(5), pp.685-691.
Lucine Health Sciences, Inc. | Hormones Matter
Idiopathy exists, not because this stuff is unknowable, but rather, because we
choose not to look.
Source: Smith, R.C. and Dwamena, F.C., 2007. Classification and diagnosis of patients with medically unexplained symptoms. Journal of general internal medicine, 22(5), pp.685-691.
Lucine Health Sciences, Inc. | Hormones Matter
70%
OF OB/GYN CLINCAL PRACTICE GUIDELINES
NOT BASED ON EVIDENCE
For women…
Idiopathy runs rampant.
Lucine Health Sciences, Inc. | Hormones Matter
50%
OF MEDICAL INTERVENTIONS UNPROVEN
ONLY 35% KNOWN TO BE BENEFICIAL
Source: BMJ Clinical Evidence, http://clinicalevidence.bmj.com/x/set/static/cms/efficacy-categorisations.html
For medicine in general
We really don’t know what we think we know.
Lucine Health Sciences, Inc. | Hormones Matter
Source: BMJ Clinical Evidence, http://clinicalevidence.bmj.com/x/set/static/cms/efficacy-categorisations.html
Lucine Health Sciences, Inc. | Hormones Matter
Medication nationMayo Clinic Reportso70% adults take
prescription medications chronically
o50% take 2 or more meds
o20% take 5 or more meds
“Before the SSRIs, drugs were poisons that came with risks. Now they are fertilizers to be used as widely as possible, being given in ever larger amounts to children and the elderly - the only risks the authorities can see it would seem stem from not using enough of them.”
David Healy
Lucine Health Sciences, Inc. | Hormones Matter
If only 50% of medications have sufficient evidence of efficacy, what happens when we
combine multiple medications? Efficacy?Safety?
Lucine Health Sciences, Inc. | Hormones Matter
Can we really know what illnesses chronic polypharmacy use might spur if we’ve never
bothered to ask the question?
Lucine Health Sciences, Inc. | Hormones Matter
If 25-75% of symptoms can be considered medically unexplained, how certain are we of
our current diagnostics?
Lucine Health Sciences, Inc. | Hormones Matter
Maybe idiopathic is really iatrogenic?
Lucine Health Sciences, Inc. | Hormones Matter
The problem of iatrogenesiso3rd leading cause of death in hospitalized patients
• Estimated at 200,000-400,000 patients annually• 6.8% of cases were attributable to an adverse drug reaction 1964-
1995
oFDA/ADR data (2011) • 2.1 to 2.7 million Americans suffer from an serious adverse drug
reaction annually • 128,000 result in death
James, J.T., 2013. A new, evidence-based estimate of patient harms associated with hospital care. Journal of patient safety, 9(3), pp.122-128; Null, G., Dean, C., Feldman, M. and Rasio, D., 2005. Death by medicine. Journal of Orthomolecular Medicine, 20(1), pp.21-34; Makary, M.A. and Daniel, M., 2016. Medical error—the third leading
cause of death in the US. Bmj, 353, p.i2139; Stokowski, L.A., 2016. Who believes that medical error is the third leading cause of hospital deaths. Medscape, May, 26Light, D.W., Lexchin, J. and Darrow, J.J., 2013. Institutional corruption of pharmaceuticals and the myth of safe and effective drugs; Light, D.W., Lexchin, J. and Darrow,
J.J., 2013. Institutional corruption of pharmaceuticals and the myth of safe and effective drugs..
Even as currently defined.
Lucine Health Sciences, Inc. | Hormones Matter
Implications of iatrogenesisoPresumes we know the scope of effects for a given
treatment• If 50% of treatments unproven, do we really know the scope
of effects? • Even when tested, often only tested in isolation, in men, with
little application to real world uses
oAnything we don’t know is random or idiopathic
oWe have no responsibility for randomness
oNo need to study
Lucine Health Sciences, Inc. | Hormones Matter
Lucine Health Sciences, Inc. | Hormones Matter
Deconstructing Women’s HealthWhere idiopathy, iatrogenesis and willful ignorance intersect.
Lucine Health Sciences, Inc. | Hormones Matter
Women use more medications than men
A review of insurance records for a 1 year period in 2010 showed: • Women = 5 prescriptions
• Men = 3.7 prescriptions
• 68% of women versus 59% of men had one prescription for at least one medication for a chronic or acute condition during the study period.
Women’s Health 2012: The 20th Annual Congress; https://www.washingtonpost.com/blogs/the-checkup/post/women-prescribed-more-drugs-than-men-but-dont-always-take-them-research-shows/2010/12/20/gIQAJm5hNS_blog.html?utm_term=.f913aa9f54a6
Lucine Health Sciences, Inc. | Hormones Matter
During Pregnancyo80% of women take at least
one medication during pregnancy
o~30% take 4 or more medications during pregnancy
• 60% increase in medication use during pregnancy in 30 years
Lucine Health Sciences, Inc. | Hormones Matter
Most of these drugs were never safety tested with womenoNo testing on drugs approved before 1993
oGuidelines not enacted until 1998
Lucine Health Sciences, Inc. | Hormones Matter
Even after the regulationsoPer the GAO (2000)
• 52% of clinical trial participants women, mostly later phases
• Only 22% of early phase trials, where safety and dosing determined
oPer the IOM OWH (2010)• Much the same
Lucine Health Sciences, Inc. | Hormones Matter
Here’s the thing
Even though women are now allowed in clinical trials, there is no requirement for researchers/drug companies to determine
whether women react differently than men to a medication before it is approved.
So they don’t.
Lucine Health Sciences, Inc. | Hormones Matter
As a resultoWomen suffer significantly more frequent and more
severe adverse drug events
oFew notice because none of these reactions were documented in the first place
Cardiovascular disease is the most common cause of death in American women and in recently recalled medications for heart
disease there were disproportionately higher fatalities and serious adverse events in women than in men.
– Cochrane Reports
Idiopathic or iatrogenic?
Lucine Health Sciences, Inc. | Hormones Matter
Ethical conundrumoTesting on women might impair reproductive
capacity
oMedication use during pregnancy might harm the fetus
oBUT women use medications across the lifespan and during pregnancy
• If we’re not going to test, should we really be recommending these medications to women?
Lucine Health Sciences, Inc. | Hormones Matter
Possible solutionsoAnimal testing
oUse meds only sparingly in pregnant women
oIntense post market surveillance
Might temper some of the risks
Lucine Health Sciences, Inc. | Hormones Matter
Lucine Health Sciences, Inc. | Hormones Matter
What do human females and male rodents have in common?
Apparently, they are equivalent.
Lucine Health Sciences, Inc. | Hormones Matter
Source: Beery, A., & Zucker, I. (2011). Sex Bias in Neuroscience and Biomedical Research. Neuroscience and Biobehavioral Reviews, 35 (3), 565-572.; https://genderedinnovations.stanford.edu/case-studies/animals.html
Lucine Health Sciences, Inc. | Hormones Matter
No one considered
Until 2014!
that males and females might be different
Lucine Health Sciences, Inc. | Hormones Matter
Perhaps it’s not about ethics at all, but rather, expediency.
Lucine Health Sciences, Inc. | Hormones Matter
Long, inglorious history • Used from 1957-1961 as
anti-emetic, hyperemesis mostly in Europe
• 2000-100,000 children born with severely malformed limbs
• FDA denied approval
Thalidomide -prescribed for morning sickness Of medicating women.
Lucine Health Sciences, Inc. | Hormones Matter
Diethylstilbestrol (DES) – to prevent miscarriage At least 3 generations affected: sons, daughters
and grandchildren
Without research• 5-10 million women from 1940-
1970s• FDA approved, no research• Late 50s-60s first research:
increased risk of miscarriage• Multi-generational damage
(cancer, organ malformation, more)
• Used in farm animals• Caused cancer in farm hands,
miscarriage and illness in animals
• Banned in 1958 in animals• Still used in women for another
20+ years
Lucine Health Sciences, Inc. | Hormones Matter
Or dubious research
Lucine Health Sciences, Inc. | Hormones Matter
For male satisfaction
Lucine Health Sciences, Inc. | Hormones Matter
And for social reasons
1959-1970s physicians and researchers from the Royal Children’s
Hospital and the University of Melbourne gave adolescent girls of
tall stature DES to stunt growth. The rationale behind treating tall girls
was so they could do ballet, buy clothes more easily, and find
boyfriends and husbands.
Source: Lee & Howell, Tall girls: the social shaping of a medical therapy. Arch Pediatr Adolesc Med. 2006 Oct;160(10):1035-9.
When Being a Tall Girl was a Medical Condition: DES and the Tall Girls
Lucine Health Sciences, Inc. | Hormones Matter
And then covering it up
Used as a pregnancy test 1960s-70s
Equivalent to 13 morning after pills or 157 oral contraceptive pills
January 1975, Dr William Inman, principal medical officer for the British Government, had found that women who took a hormone pregnancy test “had a five-to-one risk of giving birth to a child with malformations”.
Dr Inman wrote to Primodos’s German manufacturer, Schering, so the firm could “take measures to avoid medico-legal problems”, rather than recall the drug.
A later document explains that Dr Inman destroyed the materials on which his findings were based, “to prevent individual claims being based on his material”.
Source: http://www.telegraph.co.uk/news/2017/03/18/new-evidence-claims-against-pregnancy-test-drugs-linked-birth/
Lucine Health Sciences, Inc. | Hormones Matter
It’s worse for pregnant women
• There are no data for [insert vaccine] administered to pregnant women to inform vaccine-associated Package insert
• Available data on [insert vaccine] administered to pregnant women are insufficient to inform vaccine-associated risks in pregnancy.
• There were no developmental toxicity studies of [insert vaccine] performed in animals.
• It is not known whether [insert vaccine] is excreted in human milk.
• Data are not available to assess the effects of on the breastfed infant or on milk production/excretion.
Despite all marketing to the contrary, most
medications and vaccines were never tested for use during
pregnancy.
Source: Package inserts
Lucine Health Sciences, Inc. | Hormones Matter
We never learned
With little evidence of safety and efficacy
We continue to drug women
Lucine Health Sciences, Inc. | Hormones Matter
And for childrenoOnly 10-20% of
medications for pediatric use have been tested in children
oPharmacokinetic and pharmacodynamic research developed in adult males
oRampant off-label for kids, particularly kids in foster care
Sources: Conroy, S., McIntyre, J., Choonara, I., & Stephenson, T. (2000). Drug trials in children: problems and the way forward. British Journal of Clinical Pharmacology, 49(2), 93–97. http://doi.org/10.1046/j.1365-2125.2000.00125.x ; FDA, https://www.fda.gov/Drugs/ResourcesForYou/Consumers/ucm143565.htm;
http://pharmaceuticalcommerce.com/brand-marketing-communications/pediatric-drug-market-finds-its-own-pathway/
“In the absence of rigorous pediatric clinical trial data, physicians are forced to act as if
children are just ‘small adults’ with a smaller weight, and then interpret the adult data to
adjust the dose. But statistically, we know that approach only works in 6% of the cases.”
Lucine Health Sciences, Inc. | Hormones Matter
Lucine Health Sciences, Inc. | Hormones Matter
We’re addictedPsychotropics prescribed in the US o 274,000 infants (0-1 year
olds)o 370,000 toddlers (1-3 year
olds)“Prescriptions of powerful antipsychotics such as Risperdal for
infants and very young children have also sharply risen. Office visits for
childhood bipolar disorder have risen 40-fold over the past decade in the
U.S.” To solving problems with pills and looking away when problems arise.
Lucine Health Sciences, Inc. | Hormones Matter
If drugs are not tested in women or children and thus, their effects in women are unknown, they can easily be disregarded
and labeled as idiopathic. If they are idiopathic, rather than iatrogenic, there is no need
to investigate or even acknowledge side effects as real. For all intents and purposes, they simply do not exist.
Lucine Health Sciences, Inc. | Hormones Matter
For example o Lupron – GnRHa
• Chemically castrates
oDeveloped for male prostate cancer
• Tested on 6 healthy men
• One low dose for a drug to be used repeatedly and chronically at higher doses
oApproved for
• Women with endometriosis, fibroids, heavy bleeding
• IVF
• Children with precocious puberty, gender dysphoria
Lucine Health Sciences, Inc. | Hormones Matter
Considered perfectly safe by many practitioners
• No recognition chemical castration might cause problems
• Depletes gonadal hormones
• Hormones have receptors everywhere and are involved with a myriad of functions beyond reproduction
• With very little research pre – or post-market, symptoms are considered idiopathic or hysteric.
Lucine Health Sciences, Inc. | Hormones Matter
It’s not safe
Lupron damages the mitochondria, perhaps irrevocably.
Lucine Health Sciences, Inc. | Hormones Matter
How bad is it?
Really bad.
Lucine Health Sciences, Inc. | Hormones Matter
Because we don’t recognize the possibility of ill-effects
They effectively do not exist.
Lucine Health Sciences, Inc. | Hormones Matter
Lucine Health Sciences, Inc. | Hormones Matter
We are drowning
in a sea of toxins
Lucine Health Sciences, Inc. | Hormones Matter
Environmental toxic soup“Unlike the current system in Europe, the 60,000-plus chemicals in production when the US’s TSCA took effect 39 years ago continued to be used without any safety reviews. Most are still in use today, although some have since filed toxicity data.The US allows the use of many chemicals that are banned elsewhere, and its primary chemicals law has failed to keep up with thousands of chemicals currently in use, including the approximately 2,000 new chemicals introduced each year.”
Source: https://www.theguardian.com/lifeandstyle/2015/feb/13/us-senate-toxic-chemicals-law-health-safety
Friday 13 February 2015 13.41 EST
Lucine Health Sciences, Inc. | Hormones Matter
That remain in our bodies
Certain polychlorinated biphenyls, organochlorine pesticides, PFCs, phenols, PBDEs, phthalates, polycyclic aromatic hydrocarbons, and perchlorate were detected in 99–100% of pregnant women. The median number of detected chemicals by chemical class ranged from 4 of 12 PFCs to 9 of 13 phthalates. Across chemical classes, median number ranged from 8 of 17 chemical analytes to 50 of 71 chemical analytes.
BPA and tOP were detected in 92.6% and 57.4% of the persons, respectively...Females had statistically higher BPA LSGM concentrations than males (p = 0.043). Children had higher concentrations than adolescents (p < 0.001), who in turn had higher concentrations than adults (p = 0.003).
Lucine Health Sciences, Inc. | Hormones Matter
Affecting generations to come
Lucine Health Sciences, Inc. | Hormones Matter
What would normally filter the damage
Medicines Toxins Bad diet
Nutrients Exercise
Has been compromised.
Lucine Health Sciences, Inc. | Hormones Matter
Maternal nutrient deficiency is rampant
Oxidative stress caused by free radicals has been implicated in many studies of the etiology of preeclampsia (38). Because ascorbic acid and vitamin E inhibit free radical formation, a double-blind randomized trial was conducted in 283 women who had either a previous history of pregnancy complications or an abnormal ultrasound (39). The supplement provided 1000 mg ascorbic acid and 400 IU vitamin E daily from week 16–22 of pregnancy, and resulted in a 76% reduction in preeclampsia, and a 21% reduction in indicators of endothelial activation and placental dysfunction.
Evidence from experimental animals supports the concept that in addition to primary deficiencies, secondary embryonic and fetal nutritional deficiencies can be caused by diverse factors including genetics, maternal disease, toxicant insults and physiological stressors that can trigger a maternal acute phase response. These secondary responses may be significant contributors to the occurrence of birth defects. An implication of the above is that the frequency and severity of pregnancy complications may be reduced through an improvement in the micronutrient status of the mother .
Micronutrient status in fetal and early life may alter metabolism, vasculature, and organ growth and function, leading to increased risk of cardiometabolic disorders, adiposity, altered kidney function, and, ultimately, to type 2 diabetes and cardiovascular diseases.
Lucine Health Sciences, Inc. | Hormones Matter
The food we eat
Isn’t really food
High calorie malnutrition
Lucine Health Sciences, Inc. | Hormones Matter
It’s food like
Lucine Health Sciences, Inc. | Hormones Matter
We’re told it’s real food“Everything nature can do, man can do so much better and more profitably.”
o ‘Natural’ cheese that matures in 72 hours.
o Preservatives prevent produce browning
And if we can’t, then re-defineo ‘Clean labeling’ removes the most
glaring industrial ingredients and replaces them with substitutes that sound natural and benign.
“For the salesman, this preparation was a technical triumph, a boon to caterers who would otherwise waste unsold food. There was a further benefit: NatureSeal is classed as a processing aid, not an ingredient, so there’s no need to declare it on the label, no obligation to tell consumers that their “fresh” fruit salad is weeks old.”
But it isn’t.
Lucine Health Sciences, Inc. | Hormones Matter
Industrial food productiono Highly processed food-like products
o Sugar, carbs, fats and chemicals
o Genetically culled produceo 70% reduced nutrient contento With no genetic variation ( 96%)
o Glyphosate, toxic adjuvants and more
o Chemically laden meats o Heavy antibiotics, antibiotic resistant
bacteria, growth and other hormonesHas stripped our food of critical nutrients
Lucine Health Sciences, Inc. | Hormones Matter
It’s an industrial descaling agent
oUsed to remove minerals from pipesoDoes the same in our bodies
• Blocks critical enzymes and amino acids
• Disrupts vitamin A metabolism
• Weakens the blood brain barrier
oCarcinogenic, mutagenic, teratogenic and an endocrine disruptor
• Topoisomerase inhibitor
• Glycine analog
• Mineral chelator
oWould kill all the plants if not genetically altered to withstand the toxinAnd a powerful antibiotic.
Lucine Health Sciences, Inc. | Hormones Matter
A perfect storm
Of pharmaceutical and environmental toxicants.
Lucine Health Sciences, Inc. | Hormones Matter
But, cancer is random?
And most women’s symptoms are psychosomatic – until they aren’t’.
Lucine Health Sciences, Inc. | Hormones Matter
Lucine Health Sciences, Inc. | Hormones Matter
ConsequencesThe rise of random ill-health.
Lucine Health Sciences, Inc. | Hormones Matter
Suffering from a multitude of chronic illnesses
Lucine Health Sciences, Inc. | Hormones Matter
Lucine Health Sciences, Inc. | Hormones Matter
Lucine Health Sciences, Inc. | Hormones Matter
With generational effects
Lucine Health Sciences, Inc. | Hormones Matter
Increase in childhood illnesso1-68 children develop
autism o Neurodevelopmental and behavioral
problems on the rise
o1 in 13 children food allergies
o1 in 1000 – 10,000 children with autoimmune disorder (celiac, JA, TD1)JAMA Pediatr. 2013;167(2):141-148; Psychiatry (Edgmont). Aug 2005; 2(8): 14–19; Arch Gen Psychiatry. 2012;69(12):1247-1256; BMC
Pediatrics 2013, 13:40 3; JAMA. 2014;311(17):1778-1786.
Idiopathic or random?
Lucine Health Sciences, Inc. | Hormones Matter
Something is not working• Spend more healthcare• Highly vaccinated • Taking lots of meds
• That were never tested on over half the population
• Of those, only 50% considered effective
• Embrace environmental/industrial chemistry
• Living sicker• With increasingly
complicated but ‘random’ diseases
• Dying younger
Lucine Health Sciences, Inc. | Hormones Matter
Lucine Health Sciences, Inc. | Hormones Matter
How can we reasonably assert
Which health issues are idiopathic and which are caused by us?
Lucine Health Sciences, Inc. | Hormones Matter
Except in rare casesoMost modern illness is iatrogenic – caused by us
• Our choices individually and collectively• Diet, lifestyle, pharmaceutical and environmental decisions
“I believe the collective denial of lifestyle disease is the reason cardiology is in an innovation rut. This denial is not active or overt. It is indolent and
apathetic… This is how I see modern cardiology. Our tricks can no longer overcome eating too much and moving too little. We approach health but
never get there. If you waddle, snore at night, and cannot see your toes while standing, how much will a statin or ACE inhibitor or even LCZ696 help?”
Mandrola, J., 2015. Heart Disease and Lifestyle: Why Are Doctors in Denial? Medscape. http://www.medscape.com/viewarticle/837975
A hard truth that none of us wants to admit
Lucine Health Sciences, Inc. | Hormones Matter
Now what? Who cares whether we call it idiopathic or iatrogenic, how do we fix this mess?
Lucine Health Sciences, Inc. | Hormones Matter
Easy answeroStop
• eating food-like products• looking for medical
solutions to what are lifestyle issues
oGo back to basics• What does your body
need and is it getting it?
Lucine Health Sciences, Inc. | Hormones Matter
More complicated answeroFind the root causes of illness and
fix them• Stop treating symptoms
• Learn the chemistry
oBecome an expert in your/your family’s health
• Own your health
oShare what you learn with others • Build the knowledge base
• Publish/post online if you canEntire model has to change.
Lucine Health Sciences, Inc. | Hormones Matter
What I have learned
It’s all about the mitochondria.
Feed them well and life will be good.
Lucine Health Sciences, Inc. | Hormones Matter
Mitochondriao1000-2000 per cell
oFuel source for cells • Convert food to ATP
oSit at center of cell survival• Sense and respond to all threats
oMasters at adapting to toxic environments – until they aren’t
• Seemingly endless repertoire of survival cascades• Threshold and tipping points
Lucine Health Sciences, Inc. | Hormones Matter
But that’s not all they do oMitochondria control just about everything
o Energy
o Steroidogenesis
o Inflammatory and immune activation/deactivation
o Ca2+ homeostasis (cell excitotoxicity)
o Apoptosis/necrosisDamage at your own risk.
Lucine Health Sciences, Inc. | Hormones Matter
All they ask of us is to feed them welloTo get from food to
ATP• O2 (mitochondria
need to breathe)• Lots of nutrients
• >24 vitamins and minerals
And not hurl too many poisons at them.Source: https://www.invitehealth.com/ARTICLE-nutrition-and-fibromyalgia.html
Lucine Health Sciences, Inc. | Hormones Matter
Western diet = high calorie malnutrition.
We don’t.
Nutrient deficiency alone will damage mitochondria, evoke chronic and complicated illness and can lead to
death.
Lucine Health Sciences, Inc. | Hormones Matter
All pharmaceutical, environmental, and industrial chemicals damage the
mitochondria and deplete nutrients.
But wait, there’s more…
Lucine Health Sciences, Inc. | Hormones Matter
Mitochondria are targets
Sensors of cell danger
Lucine Health Sciences, Inc. | Hormones Matter
Poor nutrition, high toxic load
Foundation from which most parents-to-be approach reproduction
With the cascade of ill-health already in
progress.
Lucine Health Sciences, Inc. | Hormones Matter
Net result“These are partial defects.
Mitochondrial dysfunction doesn’t really cause anything, what it does is
predisposes towards seemingly everything. It’s one of many risk factors
in multifactorial disease. It can predispose towards epilepsy, chronic
fatigue, and even autism, but it doesn’t do it alone. It does it in combination with other factors, which is why in a family with a single mutation going through the family, everyone in the family is affected in a different way. Because it predisposes for disease
throughout the entire system.” Dr. Richard Boles, Geneticist
Complicated disease processes that affect everything and don’t fit our neat little
diagnostic categories.
Lucine Health Sciences, Inc. | Hormones Matter
How prevalent is mitochondrial disease or dysfunction?
“Disorders of the mitochondrial respiratory chain affect at least 1 in 8000 of the population, making them among the most common genetically determined diseases.”
Patrick Chinnery, Medical School, Newcastle upon Tyne.
Prevalence is likely underestimated because functional mitochondrial damage is often overlooked and most mitochondrial deficits, especially those emerging later in life, remain undiagnosed.
Not widely recognized
1 in 500
Lucine Health Sciences, Inc. | Hormones Matter
Energy is key• Insufficient mitochondrial ATP
• Cells adapt alternative, less efficient energy pathwayso Cancer pathways or they die
• Mitochondria activate danger protocols and deactivate extraneous tasks
• Cells die, tissues die, organs die, and we die (sometimes slowly and painfully, sometimes quickly)
Lucine Health Sciences, Inc. | Hormones Matter
How important are nutrientsoCells cannot ‘breathe’ without certain
vitamins and minerals• Thiamine and magnesium
oNutrient deficiency causes cellular hypoxia • No obstruction necessary
oBrain and heart most adversely effected
Lucine Health Sciences, Inc. | Hormones Matter
During pregnancy
Lucine Health Sciences, Inc. | Hormones Matter
Direct Mitochondrial membrane
permeability changes Alter channel open times Activate death pathways
Indirect Block critical nutrient co-factors
for ATP Alters hormone activity
(endocrine disruptors) Activate/deactivate critical
transcription and repair proteins (epigenetics)
Cycle of damage
mtDNA damage
Functional deficits
mtDNA mutation
s
Altered ETCDecreased
ATPMito damage
Increased ROS
Oxidative stress
Toxic ExposuresMedications, Vaccines, Environmental
Cell death & disease
Lucine Health Sciences, Inc. | Hormones Matter
Cascade of ill health
Lucine Health Sciences, Inc. | Hormones Matter
Not just about momo mDNA passed from mom-child,
o But mitochondria rely on nuclear DNA to function (~90%)
o If Dad is unhealthy and nutrient deficient, dysfunctional mitochondria are possible in the offspring, even if mom is healthy
Dad’s health matters too!
Lucine Health Sciences, Inc. | Hormones Matter
Long before conceptionoThe lifetime of unhealthy habits affect your
mitochondria o Mitochondria have memories
oCleaning up a few months before conception is good but not good enougho Should consider health of both parents at least a
year before conception
Health has to be considered
Lucine Health Sciences, Inc. | Hormones Matter
Nutrients minimize damage
Medicines Toxins Diet
Nutrients Exercise
Nutrient deficiency maximizes damage.
Lucine Health Sciences, Inc. | Hormones Matter
All comes back to nutrients
Lucine Health Sciences, Inc. | Hormones Matter
Avoid the toxinsClean up the dietFeed the deficiencies
Lucine Health Sciences, Inc. | Hormones Matter
Idiopathy versus iatrogenesisoWhen presented with complicated case, a disease process
that doesn’t seem to fit into any one category• Remove the notion of randomness/idiopathy • Return the notion of responsibility• Figure it out (together)• Think mitochondria
oAsk • What the patient needs to be healthy• Are they getting it
oFix it
Lucine Health Sciences, Inc. | Hormones Matter
Websites
o LucineHealthSciences.com I Business
o HormonesMatter.com I online journal, medication adverse events surveys
Social Media o Facebook pages: Hormones Matter, Lucine Women Community
o Twitter: @chanatlucine, @hormonesmatter
o Email: [email protected] or [email protected]
How to find me