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CYCLOPHOSPHAMIDE (Chemotherapy drug)
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CYCLOPHOSPHAMIDE
Ferdinand F. Fatiga, RMT
CYCLOPHOSPHAMIDE
Used in the treatment of WBC cancers
(AML/ALL) and Lymphoma
Cell Cycle – Non specific
Alkylating agent Adds Alkyl group (CnH2n+1) to DNA
CYCLOPHOSPHAMIDE
Mechanism of Action
• the main effect of cyclophosphamide is due to its metabolite Phosphoramide mustard
• Phosphoramide mustard forms DNA crosslinks between (interstrand crosslinkages) and within (intrastrand crosslinkages) DNA strands at guanine N-7 position, this eventually leads to cell death
CYCLOPHOSPHAMIDE Activation
CYCLOPHOSPHAMIDE
CONCLUSION
Expression of genes that code for Cytochrome P450 (Oxidase Enzyme) and ALDH enzymes affects the sensitivity of Cancer cells to Cyclophosphamide since these enzymes affect the metabolism of the prodrug (Cyclophosphamide) to its active Phosphoramide mustard metabolite.